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CSTA recombinant protein

Scan QR to view Datasheet Catalog #    MBS203907
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSTA, Recombinant Protein

 Also Known As   

CSTA, 1-98aa, Human, His tag, E Coli

 Product Synonym Names    Cystatin-A; STF1; STFA
 Product Gene Name   

CSTA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MIPGGLSEAK PATPEIQEIV DKVKPQLEEK TNETYGKLEA VQYKTQVVAG TNYYIKVRAG DNKYMHLKVF KSLPGQNEDL VLTGYQVDKN KDDELTGF
 OMIM    X05978 mRNA
 3D Structure    ModBase 3D Structure for P01040
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Absorbance at 280nm) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CSTA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CSTA recombinant protein

   CSTA, also known as Stefin A, is thiol protease inhibitors that form complexes with papain and the cathepsins B, H and L. The protein is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. CSTA is thought to be a tumor suppressor, since an inverse correlation seems to exist between the level of CSTA and tumor progression, in several malignancies Recombinant human CSTA protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for CSTA recombinant protein    Cancer
 Applications Tested/Suitable for CSTA recombinant protein   

SDS-PAGE

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 SDS-Page of CSTA recombinant protein    CSTA recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for CSTA. It may not necessarily be applicable to this product.
 NCBI GI #    4885165
 NCBI GeneID    1475
 NCBI Accession #    NP_005204 [Other Products]
 NCBI GenBank Nucleotide #    NM_005213.3 [Other Products]
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 UniProt Primary Accession #    P01040 [Other Products]
 UniProt Secondary Accession #    Q6IB90 [Other Products]
 UniProt Related Accession #    P01040 [Other Products]
 Molecular Weight    13.1 kDa (118aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    cystatin-A
 NCBI Official Synonym Full Names    cystatin A
 NCBI Official Symbol    CSTA [Similar Products]
 NCBI Official Synonym Symbols   
AREI; PSS4; STF1; STFA
[Similar Products]
 NCBI Protein Information    cystatin-A
 UniProt Protein Name    Cystatin-A
 UniProt Synonym Protein Names   
Cystatin-AS; Stefin-A
 Protein Family    Cystatin
 UniProt Gene Name    CSTA [Similar Products]
 UniProt Synonym Gene Names    STF1; STFA [Similar Products]
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 NCBI Summary for CSTA    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CSTA    This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
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Product References and Citations for CSTA recombinant protein

   Takai T., et al. (2009) J Immunol. 183 (12):7958-65.; Sinha AA., et al. (2008) Anticancer Res. 28 (4B):2271-7.
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 Research Articles on CSTA    1. Identify myoepithelial cell stefin A as a suppressor of early tumor invasion and a candidate marker to distinguish patients who are at low risk of developing invasive breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CSTA recombinant proteinPathways associated with CSTA recombinant protein
 Reference Product  PubMed Publications
 CTSL1 recombinant protein  >18 publications with CSTA and CTSL1
 CTSH recombinant protein  >7 publications with CSTA and CTSH
 CTSB recombinant protein  >2 publications with CSTA and CTSB
 CST4 recombinant protein  >1 publications with CSTA and CST4
 CTSL2 recombinant protein  >1 publications with CSTA and CTSL2
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Formation Of The Cornified Envelope Pathway antibodies  Formation Of The Cornified Envelope Pathway Diagram
 Keratinization Pathway antibodies  Keratinization Pathway Diagram
Diseases associated with CSTA recombinant proteinOrgans/Tissues associated with CSTA recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >16 publications with CSTA and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >14 publications with CSTA and Adenocarcinoma
 Breast Neoplasms Antibodies  >10 publications with CSTA and Breast Neoplasms
 Disease Progression Antibodies  >9 publications with CSTA and Disease Progression
 Neoplasm Metastasis Antibodies  >9 publications with CSTA and Neoplasm Metastasis
 Chromosome Aberrations Antibodies  >8 publications with CSTA and Chromosome Aberrations
 Lung Neoplasms Antibodies  >7 publications with CSTA and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with CSTA and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >6 publications with CSTA and Cardiovascular Diseases
 Hyperplasia Antibodies  >5 publications with CSTA and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with CSTA and Blood
 Skin Antibodies  >31 publications with CSTA and Skin
 Liver Antibodies  >12 publications with CSTA and Liver
 Lung Antibodies  >9 publications with CSTA and Lung
 Brain Antibodies  >8 publications with CSTA and Brain
 Kidney Antibodies  >5 publications with CSTA and Kidney
 Vascular Antibodies  >5 publications with CSTA and Vascular
 Prostate Antibodies  >4 publications with CSTA and Prostate
 Bone Marrow Antibodies  >3 publications with CSTA and Bone Marrow
 Ovary Antibodies  >3 publications with CSTA and Ovary
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