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CLEC4A / CLECSF6 / DCIR recombinant protein

Scan QR to view Datasheet Catalog #    MBS2545773
SDS-PAGE
Unit / Price
0.02 mg  /  $375 +1 FREE 8GB USB
0.05 mg  /  $775 +1 FREE 8GB USB
 
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 Product Name   

CLEC4A / CLECSF6 / DCIR, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human CLEC4A / CLECSF6 / DCIR Protein (His tag)

 Product Synonym Names    HDCGC13P, CLECSF6, DCIR, DDB27, LLIR, CLEC4A
 Product Gene Name   

CLEC4A / CLECSF6 / DCIR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF006740 mRNA
 3D Structure    ModBase 3D Structure for O43405
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 Host    Human Cells
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 Purity/Purification    > 95 % as determined by SDS-PAGE
 Form/Format    Lyophilized from sterile PBS, pH 7.4, 5%trehalose, 5%mannitol, 0.01%Tween80.
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 Source    Human
 Predicted N terminal    His
 Molecular Mass    The recombinant human CLEC4A consists of 184 amino acids and has a calculated molecular mass of 22 kDa. In SDS-PAGE under reducing conditions, rhCLEC4A migrates as an approximately 28 kDa band due to glycosylation.
  Endotoxin    < 1.0 EU per ug of the protein as determined by the LAL method.
 Protein Consuntration    A DNA sequence encoding the human CLEC4A (NP_001128530.1) extracellular domain (Gln 70-Leu 237) was expressed, with a polyhistidine tag at the N-terminus
 Reconstitution    It is recommended that sterile water (80 ul) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV-Vis.
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 Preparation and Storage    Storage: Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Stability: Samples are stable for up to twelve months from date of receipt at -70C
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CLEC4A / CLECSF6 / DCIR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CLEC4A / CLECSF6 / DCIR recombinant protein

   Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily member 6 (CLECSF6), is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. The Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4 (+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection.

Description: A DNA sequence encoding the human CLEC4A (NP_001128530.1) extracellular domain (Gln 70-Leu 237) was expressed, with a polyhistidine tag at the N-terminus.
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 SDS-PAGE of CLEC4A / CLECSF6 / DCIR recombinant protein    CLEC4A / CLECSF6 / DCIR recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CLEC4A / CLECSF6 / DCIR. It may not necessarily be applicable to this product.
 NCBI GI #    205277471
 NCBI GeneID    1690
 NCBI Accession #    NP_001128530.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135058.1 [Other Products]
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 UniProt Primary Accession #    O43405 [Other Products]
 UniProt Secondary Accession #    Q96IU6; A8K9K9; D3DS84 [Other Products]
 UniProt Related Accession #    O43405 [Other Products]
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 NCBI Official Full Name    cochlin isoform b
 NCBI Official Synonym Full Names    cochlin
 NCBI Official Symbol    COCH [Similar Products]
 NCBI Official Synonym Symbols   
DFNA9; COCH5B2; COCH-5B2
[Similar Products]
 NCBI Protein Information    cochlin
 UniProt Protein Name    Cochlin
 UniProt Synonym Protein Names   
COCH-5B2
 UniProt Gene Name    COCH [Similar Products]
 UniProt Synonym Gene Names    COCH5B2 [Similar Products]
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 NCBI Summary for CLEC4A / CLECSF6 / DCIR    The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
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 UniProt Comments for CLEC4A / CLECSF6 / DCIR    COCH: Plays a role in the control of cell shape and motility in the trabecular meshwork. Defects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9). DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: extracellular matrix

Molecular Function: collagen binding; protein binding

Biological Process: regulation of cell shape

Disease: Deafness, Autosomal Dominant 9
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 Research Articles on CLEC4A / CLECSF6 / DCIR    1. This study showed that Mendelian sensorineural hearing loss exhibits vestibular dysfunction, including DFNA9, DFNA11, DFNA15 and DFNA28.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CLEC4A / CLECSF6 / DCIR recombinant proteinDiseases associated with CLEC4A / CLECSF6 / DCIR recombinant protein
 Reference Product  PubMed Publications
 TECTA recombinant protein  >8 publications with CLEC4A / CLECSF6 / DCIR and TECTA
 COL2A1 recombinant protein  >1 publications with CLEC4A / CLECSF6 / DCIR and COL2A1
 ANXA2 recombinant protein  >1 publications with CLEC4A / CLECSF6 / DCIR and ANXA2
 SLC44A2 recombinant protein  >1 publications with CLEC4A / CLECSF6 / DCIR and SLC44A2
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >118 publications with CLEC4A / CLECSF6 / DCIR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >18 publications with CLEC4A / CLECSF6 / DCIR and Cardiovascular Diseases
 Brain Diseases Antibodies  >14 publications with CLEC4A / CLECSF6 / DCIR and Brain Diseases
 Disease Models, Animal Antibodies  >10 publications with CLEC4A / CLECSF6 / DCIR and Disease Models, Animal
 Inflammation Antibodies  >9 publications with CLEC4A / CLECSF6 / DCIR and Inflammation
 Hypertension Antibodies  >6 publications with CLEC4A / CLECSF6 / DCIR and Hypertension
 Liver Diseases Antibodies  >6 publications with CLEC4A / CLECSF6 / DCIR and Liver Diseases
 Myocardial Infarction Antibodies  >5 publications with CLEC4A / CLECSF6 / DCIR and Myocardial Infarction
 Abnormalities, Multiple Antibodies  >5 publications with CLEC4A / CLECSF6 / DCIR and Abnormalities, Multiple
 Edema Antibodies  >3 publications with CLEC4A / CLECSF6 / DCIR and Edema
Organs/Tissues associated with CLEC4A / CLECSF6 / DCIR recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Ear Antibodies  >66 publications with CLEC4A / CLECSF6 / DCIR and Ear
 Blood Antibodies  >44 publications with CLEC4A / CLECSF6 / DCIR and Blood
 Brain Antibodies  >40 publications with CLEC4A / CLECSF6 / DCIR and Brain
 Eye Antibodies  >25 publications with CLEC4A / CLECSF6 / DCIR and Eye
 Nerve Antibodies  >15 publications with CLEC4A / CLECSF6 / DCIR and Nerve
 Bone Antibodies  >14 publications with CLEC4A / CLECSF6 / DCIR and Bone
 Spleen Antibodies  >8 publications with CLEC4A / CLECSF6 / DCIR and Spleen
 Liver Antibodies  >8 publications with CLEC4A / CLECSF6 / DCIR and Liver
 Lung Antibodies  >6 publications with CLEC4A / CLECSF6 / DCIR and Lung
 Skin Antibodies  >5 publications with CLEC4A / CLECSF6 / DCIR and Skin
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