NP_001075694.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,829 Da
NCBI Official Full Name
calcium-activated potassium channel subunit beta-1
NCBI Official Synonym Symbols
NCBI Protein Information
calcium-activated potassium channel subunit beta-1
UniProt Protein Name
Calcium-activated potassium channel subunit beta-1
UniProt Synonym Protein Names
BK channel subunit beta-1; BKbeta; BKbeta1; Calcium-activated potassium channel, subfamily M subunit beta-1; Calcium-activated potassium channel subunit beta; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta
UniProt Synonym Gene Names
BKbeta; BKbeta1; Calcium-activated potassium channel subunit beta; Slo-beta [Similar Products]
UniProt Comments for KCNMB1
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate ().
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Diseases associated with KCNMB1 recombinant protein
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