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Camk4 recombinant protein :: Calcium/calmodulin-dependent protein kinase type IV Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717890
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $980 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,105 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,320 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,355 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,405 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,495 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,015 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,045 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,275 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,650 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calcium/calmodulin-dependent protein kinase type IV (Camk4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Calcium/calmodulin-dependent protein kinase type IV

 Product Synonym Names    CaM kinase-GR; Calspermin
 Product Gene Name   

Camk4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-474aa; Full Length
 Sequence    MLKVTVPSCP SSPCSSVTSS TENLVPDYWI DGSKRDPLSD FFEVESELGR GATSIVYRCK QKGTQKPYAL KVLKKTVDKK IVRTEIGVLL RLSHPNIIKL KEIFETPTEI SLVLELVTGG ELFDRIVEKG YYSERDAADA VKQILEAVAY LHENGIVHRD LKPENLLYAT PAPDAPLKIA DFGLSKIVEH QVLMKTVCGT PGYCAPEILR GCAYGPEVDM WSVGIITYIL LCGFEPFYDE RGDQFMFRRI LNCEYYFISP WWDEVSLNAK DLVKKLIVLD PKKRLTTFQA LQHPWVTGKA ANFVHMDTAQ KKLQEFNARR KLKAAVKAVV ASSRLGSASS SHTNIQESNK ASSEAQPAQD GKDKTDPLEN KMQAGDHEAA KAAADETMKL QSEEVEEEEG VKEEEEEEEE EEETSRMVPQ EPEDRLETDD QEMKRNSEET LKSVEEEMDP KAEEEAAAVG LGVPPQQDAI LPEY
 3D Structure    ModBase 3D Structure for P13234
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Camk4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Camk4 recombinant protein

   Isoform 1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and mory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 mory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of tporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to mory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. Isoform 2: Heat-stable, acidic, calmodulin-binding protein.
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 SDS-PAGE of Camk4 recombinant protein    Camk4 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Camk4. It may not necessarily be applicable to this product.
 NCBI GI #    77404384
 NCBI GeneID    25050
 NCBI Accession #    NP_036859.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012727.3 [Other Products]
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 UniProt Primary Accession #    P13234 [Other Products]
 UniProt Secondary Accession #    Q63892; A1A5L5 [Other Products]
 UniProt Related Accession #    P13234 [Other Products]
 Molecular Weight    57.2kD
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 NCBI Official Full Name    calcium/calmodulin-dependent protein kinase type IV
 NCBI Official Synonym Full Names    calcium/calmodulin-dependent protein kinase IV
 NCBI Official Symbol    Camk4 [Similar Products]
 NCBI Official Synonym Symbols   
Ccdpk; RATCCDPK
[Similar Products]
 NCBI Protein Information    calcium/calmodulin-dependent protein kinase type IV
 UniProt Protein Name    Calcium/calmodulin-dependent protein kinase type IV
 UniProt Synonym Protein Names   
CaM kinase-GR; Calspermin
 Protein Family    Calcium/calmodulin-dependent protein kinase
 UniProt Gene Name    Camk4 [Similar Products]
 UniProt Synonym Gene Names    CaMK IV [Similar Products]
 UniProt Entry Name    KCC4_RAT
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 NCBI Summary for Camk4    protein kinase that phosphorylates synapsin I; involved in neuronal calcium signaling; alternative transcript produces calspermin protein [RGD, Feb 2006]
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 UniProt Comments for Camk4    CAMK4: a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described.

Protein type: Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; CAMK group; CAMK1 family

Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus

Molecular Function: ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity

Biological Process: adaptive immune response; inflammatory response; long-term memory; myeloid dendritic cell cytokine production; myeloid dendritic cell differentiation; nerve-nerve synaptic transmission; nucleocytoplasmic transport; peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; signal transduction
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Product References and Citations for Camk4 recombinant protein

   Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin a gene within a gene.Ohmstede C.-A., Bland M.M., Merrill B.M., Sahyoun N.Proc. Natl. Acad. Sci. U.S.A. 88:5784-5788(1991) A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene.Means A.R., Cruzalegui F., Lemagueresse B., Needleman D.S., Slaughter G.R., Ono T.Mol. Cell. Biol. 11:3960-3971(1991) Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells.Sakagami H., Kondo H.Brain Res. Mol. Brain Res. 19:215-218(1993) Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.Sun Z., Means R.L., Le;Magueresse B., Means A.R.J. Biol. Chem. 270:29507-29514(1995) Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase.Ohmstede C.-A., Jenson K.F., Sahyoun N.J. Biol. Chem. 264:5866-5875(1989) Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein.Ono T., Slaughter G.R., Cook R.G., Means A.R.J. Biol. Chem. 264:2081-2087(1989) CREB a Ca(2+) -regulated transcription factor phosphorylated by calmodulin-dependent kinases.Sheng M., Thompson M.A., Greenberg M.E.Science 252:1427-1430(1991) Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.Tokumitsu H., Brickey D.A., Glod J., Hidaka H., Sikela J., Soderling T.R.J. Biol. Chem. 269:28640-28647(1994) Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.Matthews R.P., Guthrie C.R., Wailes L.M., Zhao X., Means A.R., McKnight G.S.Mol. Cell. Biol. 14:6107-6116(1994) Full activation of brain calmodulin-dependent protein kinase IV requires phosphorylation of the amino-terminal serine-rich region by calmodulin-dependent protein kinase IV kinase.Okuno S., Kitani T., Fujisawa H.J. Biochem. 117:686-690(1995) Phosphorylation and activation of Ca(2+) -calmodulin-dependent protein kinase IV by Ca(2+) -calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.Selbert M.A., Anderson K.A., Huang Q.H., Goldstein E.G., Means A.R., Edelman A.M.J. Biol. Chem. 270:17616-17621(1995) Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV.Sun P., Lou L., Maurer R.A.J. Biol. Chem. 271:3066-3073(1996) Inactivation of calmodulin-dependent protein kinase IV by autophosphorylation of serine 332 within the putative calmodulin-binding domain.Watanabe S., Okuno S., Kitani T., Fujisawa H.J. Biol. Chem. 271:6903-6910(1996) Multiple Ca(2+) -calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+) -calmodulin, and partial amino acid sequence.Edelman A.M., Mitchelhill K.I., Selbert M.A., Anderson K.A., Hook S.S., Stapleton D., Goldstein E.G., Means A.R., Kemp B.E.J. Biol. Chem. 271:10806-10810(1996) Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.Anderson K.A., Means R.L., Huang Q.-H., Kemp B.E., Goldstein E.G., Selbert M.A., Edelman A.M., Fremeau R.T., Means A.R.J. Biol. Chem. 273:31880-31889(1998) A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.Westphal R.S., Anderson K.A., Means A.R., Wadzinski B.E.Science 280:1258-1261(1998) Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain.Tokumitsu H., Takahashi N., Eto K., Yano S., Soderling T.R., Muramatsu M.-A.J. Biol. Chem. 274:15803-15810(1999) Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus.Lemrow S.M., Anderson K.A., Joseph J.D., Ribar T.J., Noeldner P.K., Means A.R.J. Biol. Chem. 279:11664-11671(2004)
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 Research Articles on Camk4    1. Camk4 expression in the cortical subplate was prolonged in developmentally hypothyroid pups, whereas heavy Camk4 expression in layer VIb remains at P60. Abnormal expression of Camk4 might cause altered cortical connectivity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Camk4 recombinant proteinPathways associated with Camk4 recombinant protein
 Reference Product  PubMed Publications
 Camkk2 recombinant protein  >6 publications with Camk4 and Camkk2
 Creb1 recombinant protein  >6 publications with Camk4 and Creb1
 Crem recombinant protein  >4 publications with Camk4 and Crem
 Atf2 recombinant protein  >2 publications with Camk4 and Atf2
 Camkk1 recombinant protein  >2 publications with Camk4 and Camkk1
 Mef2d recombinant protein  >1 publications with Camk4 and Mef2d
 Calm1 recombinant protein  >1 publications with Camk4 and Calm1
 Products by Pathway  Pathway Diagram
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Diseases associated with Camk4 recombinant proteinOrgans/Tissues associated with Camk4 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >24 publications with Camk4 and Nervous System Diseases
 Brain Diseases Antibodies  >14 publications with Camk4 and Brain Diseases
 Cardiovascular Diseases Antibodies  >13 publications with Camk4 and Cardiovascular Diseases
 Mental Disorders Antibodies  >11 publications with Camk4 and Mental Disorders
 Pain Antibodies  >10 publications with Camk4 and Pain
 Inflammation Antibodies  >8 publications with Camk4 and Inflammation
 Memory Disorders Antibodies  >8 publications with Camk4 and Memory Disorders
 Hypertrophy Antibodies  >7 publications with Camk4 and Hypertrophy
 Learning Disorders Antibodies  >6 publications with Camk4 and Learning Disorders
 Necrosis Antibodies  >6 publications with Camk4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >137 publications with Camk4 and Brain
 Testis Antibodies  >13 publications with Camk4 and Testis
 Thymus Antibodies  >10 publications with Camk4 and Thymus
 Adrenal Gland Antibodies  >2 publications with Camk4 and Adrenal Gland
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