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CALR recombinant protein :: Calreticulin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143954 CALR recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calreticulin, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Calreticulin

 Product Synonym Names    cC1qR; CRT; FLJ26680; RO; SSA; CRP55; Calreticulin; ERp60; CRTC; CALR
 Product Gene Name   

CALR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MEPAVYFKEQ FLDGDGWTSR WIESKHKSDF GKFVLSSGKF YGDEEKDKGL QTSQDARFYA LSASFEPFSN KGQTLVVQFT VKHEQNIDCG GGYVKLFPNS LDQTDMHGDS EYNIMFGPDI CGPGTKKVHV IFNYKGKNVL INKDIRCKDD EFTHLYTLIV RPDNTYEVKI DNSQVESGSL EDDWDFLPPK KIKDPDASKP EDWDERAKID DPTDSKPEDW DKPEHIPDPD AKKPEDWDEE MDGEWEPPVI QNPEYKGEWK PRQIDNPDYK GTWIHPEIDN PEYSPDPSIY AYDNFGVLGL DLWQVKSGTI FDNFLITNDE AYAEEFGNET WGVTKAAEKQ MKDKQDEEQR LKEEEEDKKR KEEEEAEDKE DDEDKDEDEE DEEDKEEDEE EDVPGQAKDE L.
 OMIM    109091
 3D Structure    ModBase 3D Structure for P27797
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 Purity/Purification    Greater than 85% as determined by SDS-PAGE.
 Form/Format    1mg/ml solution containing 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl and 10% glycerol.
Sterile filtered colorless solution.
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 Source    E Coli
    
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of CALR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CALR recombinant protein

   Description: CALR Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 421 amino acids (18-417 a.a.) and having a molecular mass of 48.7 kDa. CALR protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.

Introduction: CALR is a multifunctional protein that acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin is localized in the nucleus, and participates in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is nearly identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CALR binds to antibodies in specific sera of systemic lupus and Sjogren patients which have anti-Ro/SSA antibodies, it is well conserved among species, and it is positioned in the endoplasmic and sarcoplasmic reticulum where it binds calcium. The amino terminus of CALR interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. CALR reduces the binding of androgen receptor to its hormone-responsive DNA element and inhibits androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Therefore, CALR acts as a significant modulator of the regulation of gene transcription by nuclear hormone receptors.
 Product Categories/Family for CALR recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for CALR. It may not necessarily be applicable to this product.
 NCBI GI #    4757900
 NCBI GeneID    811
 NCBI Accession #    NP_004334.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004343.3 [Other Products]
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 UniProt Primary Accession #    P27797 [Other Products]
 UniProt Secondary Accession #    Q6IAT4; Q9UDG2 [Other Products]
 UniProt Related Accession #    P27797 [Other Products]
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 NCBI Official Full Name    calreticulin
 NCBI Official Synonym Full Names    calreticulin
 NCBI Official Symbol    CALR [Similar Products]
 NCBI Official Synonym Symbols   
RO; CRT; SSA; cC1qR; HEL-S-99n
[Similar Products]
 NCBI Protein Information    calreticulin; CRP55; ERp60; HACBP; Sicca syndrome antigen A (autoantigen Ro; calreticulin); calregulin; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; grp60
 UniProt Protein Name    Calreticulin
 UniProt Synonym Protein Names   
CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60
 Protein Family    Calreticulin
 UniProt Gene Name    CALR [Similar Products]
 UniProt Synonym Gene Names    CRTC; ERp60 [Similar Products]
 UniProt Entry Name    CALR_HUMAN
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 NCBI Summary for CALR    Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CALR    Calreticulin: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57. Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Belongs to the calreticulin family.

Protein type: Secreted; Nuclear receptor co-regulator; Calcium-binding; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: Golgi apparatus; extracellular space; cell surface; focal adhesion; smooth endoplasmic reticulum; sarcoplasmic reticulum lumen; endoplasmic reticulum; endoplasmic reticulum lumen; acrosome; extracellular region; cytosol; polysome; proteinaceous extracellular matrix; membrane; perinuclear region of cytoplasm; cytoplasm; intracellular; nucleus; external side of plasma membrane

Molecular Function: hormone binding; zinc ion binding; complement component C1q binding; unfolded protein binding; calcium ion binding; peptide binding; mRNA binding; integrin binding; protein binding; DNA binding; androgen receptor binding; iron ion binding; chaperone binding; ubiquitin protein ligase binding; carbohydrate binding; glycoprotein binding

Biological Process: protein maturation via protein folding; protein folding; regulation of meiosis; negative regulation of transcription from RNA polymerase II promoter; cardiac muscle cell differentiation; response to estradiol stimulus; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of transcription, DNA-dependent; positive regulation of phagocytosis; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein export from nucleus; cortical actin cytoskeleton organization and biogenesis; cell cycle arrest; response to drug; receptor-mediated endocytosis; negative regulation of steroid hormone receptor signaling pathway; protein stabilization; unfolded protein response; positive regulation of cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; response to testosterone stimulus; post-translational protein modification; peptide antigen assembly with MHC class I protein complex; cellular calcium ion homeostasis; negative regulation of retinoic acid receptor signaling pathway; negative regulation of neuron differentiation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; glucocorticoid receptor signaling pathway; negative regulation of translation; sequestering of calcium ion; protein amino acid N-linked glycosylation via asparagine; spermatogenesis; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication

Disease: Myelofibrosis; Thrombocythemia 1
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 Research Articles on CALR    1. Urinary calreticulin, annexin A2, and annexin A3 are very likely a panel of biomarkers with potential value for upper tract urothelial carcinoma diagnosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CALR recombinant proteinPathways associated with CALR recombinant protein
 Reference Product  PubMed Publications
 PDIA3 recombinant protein  >3 publications with CALR and PDIA3
 CANX recombinant protein  >2 publications with CALR and CANX
 P4HB recombinant protein  >1 publications with CALR and P4HB
 HLA-B recombinant protein  >1 publications with CALR and HLA-B
 Products by Pathway  Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Assembly Of Viral Components At The Budding Site Pathway antibodies  Assembly Of Viral Components At The Budding Site Pathway Diagram
Diseases associated with CALR recombinant proteinOrgans/Tissues associated with CALR recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >11 publications with CALR and Anemia
 Fibrosis Antibodies  >5 publications with CALR and Fibrosis
 Disease Models, Animal Antibodies  >4 publications with CALR and Disease Models, Animal
 Liver Neoplasms Antibodies  >3 publications with CALR and Liver Neoplasms
 Hepatomegaly Antibodies  >3 publications with CALR and Hepatomegaly
 Cognition Disorders Antibodies  >3 publications with CALR and Cognition Disorders
 Cardiovascular Diseases Antibodies  >3 publications with CALR and Cardiovascular Diseases
 Brain Diseases Antibodies  >3 publications with CALR and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with CALR and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with CALR and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with CALR and Blood
 Brain Antibodies  >26 publications with CALR and Brain
 Nerve Antibodies  >22 publications with CALR and Nerve
 Bone Antibodies  >22 publications with CALR and Bone
 Bone Marrow Antibodies  >20 publications with CALR and Bone Marrow
 Intestine Antibodies  >13 publications with CALR and Intestine
 Ganglia Antibodies  >7 publications with CALR and Ganglia
 Vascular Antibodies  >7 publications with CALR and Vascular
 Lung Antibodies  >6 publications with CALR and Lung
 Liver Antibodies  >5 publications with CALR and Liver
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