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CTGF recombinant protein

Scan QR to view Datasheet Catalog #    MBS232397 CTGF recombinant protein
Unit / Price
0.02 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CTGF, Recombinant Protein

★Popular Item★
 Also Known As   

RECOMBINANT HUMAN CTGF

 Product Gene Name   

CTGF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    121009
 3D Structure    ModBase 3D Structure for P29279
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 Purity/Purification    >95% by SDS PAGE/HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Total protein concentration 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.2ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Buffer Solution    10mM Sodium Acetate
 Activity    Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 ug/ml.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of CTGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CTGF recombinant protein

   CTGF (connective tissue growth factor) is a heparin-binding pleiotropic growth factor and member of the CCN family of secreted cysteine rich regulatory proteins, which interacts with other growth factors including transforming growth factor beta (TGF-beta), vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs). CTGF promotes the adhesion of epithelial cells and fibroblasts, stimulates integrin expression, and promotes endothelial cell survival, migration and adhesion, implicating CTGF in angiogenesis. CTGF is involved in chondrogenesis and potentially skeletogenesis, induces extracellular matrix formation and has also been implicated in wound healing.
 Applications Tested/Suitable for CTGF recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for CTGF recombinant protein    ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well;
Functional Assays: Minimum Dilution: 1.0; Maximum Dilution: 2.0ug/ml;
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for CTGF. It may not necessarily be applicable to this product.
 NCBI GI #    4503123
 NCBI GeneID    1490
 NCBI Accession #    NP_001892.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001901.2 [Other Products]
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 UniProt Primary Accession #    P29279 [Other Products]
 UniProt Secondary Accession #    Q6LCY0; Q96A79; Q96QX2; Q9UDL6; E1P578 [Other Products]
 UniProt Related Accession #    P29279 [Other Products]
 Molecular Weight    11.2kD (98 amino acid residues)
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 NCBI Official Full Name    connective tissue growth factor
 NCBI Official Synonym Full Names    connective tissue growth factor
 NCBI Official Symbol    CTGF [Similar Products]
 NCBI Official Synonym Symbols   
CCN2; NOV2; HCS24; IGFBP8
[Similar Products]
 NCBI Protein Information    connective tissue growth factor; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8
 UniProt Protein Name    Connective tissue growth factor
 UniProt Synonym Protein Names   
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
 Protein Family    Connective tissue growth factor
 UniProt Gene Name    CTGF [Similar Products]
 UniProt Synonym Gene Names    CCN2; HCS24; IGFBP8; IBP-8; IGF-binding protein 8; IGFBP-8 [Similar Products]
 UniProt Entry Name    CTGF_HUMAN
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 NCBI Summary for CTGF    The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CTGF    CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; cis-Golgi network; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; extracellular region; cell cortex; cytosol

Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; protein binding; growth factor activity; fibronectin binding

Biological Process: response to peptide hormone stimulus; epidermis development; response to anoxia; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of caspase activity; positive regulation of JNK cascade; cellular lipid metabolic process; response to estradiol stimulus; cell-cell signaling; positive regulation of stress fiber formation; positive regulation of cell proliferation; tissue homeostasis; response to glucose stimulus; response to wounding; regulation of cell growth; angiogenesis; cell differentiation; cell adhesion; cartilage condensation; positive regulation of cell activation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; cell migration; ossification; fibroblast growth factor receptor signaling pathway; organ senescence; response to mineralocorticoid stimulus; response to amino acid stimulus; gene expression; regulation of chondrocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of cell differentiation; lung development
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 Research Articles on CTGF    1. the SSc epidermis provides an important source of pro-fibrotic CCN2 and proinflammatory S100A9 in SSc skin, and therefore contributes to the fibrosis and inflammation seen in the disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTGF recombinant proteinPathways associated with CTGF recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >666 publications with CTGF and TGFB1
 SMAD7 recombinant protein  >57 publications with CTGF and SMAD7
 VEGFA recombinant protein  >24 publications with CTGF and VEGFA
 BMP7 recombinant protein  >18 publications with CTGF and BMP7
 BMP4 recombinant protein  >14 publications with CTGF and BMP4
 FN1 recombinant protein  >14 publications with CTGF and FN1
 TGFBR2 recombinant protein  >13 publications with CTGF and TGFBR2
 WWTR1 recombinant protein  >11 publications with CTGF and WWTR1
 TGFBI recombinant protein  >4 publications with CTGF and TGFBI
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 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
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 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
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 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with CTGF recombinant proteinOrgans/Tissues associated with CTGF recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1242 publications with CTGF and Fibrosis
 Disease Models, Animal Antibodies  >393 publications with CTGF and Disease Models, Animal
 Kidney Diseases Antibodies  >354 publications with CTGF and Kidney Diseases
 Cardiovascular Diseases Antibodies  >293 publications with CTGF and Cardiovascular Diseases
 Inflammation Antibodies  >286 publications with CTGF and Inflammation
 Lung Diseases Antibodies  >189 publications with CTGF and Lung Diseases
 Heart Diseases Antibodies  >180 publications with CTGF and Heart Diseases
 Liver Diseases Antibodies  >177 publications with CTGF and Liver Diseases
 Hypertension Antibodies  >159 publications with CTGF and Hypertension
 Carcinoma Antibodies  >154 publications with CTGF and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >2597 publications with CTGF and Connective Tissue
 Muscle Antibodies  >613 publications with CTGF and Muscle
 Kidney Antibodies  >597 publications with CTGF and Kidney
 Blood Antibodies  >494 publications with CTGF and Blood
 Vascular Antibodies  >453 publications with CTGF and Vascular
 Lung Antibodies  >294 publications with CTGF and Lung
 Bone Antibodies  >294 publications with CTGF and Bone
 Liver Antibodies  >287 publications with CTGF and Liver
 Heart Antibodies  >277 publications with CTGF and Heart
 Skin Antibodies  >222 publications with CTGF and Skin
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