NP_031690.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,796 Da
NCBI Official Full Name
cadherin-2
NCBI Official Synonym Full Names
cadherin 2
NCBI Protein Information
cadherin-2; neural cadherin
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
Neural cadherin; N-cadherin; CD_antigen: CD325
UniProt Synonym Gene Names
UniProt Entry Name
CADH2_MOUSE
UniProt Comments for Cdh2
CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Cellular Component: protein complex; focal adhesion; basolateral plasma membrane; T-tubule; integral to membrane; intercellular junction; fascia adherens; catenin complex; adherens junction; cell-cell adherens junction; membrane; lamellipodium; apical plasma membrane; plasma membrane; synapse
Molecular Function: protein binding; enzyme binding; metal ion binding; gamma-catenin binding; beta-catenin binding; protein complex binding; calcium ion binding; nitric-oxide synthase binding; protein phosphatase binding; protein kinase binding; alpha-catenin binding
Biological Process: cell migration; regulation of myelination; protein heterooligomerization; regulation of signal transduction; regulation of axonogenesis; heterophilic cell adhesion; cell-cell adhesion; regulation of protein localization; glial cell differentiation; synaptogenesis; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; regulation of Rho protein signal transduction; striated muscle cell differentiation; blood vessel morphogenesis; cell adhesion; homophilic cell adhesion
Research Articles on Cdh2
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Products associated with Cdh2 recombinant protein
Pathways associated with Cdh2 recombinant protein
Diseases associated with Cdh2 recombinant protein
Organs/Tissues associated with Cdh2 recombinant protein
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