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CX3CL1 recombinant protein :: CX3CL1/Fractalkine Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203381
SDS-Page
Unit / Price
0.1 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $1,335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CX3CL1/Fractalkine, Recombinant Protein

 Also Known As   

CX3CL1/Fractalkine, 25- 100aa, Human, His tag, E Coli

 Product Synonym Names    Chemokine (C-X3-C motif) ligand 1; ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1; CX3CL1; Chemokine (C-X3-C motif) ligand 1; small inducible cytokine subfamily D (Cys-X3-Cys) member 1 (fractalkine; neurotactin); fractalkine; neurotactin
 Product Gene Name   

CX3CL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MQHHGVTKCN ITCSKMTSKI PVALLIHYQQ NQASCGKRAI ILETRQHRLF CADPKEQWVK DAMQHLDRQA AALTRNG
 OMIM    U91835 mRNA
 3D Structure    ModBase 3D Structure for P78423
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In phosphate buffered saline (pH 7.4), 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CX3CL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CX3CL1 recombinant protein

   CX3CL1, also known as fractalkine. CX3CL1 has a unique CX3C cysteine motif near the amino terminus and is the first member of a fourth branch of the chemokine superfamily. unlike other known chemokines, CX3CL1 is a type 1 membrane protein containing a chemokine domain tethered on a long mucin like stalk. It is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Also, CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Recombinant human CX3CL1, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for CX3CL1 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for CX3CL1 recombinant protein   

SDS-PAGE

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 SDS-Page of CX3CL1 recombinant protein    CX3CL1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for CX3CL1. It may not necessarily be applicable to this product.
 NCBI GI #    4506857
 NCBI GeneID    6376
 NCBI Accession #    NP_002987 [Other Products]
 NCBI GenBank Nucleotide #    NM_002996.5 [Other Products]
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 UniProt Primary Accession #    P78423 [Other Products]
 UniProt Secondary Accession #    O00672 [Other Products]
 UniProt Related Accession #    P78423 [Other Products]
 Molecular Weight    10.9 kDa (97aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    fractalkine isoform 1
 NCBI Official Synonym Full Names    C-X3-C motif chemokine ligand 1
 NCBI Official Symbol    CX3CL1 [Similar Products]
 NCBI Official Synonym Symbols   
NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
[Similar Products]
 NCBI Protein Information    fractalkine
 UniProt Protein Name    Fractalkine
 UniProt Synonym Protein Names   
C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1
 Protein Family    Fractalkine
 UniProt Gene Name    CX3CL1 [Similar Products]
 UniProt Synonym Gene Names    FKN; NTT; SCYD1 [Similar Products]
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 NCBI Summary for CX3CL1    This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]
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 UniProt Comments for CX3CL1    Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).
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Product References and Citations for CX3CL1 recombinant protein

   Bazan JF., et al. (1997) Nature. 385 (6617):640-4. ; Papadopoulos EJ., et al. (1999) Eur J Immunol. 29 (8):2551-9. ;
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 Research Articles on CX3CL1    1. FKN concentrations are attenuated in girls with anorexia nervosa compared with healthy adolescents and are positively related to nutritional status.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CX3CL1 recombinant proteinPathways associated with CX3CL1 recombinant protein
 Reference Product  PubMed Publications
 CX3CR1 recombinant protein  >649 publications with CX3CL1 and CX3CR1
 CCR2 recombinant protein  >78 publications with CX3CL1 and CCR2
 CXCR4 recombinant protein  >48 publications with CX3CL1 and CXCR4
 CCR5 recombinant protein  >42 publications with CX3CL1 and CCR5
 CXCR3 recombinant protein  >33 publications with CX3CL1 and CXCR3
 CCR1 recombinant protein  >23 publications with CX3CL1 and CCR1
 CXCR2 recombinant protein  >16 publications with CX3CL1 and CXCR2
 CCR3 recombinant protein  >14 publications with CX3CL1 and CCR3
 CCR7 recombinant protein  >13 publications with CX3CL1 and CCR7
 TP53 recombinant protein  >1 publications with CX3CL1 and TP53
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with CX3CL1 recombinant proteinOrgans/Tissues associated with CX3CL1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >468 publications with CX3CL1 and Inflammation
 Necrosis Antibodies  >218 publications with CX3CL1 and Necrosis
 Disease Models, Animal Antibodies  >188 publications with CX3CL1 and Disease Models, Animal
 Atherosclerosis Antibodies  >121 publications with CX3CL1 and Atherosclerosis
 Lung Diseases Antibodies  >87 publications with CX3CL1 and Lung Diseases
 Pain Antibodies  >87 publications with CX3CL1 and Pain
 Heart Diseases Antibodies  >73 publications with CX3CL1 and Heart Diseases
 Kidney Diseases Antibodies  >69 publications with CX3CL1 and Kidney Diseases
 Myocardial Ischemia Antibodies  >61 publications with CX3CL1 and Myocardial Ischemia
 Liver Diseases Antibodies  >60 publications with CX3CL1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >254 publications with CX3CL1 and Brain
 Muscle Antibodies  >127 publications with CX3CL1 and Muscle
 Lung Antibodies  >110 publications with CX3CL1 and Lung
 Kidney Antibodies  >105 publications with CX3CL1 and Kidney
 Heart Antibodies  >91 publications with CX3CL1 and Heart
 Liver Antibodies  >83 publications with CX3CL1 and Liver
 Nerve Antibodies  >65 publications with CX3CL1 and Nerve
 Skin Antibodies  >51 publications with CX3CL1 and Skin
 Intestine Antibodies  >43 publications with CX3CL1 and Intestine
 Eye Antibodies  >39 publications with CX3CL1 and Eye
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