NP_000920.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15.6 kDa
NCBI Official Full Name
calcium-dependent phospholipase A2
NCBI Official Synonym Full Names
phospholipase A2 group V
NCBI Official Synonym Symbols
FRFB; GV-PLA2; PLA2-10; hVPLA(2) [Similar Products]
NCBI Protein Information
calcium-dependent phospholipase A2
UniProt Protein Name
Calcium-dependent phospholipase A2
UniProt Synonym Protein Names
Group V phospholipase A2; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5
NCBI Summary for PLA2G5
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for PLA2G5
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Research Articles on PLA2G5
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Products associated with PLA2G5 recombinant protein
Pathways associated with PLA2G5 recombinant protein
Diseases associated with PLA2G5 recombinant protein
Organs/Tissues associated with PLA2G5 recombinant protein
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