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Calr recombinant protein :: Calreticulin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS957196
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $195 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $195 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $255 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $415 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $660 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,050 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,295 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,910 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,960 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,520 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calreticulin, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Calreticulin

 Product Synonym Names    CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP
 Product Gene Name   

Calr recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS957196 COA    COA PDF
 Sequence Positions    18-416. Full length of the mature protein.
 Sequence    DPAIYFKEQF LDGDAWTNRW VESKHKSDFG KFVLSSGKFY GDLEKDKGLQ TSQDARFYAL SAKFEPFSNK GQTLVVQFTV KHEQNIDCGG GYVKLFPSGL DQKDMHGDSE YNIMFGPDIC GPGTKKVHVI FNYKGKNVLI NKDIRCKDDE FTHLYTLIVR PDNTYEVKID NSQVESGSLE DDWDFLPPKK IKDPDAAKPE DWDERAKIDD PTDSKPEDWD KPEHIPDPDA KKPEDWDEEM DGEWEPPVIQ NPEYKGEWKP RQIDNPDYKG TWIHPEIDNP EYSPDANIYA YDSFAVLGLD LWQVKSGTIF DNFLITNDEA YAEEFGNETW GVTKAAEKQM KDKQDEEQRL KEEEEDKKRK EEEEAEDKED DDDRDEDEDE EDEKEEDEEE SPGQAKDEL
 3D Structure    ModBase 3D Structure for P14211
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Calr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Calr recombinant protein

   Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.
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 SDS-Page of Calr recombinant protein    Calr recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Calr. It may not necessarily be applicable to this product.
 NCBI GI #    6680836
 NCBI GeneID    12317
 NCBI Accession #    NP_031617.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007591.3 [Other Products]
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 UniProt Primary Accession #    P14211 [Other Products]
 UniProt Secondary Accession #    Q3TVD2 [Other Products]
 UniProt Related Accession #    P14211 [Other Products]
 Molecular Weight    73.7kD
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 NCBI Official Full Name    calreticulin
 NCBI Official Synonym Full Names    calreticulin
 NCBI Official Symbol    Calr [Similar Products]
 NCBI Official Synonym Symbols   
CRT; Calregulin
[Similar Products]
 NCBI Protein Information    calreticulin
 UniProt Protein Name    Calreticulin
 UniProt Synonym Protein Names   
CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP
 Protein Family    Calreticulin
 UniProt Gene Name    Calr [Similar Products]
 UniProt Synonym Gene Names    ERp60 [Similar Products]
 UniProt Entry Name    CALR_MOUSE
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 UniProt Comments for Calr    Calreticulin: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57. Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Belongs to the calreticulin family.

Protein type: Motility/polarity/chemotaxis; Calcium-binding; Secreted; Nuclear receptor co-regulator; Secreted, signal peptide

Cellular Component: acrosome; cell surface; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; external side of plasma membrane; extracellular matrix; extracellular space; focal adhesion; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus; perinuclear region of cytoplasm; polysome; protein complex; sarcoplasmic reticulum; smooth endoplasmic reticulum

Molecular Function: androgen receptor binding; calcium ion binding; carbohydrate binding; glycoprotein binding; hormone binding; integrin binding; iron ion binding; metal ion binding; mRNA binding; peptide binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: cell cycle arrest; cortical actin cytoskeleton organization and biogenesis; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of steroid hormone receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translation; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of phagocytosis; protein export from nucleus; protein folding; protein stabilization; regulation of meiosis
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Product References and Citations for Calr recombinant protein

   Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP) , a major calcium binding ER/SR protein.Smith M.J., Koch G.L.E.EMBO J. 8:3581-3586(1989) Determination of the sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a novel nested set method.Mazzarella R.A., Gold P., Cunningham M., Green M.Gene 120:217-225(1992) Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.Merrick B.A., Patterson R.M., Wichter L.L., He C., Selkirk J.K.Electrophoresis 15:735-745(1994) Lubec G., Kang S.U., Sunyer B., Chen W.-Q.Submitted (JAN-2009) to UniProtKB The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.Dupuis M., Schaerer E., Krause K.-H., Tschopp J.J. Exp. Med. 177:1-7(1993) Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.Timchenko L.T., Salisbury E., Wang G.-L., Nguyen H., Albrecht J.H., Hershey J.W., Timchenko N.A.J. Biol. Chem. 281:32806-32819(2006) Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.Kozlov G., Bastos-Aristizabal S., Maattanen P., Rosenauer A., Zheng F., Killikelly A., Trempe J.F., Thomas D.Y., Gehring K.J. Biol. Chem. 285:35551-35557(2010) A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome.Bhattacharya R., Devi M.S., Dhople V.M., Jesudasan R.A.BMC Cell Biol. 14:50-50(2013) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013) Structural basis of carbohydrate recognition by calreticulin.Kozlov G., Pocanschi C.L., Rosenauer A., Bastos-Aristizabal S., Gorelik A., Williams D.B., Gehring K.J. Biol. Chem. 285:38612-38620(2010) Structural and functional relationships between the lectin and arm domains of calreticulin.Pocanschi C.L., Kozlov G., Brockmeier U., Brockmeier A., Williams D.B., Gehring K.J. Biol. Chem. 286:27266-27277(2011)
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 Research Articles on Calr    1. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin-substrate interactions and as key determinants of PLC dynamics.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Calr recombinant proteinDiseases associated with Calr recombinant protein
 Reference Product  PubMed Publications
 Pdia3 recombinant protein  >5 publications with Calr and Pdia3
 Pdia4 recombinant protein  >2 publications with Calr and Pdia4
 Hyou1 recombinant protein  >2 publications with Calr and Hyou1
 Hsp90b1 recombinant protein  >2 publications with Calr and Hsp90b1
 P4hb recombinant protein  >1 publications with Calr and P4hb
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with Calr and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >13 publications with Calr and Neoplasms, Experimental
 Fibrosis Antibodies  >9 publications with Calr and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >7 publications with Calr and Cell Transformation, Neoplastic
 Inflammation Antibodies  >6 publications with Calr and Inflammation
 Disease Models, Animal Antibodies  >5 publications with Calr and Disease Models, Animal
 Hyperplasia Antibodies  >4 publications with Calr and Hyperplasia
 Liver Diseases Antibodies  >4 publications with Calr and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with Calr and Liver Neoplasms
 Hepatomegaly Antibodies  >3 publications with Calr and Hepatomegaly
Organs/Tissues associated with Calr recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with Calr and Blood
 Bone Antibodies  >49 publications with Calr and Bone
 Bone Marrow Antibodies  >47 publications with Calr and Bone Marrow
 Brain Antibodies  >29 publications with Calr and Brain
 Intestine Antibodies  >15 publications with Calr and Intestine
 Lung Antibodies  >8 publications with Calr and Lung
 Liver Antibodies  >7 publications with Calr and Liver
 Kidney Antibodies  >4 publications with Calr and Kidney
 Eye Antibodies  >4 publications with Calr and Eye
 Muscle Antibodies  >4 publications with Calr and Muscle
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