NP_033998.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,903 Da
NCBI Official Full Name
cadherin-5 preproprotein
NCBI Official Synonym Full Names
cadherin 5
NCBI Official Synonym Symbols
7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA408225 [Similar Products]
NCBI Protein Information
cadherin-5
UniProt Protein Name
Cadherin-5
UniProt Synonym Protein Names
Vascular endothelial cadherin; VE-cadherin; CD_antigen: CD144
UniProt Synonym Gene Names
UniProt Entry Name
CADH5_MOUSE
NCBI Summary for Cdh5
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
UniProt Comments for Cdh5
CDH5: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Endothelial tissues and brain.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: adherens junction; cell junction; cell surface; external side of plasma membrane; intercellular junction; tight junction
Molecular Function: beta-catenin binding; protein binding; protein phosphatase binding; receptor binding
Biological Process: blood vessel maturation; cell-cell adhesion; intercellular junction assembly; negative regulation of cell proliferation; transforming growth factor beta receptor signaling pathway
Research Articles on Cdh5
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Products associated with Cdh5 recombinant protein
Pathways associated with Cdh5 recombinant protein
Diseases associated with Cdh5 recombinant protein
Organs/Tissues associated with Cdh5 recombinant protein
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