NP_001091952.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CREB-regulated transcription coactivator 1 isoform 3
NCBI Official Synonym Full Names
CREB regulated transcription coactivator 1
NCBI Protein Information
CREB-regulated transcription coactivator 1
UniProt Protein Name
CREB-regulated transcription coactivator 1
UniProt Synonym Protein Names
Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1
UniProt Synonym Gene Names
UniProt Entry Name
CRTC1_HUMAN
UniProt Comments for CRTC1
TORC1: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane
Molecular Function: cAMP response element binding protein binding; protein binding
Biological Process: activation of CREB transcription factor; entrainment of circadian clock by photoperiod; positive regulation of transcription from RNA polymerase II promoter
Research Articles on CRTC1
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Products associated with CRTC1 recombinant protein
Pathways associated with CRTC1 recombinant protein
Diseases associated with CRTC1 recombinant protein
Organs/Tissues associated with CRTC1 recombinant protein
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