Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow CYR61  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • JAG1 Antibody
 • MAP2 Antibody
 • 60S acidic ribosomal protein P2 (RPLP2) Recombinant Protein
 • Osteoprotegerin (OPG) ELISA Kit
 • Glutathione S-Transferase M1 (mGSTM1) Recombinant Protein
 • MIP-5 ELISA Kit
 • Cdc42 Antibody
 • 1-acyl-sn-glycerol-3-phosph ate acyltransferase alpha (AGPAT1... ELISA Kit
 • UbcH9 (UBE2E3) Antibody
 • CDKN1A Antibody
 • Steroid 21-hydroxylase (CYP21A2) Recombinant Protein
 • DES Antibody
 • OVALBUMIN Antibody
 • 60S acidic ribosomal protein P0 (RPLP0) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

CYR61 recombinant protein

Scan QR to view Datasheet Catalog #    MBS1123771
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $770 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $885 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,015 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,025 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,130 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,185 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,260 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,290 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,605 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,850 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,915 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,040 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,460 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYR61, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Protein CYR61

 Product Synonym Names    CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1
 Product Gene Name   

CYR61 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    25-381aa; Full Length
 Sequence    TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD
 OMIM    602369
 3D Structure    ModBase 3D Structure for O00622
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Homo sapiens (Human)
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CYR61 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for CYR61 recombinant protein

   Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
 Product Categories/Family for CYR61 recombinant protein    Stem Cells
Section Bar
 SDS-Page of CYR61 recombinant protein    CYR61 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.
 NCBI GI #    31542331
 NCBI GeneID    3491
 NCBI Accession #    NP_001545.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001554.4 [Other Products]
Section Bar
 UniProt Primary Accession #    O00622 [Other Products]
 UniProt Secondary Accession #    O14934; O43775; Q9BZL7 [Other Products]
 UniProt Related Accession #    O00622 [Other Products]
 Molecular Weight    55.41kD
Table BarTOPTable Bar
 NCBI Official Full Name    protein CYR61
 NCBI Official Synonym Full Names    cysteine rich angiogenic inducer 61
 NCBI Official Symbol    CYR61 [Similar Products]
 NCBI Official Synonym Symbols   
CCN1; GIG1; IGFBP10
[Similar Products]
 NCBI Protein Information    protein CYR61
 UniProt Protein Name    Protein CYR61
 UniProt Synonym Protein Names   
CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1
 Protein Family    Protein
 UniProt Gene Name    CYR61 [Similar Products]
 UniProt Synonym Gene Names    CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10 [Similar Products]
 UniProt Entry Name    CYR61_HUMAN
Section Bar
 NCBI Summary for CYR61    The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Section Bar
 UniProt Comments for CYR61    CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: extracellular matrix binding; heparin binding; insulin-like growth factor binding; integrin binding

Biological Process: anatomical structure morphogenesis; cell adhesion; cell proliferation; cell-cell signaling; chemotaxis; extracellular matrix organization and biogenesis; intussusceptive angiogenesis; negative regulation of apoptosis; osteoblast differentiation; positive regulation of BMP signaling pathway; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; signal transduction
Table BarTOPTable Bar
 

Product References and Citations for CYR61 recombinant protein

   "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts." Chen C.-C., Mo F.-E., Lau L.F. J. Biol. Chem. 276:47329-47337(2001)
Section Bar
 Research Articles on CYR61    1. Overexpression of Cyr61 may induce epithelial-mesenchymal transition and therefore leads to laryngeal squamous- cell carcinoma invasion and metastasis and poor prognosis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with CYR61 recombinant proteinPathways associated with CYR61 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >93 publications with CYR61 and JUN
 FOS recombinant protein  >20 publications with CYR61 and FOS
 CTNNB1 recombinant protein  >14 publications with CYR61 and CTNNB1
 RHOA recombinant protein  >10 publications with CYR61 and RHOA
 SRF recombinant protein  >6 publications with CYR61 and SRF
 MKL1 recombinant protein  >6 publications with CYR61 and MKL1
 ITGAV recombinant protein  >1 publications with CYR61 and ITGAV
 Products by Pathway  Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 RhoA Signaling Pathway antibodies  RhoA Signaling Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with CYR61 recombinant proteinOrgans/Tissues associated with CYR61 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >63 publications with CYR61 and Inflammation
 Disease Models, Animal Antibodies  >49 publications with CYR61 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >49 publications with CYR61 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >45 publications with CYR61 and Breast Neoplasms
 Fibrosis Antibodies  >40 publications with CYR61 and Fibrosis
 Nervous System Diseases Antibodies  >31 publications with CYR61 and Nervous System Diseases
 Necrosis Antibodies  >26 publications with CYR61 and Necrosis
 Brain Diseases Antibodies  >23 publications with CYR61 and Brain Diseases
 Lung Neoplasms Antibodies  >23 publications with CYR61 and Lung Neoplasms
 Hyperplasia Antibodies  >21 publications with CYR61 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >189 publications with CYR61 and Connective Tissue
 Vascular Antibodies  >139 publications with CYR61 and Vascular
 Bone Antibodies  >86 publications with CYR61 and Bone
 Muscle Antibodies  >82 publications with CYR61 and Muscle
 Embryonic Tissue Antibodies  >57 publications with CYR61 and Embryonic Tissue
 Lung Antibodies  >52 publications with CYR61 and Lung
 Brain Antibodies  >39 publications with CYR61 and Brain
 Prostate Antibodies  >34 publications with CYR61 and Prostate
 Skin Antibodies  >33 publications with CYR61 and Skin
 Liver Antibodies  >31 publications with CYR61 and Liver
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions