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CKB recombinant protein

Scan QR to view Datasheet Catalog #    MBS203740
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CKB, Recombinant Protein

 Also Known As   

CKB, 1-381aa, Human, His tag, E Coli

 Product Synonym Names    Creatine kinase B-type; B-CK; CKBB; Creatine kinase B-type; BCK
 Product Gene Name   

CKB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K
 OMIM    M16451 mRNA
 3D Structure    ModBase 3D Structure for P12277
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CKB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CKB recombinant protein

   CKB (Creatine kinase B-type) is a cytoplasmic enzyme involved in energy homeostasis. The protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. Creatine kinases provide the energy of phosphate hydrolysis necessary to drive the normal function of many cellular systems including muscle, tumor and cancer cells. Recombinant human CKB protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography technique
 Product Categories/Family for CKB recombinant protein    Metabolism
 Applications Tested/Suitable for CKB recombinant protein   

SDS-PAGE

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 SDS-Page of CKB recombinant protein    CKB recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for CKB. It may not necessarily be applicable to this product.
 NCBI GI #    21536286
 NCBI GeneID    1152
 NCBI Accession #    NP_001814 [Other Products]
 NCBI GenBank Nucleotide #    NM_001823.4 [Other Products]
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 UniProt Primary Accession #    P12277 [Other Products]
 UniProt Secondary Accession #    Q2LE07; Q6FG40; Q9UC66; A8K236; B2R5R4 [Other Products]
 UniProt Related Accession #    P12277 [Other Products]
 Molecular Weight    44.8 kDa (401aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    creatine kinase B-type
 NCBI Official Synonym Full Names    creatine kinase B
 NCBI Official Symbol    CKB [Similar Products]
 NCBI Official Synonym Symbols   
BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29
[Similar Products]
 NCBI Protein Information    creatine kinase B-type
 UniProt Protein Name    Creatine kinase B-type
 UniProt Synonym Protein Names   
Brain creatine kinase
 Protein Family    Creatine kinase
 UniProt Gene Name    CKB [Similar Products]
 UniProt Synonym Gene Names    CKBB; CPK-B [Similar Products]
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 NCBI Summary for CKB    The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CKB    Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
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Product References and Citations for CKB recombinant protein

   Chang EJ., et al. (2008) Nat Med. 14 (9):966-72. ; Debrincat MA., et al. (2007) J Biol Chem. 282 (7):4728-37.;
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 Research Articles on CKB    1. Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CKB recombinant proteinPathways associated with CKB recombinant protein
 Reference Product  PubMed Publications
 CKM recombinant protein  >16 publications with CKB and CKM
 ASB9 recombinant protein  >2 publications with CKB and ASB9
 LDHB recombinant protein  >1 publications with CKB and LDHB
 GAMT recombinant protein  >1 publications with CKB and GAMT
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Creatine Metabolism Pathway antibodies  Creatine Metabolism Pathway Diagram
 Creatine Pathway antibodies  Creatine Pathway Diagram
 Creatine Pathway antibodies  Creatine Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Urea Cycle And Metabolism Of Amino Groups Pathway antibodies  Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
Diseases associated with CKB recombinant proteinOrgans/Tissues associated with CKB recombinant protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >21 publications with CKB and Brain Diseases
 Nervous System Diseases Antibodies  >19 publications with CKB and Nervous System Diseases
 Heart Diseases Antibodies  >13 publications with CKB and Heart Diseases
 Liver Diseases Antibodies  >8 publications with CKB and Liver Diseases
 Lung Diseases Antibodies  >7 publications with CKB and Lung Diseases
 Movement Disorders Antibodies  >5 publications with CKB and Movement Disorders
 Hemorrhage Antibodies  >5 publications with CKB and Hemorrhage
 Adenocarcinoma Antibodies  >5 publications with CKB and Adenocarcinoma
 Cognition Disorders Antibodies  >4 publications with CKB and Cognition Disorders
 Breast Neoplasms Antibodies  >4 publications with CKB and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with CKB and Brain
 Blood Antibodies  >36 publications with CKB and Blood
 Heart Antibodies  >21 publications with CKB and Heart
 Muscle Antibodies  >18 publications with CKB and Muscle
 Uterus Antibodies  >13 publications with CKB and Uterus
 Liver Antibodies  >11 publications with CKB and Liver
 Lung Antibodies  >8 publications with CKB and Lung
 Nerve Antibodies  >8 publications with CKB and Nerve
 Bone Antibodies  >7 publications with CKB and Bone
 Kidney Antibodies  >4 publications with CKB and Kidney
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