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Celsr1 recombinant protein :: Cadherin EGF LAG seven-pass G-type receptor 1 (Celsr1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1029308 Celsr1 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cadherin EGF LAG seven-pass G-type receptor 1 (Celsr1), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1 (Celsr1), partial

 Product Synonym Names    Recombinant Cadherin EGF LAG seven-pass G-type receptor 1 (Celsr1), partial; Cadherin EGF LAG seven-pass G-type receptor 1
 Product Gene Name   

Celsr1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Celsr1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000081.6 (85898758..86033777, complement). Location: 15 E2; 15 40.42 cM
 3D Structure    ModBase 3D Structure for O35161
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Celsr1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Celsr1. It may not necessarily be applicable to this product.
 NCBI GI #    115648153
 NCBI GeneID    12614
 NCBI Accession #    NP_034016.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009886.2 [Other Products]
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 UniProt Primary Accession #    O35161 [Other Products]
 UniProt Secondary Accession #    E9QK27 [Other Products]
 UniProt Related Accession #    O35161 [Other Products]
 Molecular Weight    330,471 Da [Similar Products]
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 NCBI Official Full Name    cadherin EGF LAG seven-pass G-type receptor 1
 NCBI Official Synonym Full Names    cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
 NCBI Official Symbol    Celsr1 [Similar Products]
 NCBI Official Synonym Symbols   
Scy; Crsh; crash
[Similar Products]
 NCBI Protein Information    cadherin EGF LAG seven-pass G-type receptor 1; seven-pass transmembrane receptor
 UniProt Protein Name    Cadherin EGF LAG seven-pass G-type receptor 1
 Protein Family    Cadherin EGF LAG seven-pass G-type receptor
 UniProt Gene Name    Celsr1 [Similar Products]
 UniProt Entry Name    CELR1_MOUSE
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 UniProt Comments for Celsr1    CELSR1: Receptor that may have an important role in cell/cell signaling during nervous system formation. Defects in CELSR1 are a cause of neural tube defects (NTD). NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: nucleoplasm; membrane; integral to plasma membrane; plasma membrane; integral to membrane; intracellular

Molecular Function: protein dimerization activity; G-protein coupled receptor activity; protein binding; signal transducer activity; transmembrane receptor activity; calcium ion binding

Biological Process: inner ear morphogenesis; central nervous system development; wound healing; multicellular organismal development; regulation of neurotransmitter secretion; neuron migration; locomotory behavior; gastrulation with mouth forming second; signal transduction; Rho protein signal transduction; establishment of polarity of embryonic epithelium; anterior/posterior pattern formation; G-protein coupled receptor protein signaling pathway; apical protein localization; cell surface receptor linked signal transduction; cell-cell signaling; hair follicle development; regulation of actin cytoskeleton organization and biogenesis; establishment of body hair orientation; neural tube closure; establishment of planar polarity; homophilic cell adhesion; cell adhesion
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 Research Articles on Celsr1    1. Data describe a novel distribution of Celsr1 protein to the basal surface of neuroepithelial cells within both the early neural tube and a less well-defined group of ventricular zone cells at the midline of the developing spinal cord.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Celsr1 recombinant proteinDiseases associated with Celsr1 recombinant protein
 Products by Pathway  Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >12 publications with Celsr1 and Neural Tube Defects
 Nervous System Diseases Antibodies  >8 publications with Celsr1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >7 publications with Celsr1 and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >3 publications with Celsr1 and Cardiovascular Diseases
 Carcinoma Antibodies  >3 publications with Celsr1 and Carcinoma
 Brain Diseases Antibodies  >2 publications with Celsr1 and Brain Diseases
 Adenocarcinoma Antibodies  >1 publications with Celsr1 and Adenocarcinoma
 Fibrosis Antibodies  >1 publications with Celsr1 and Fibrosis
 Lung Neoplasms Antibodies  >1 publications with Celsr1 and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with Celsr1 and Liver Diseases
Organs/Tissues associated with Celsr1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with Celsr1 and Brain
 Embryonic Tissue Antibodies  >13 publications with Celsr1 and Embryonic Tissue
 Skin Antibodies  >6 publications with Celsr1 and Skin
 Kidney Antibodies  >4 publications with Celsr1 and Kidney
 Eye Antibodies  >4 publications with Celsr1 and Eye
 Nasopharynx Antibodies  >1 publications with Celsr1 and Nasopharynx
 Heart Antibodies  >1 publications with Celsr1 and Heart
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