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CACYBP recombinant protein :: Calcyclin Binding Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143953 CACYBP recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calcyclin Binding (CACYBP), Recombinant Protein

 Also Known As   

Recombinant Human Calcyclin Binding Protein

 Product Synonym Names    CACYBP Human; Calcyclin Binding Protein Human Recombinant; S100A6BP; S100A6 Binding Protein; GIG5; PNAS-107; RP1-102G20.6; SIP; CACYBP; hCacyBP; Siah-interacting protein; MGC87971
 Product Gene Name   

CACYBP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF
 OMIM    606186
 3D Structure    ModBase 3D Structure for Q9HB71
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 Host    E Coli
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 Purity/Purification    Greater than 85% as determined by SDS-PAGE.
 Form/Format    CACYBP Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 0.1M NaCl & 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    CACYBP Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
 Other Notes    Small volumes of CACYBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CACYBP recombinant protein

   Description: CACYBP Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 205 amino acids (1-185a.a.) and having a molecular mass of 23.4 kDa. CACYBP protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Introduction: CACYBP (calcyclin binding protein) participates in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. CACYBP acts as a molecular bridge in ubiquitin E3 complexes. CACYBP is involved in the ubiquitin-mediated degradation of beta-catenin.
 Product Categories/Family for CACYBP recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Calcium Binding Protein
NCBI/Uniprot data below describe general gene information for CACYBP. It may not necessarily be applicable to this product.
 NCBI GI #    60218913
 NCBI GeneID    27101
 NCBI Accession #    NP_001007215.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001007214.1 [Other Products]
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 UniProt Primary Accession #    Q9HB71 [Other Products]
 UniProt Secondary Accession #    O60666; Q5R370; Q5R371; B2ZWH2; B3KSF1 [Other Products]
 UniProt Related Accession #    Q9HB71 [Other Products]
 Molecular Weight    21,228 Da
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 NCBI Official Full Name    calcyclin-binding protein isoform 2
 NCBI Official Synonym Full Names    calcyclin binding protein
 NCBI Official Symbol    CACYBP [Similar Products]
 NCBI Official Synonym Symbols   
SIP; GIG5; PNAS-107; S100A6BP
[Similar Products]
 NCBI Protein Information    calcyclin-binding protein; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein; hCacyBP
 UniProt Protein Name    Calcyclin-binding protein
 UniProt Synonym Protein Names   
S100A6-binding protein; Siah-interacting protein
 Protein Family    Calcyclin-binding protein
 UniProt Gene Name    CACYBP [Similar Products]
 UniProt Synonym Gene Names    S100A6BP; SIP; CacyBP; hCacyBP [Similar Products]
 UniProt Entry Name    CYBP_HUMAN
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 NCBI Summary for CACYBP    The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CACYBP    CACYBP: a nuclear/cytoplasmic protein involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. A possible molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). Interacts with proteins of the S100 family at physiological calcium concentrations. Component of some large E3 complexes and interacts directly with SIAH1, SIAH2 and SKP1A. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q24-q25

Cellular Component: nucleoplasm; neuron projection; nuclear envelope lumen; cytoplasm; beta-catenin destruction complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: positive regulation of DNA replication; cardiac muscle cell differentiation; aging
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 Research Articles on CACYBP    1. Overexpression of CacyBP is associated with glioma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CACYBP recombinant proteinPathways associated with CACYBP recombinant protein
 Reference Product  PubMed Publications
 S100A6 recombinant protein  >21 publications with CACYBP and S100A6
 SIAH1 recombinant protein  >4 publications with CACYBP and SIAH1
 APC recombinant protein  >1 publications with CACYBP and APC
 GSK3B recombinant protein  >1 publications with CACYBP and GSK3B
 Products by Pathway  Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
Diseases associated with CACYBP recombinant proteinOrgans/Tissues associated with CACYBP recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with CACYBP and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >3 publications with CACYBP and Neoplasms, Experimental
 Kidney Diseases Antibodies  >3 publications with CACYBP and Kidney Diseases
 Breast Neoplasms Antibodies  >2 publications with CACYBP and Breast Neoplasms
 Disease Models, Animal Antibodies  >2 publications with CACYBP and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >1 publications with CACYBP and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with CACYBP and Heart Diseases
 Acute Kidney Injury Antibodies  >1 publications with CACYBP and Acute Kidney Injury
 Liver Neoplasms Antibodies  >1 publications with CACYBP and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with CACYBP and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with CACYBP and Brain
 Stomach Antibodies  >9 publications with CACYBP and Stomach
 Blood Antibodies  >5 publications with CACYBP and Blood
 Kidney Antibodies  >4 publications with CACYBP and Kidney
 Ascites Antibodies  >4 publications with CACYBP and Ascites
 Nerve Antibodies  >3 publications with CACYBP and Nerve
 Lymph Node Antibodies  >3 publications with CACYBP and Lymph Node
 Muscle Antibodies  >3 publications with CACYBP and Muscle
 Lymph Antibodies  >3 publications with CACYBP and Lymph
 Uterus Antibodies  >2 publications with CACYBP and Uterus
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