NP_848865.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,729 Da
NCBI Official Full Name
calcium-responsive transactivator
NCBI Official Synonym Full Names
SS18, nBAF chromatin remodeling complex subunit like 1
NCBI Protein Information
calcium-responsive transactivator
UniProt Protein Name
Calcium-responsive transactivator
UniProt Synonym Protein Names
SS18-like protein 1
UniProt Synonym Gene Names
UniProt Comments for Ss18l1
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.
Research Articles on Ss18l1
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Products associated with Ss18l1 recombinant protein
Diseases associated with Ss18l1 recombinant protein
Organs/Tissues associated with Ss18l1 recombinant protein
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