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CYR61 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539410 CYR61 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYR61, Recombinant Protein

★Popular Item★
 Also Known As   

CYR61 protein

 Product Synonym Names    CYR61; CYR6-1 protein; CYR-61 protein; CYR 61; CYR 61 protein; CYR-61; CCN1 protein; GIGI protein protein
 Product Gene Name   

CYR61 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6FI18
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Supplied as a lyophilized powder.
 Concentration    20ug per vial; lyohpilized (lot specific)
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 Protein Type    Recombinant
 Biological Significance    CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
 Bioactivity    Determined by the dose-dependent stimulation of the proliferation of Mouse 3T3 cells. The expected ED50 for this effect is 2.0-3.0 ug/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CYR61 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CYR61 recombinant protein

   Purified recombinant Human CYR61 protein
 Product Categories/Family for CYR61 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for CYR61 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.
 NCBI GI #    49168524
 NCBI GeneID    3491
 NCBI Accession #    CAG38757.1 [Other Products]
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 UniProt Primary Accession #    Q6FI18 [Other Products]
 UniProt Related Accession #    O00622 [Other Products]
 Molecular Weight    42,027 Da
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 NCBI Official Full Name    CYR61
 NCBI Official Synonym Full Names    cysteine-rich, angiogenic inducer, 61
 NCBI Official Symbol    CYR61 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein CYR61
 UniProt Protein Name    CYR61 protein
 UniProt Synonym Protein Names   
CYR61 protein
 Protein Family    Protein
 UniProt Gene Name    CYR61 [Similar Products]
 UniProt Entry Name    Q6FI18_HUMAN
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 NCBI Summary for CYR61    The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
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 UniProt Comments for CYR61    CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; extracellular matrix binding

Biological Process: extracellular matrix organization and biogenesis; anatomical structure morphogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; cell proliferation; positive regulation of osteoblast differentiation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of BMP signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on CYR61    1. Cyr61 was higher in RA synovial fluid than in osteoarthritis synovial fluid. Cyr61 induced proIL-1beta production in fibroblast-like synoviocytes via the AKT-dependent NF-kappaB signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CYR61 recombinant proteinPathways associated with CYR61 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >92 publications with CYR61 and JUN
 FOS recombinant protein  >19 publications with CYR61 and FOS
 CTNNB1 recombinant protein  >14 publications with CYR61 and CTNNB1
 RHOA recombinant protein  >10 publications with CYR61 and RHOA
 SRF recombinant protein  >5 publications with CYR61 and SRF
 MKL1 recombinant protein  >5 publications with CYR61 and MKL1
 ITGAV recombinant protein  >1 publications with CYR61 and ITGAV
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 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 RhoA Signaling Pathway antibodies  RhoA Signaling Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with CYR61 recombinant proteinOrgans/Tissues associated with CYR61 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >88 publications with CYR61 and Carcinoma
 Inflammation Antibodies  >56 publications with CYR61 and Inflammation
 Disease Models, Animal Antibodies  >47 publications with CYR61 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >44 publications with CYR61 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >42 publications with CYR61 and Breast Neoplasms
 Fibrosis Antibodies  >39 publications with CYR61 and Fibrosis
 Nervous System Diseases Antibodies  >31 publications with CYR61 and Nervous System Diseases
 Necrosis Antibodies  >26 publications with CYR61 and Necrosis
 Brain Diseases Antibodies  >23 publications with CYR61 and Brain Diseases
 Neoplasms, Experimental Antibodies  >23 publications with CYR61 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >183 publications with CYR61 and Connective Tissue
 Vascular Antibodies  >130 publications with CYR61 and Vascular
 Bone Antibodies  >82 publications with CYR61 and Bone
 Muscle Antibodies  >77 publications with CYR61 and Muscle
 Embryonic Tissue Antibodies  >55 publications with CYR61 and Embryonic Tissue
 Lung Antibodies  >51 publications with CYR61 and Lung
 Brain Antibodies  >39 publications with CYR61 and Brain
 Prostate Antibodies  >33 publications with CYR61 and Prostate
 Skin Antibodies  >32 publications with CYR61 and Skin
 Liver Antibodies  >28 publications with CYR61 and Liver
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