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CASQ2 recombinant protein :: Calsequestrin-2 (CASQ2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1028255 CASQ2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $795 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,035 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,170 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,215 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,280 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,310 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,370 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,660 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,885 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,940 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,085 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,500 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calsequestrin-2 (CASQ2), Recombinant Protein

 Also Known As   

Recombinant Human Calsequestrin-2 (CASQ2)

 Product Gene Name   

CASQ2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    20-399aa, Full Length of Mature Protein
 Sequence    EEGLNFPTYD GKDRVVSLSE KNFKQVLKKY DLLCLYYHEP VSSDKVTQKQ FQLKEIVLEL VAQVLEHKAI GFVMVDAKKE AKLAKKLGFD EEGSLYILKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII SSKLEVQAFE RIEDYIKLIG FFKSEDSEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPN KPYTEEELVE FVKEHQRPTL RRLRPEEMFE TWEDDLNGIH IVAFAEKSDP DGYEFLEILK QVARDNTDNP DLSILWIDPD DFPLLVAYWE KTFKIDLFRP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDEDD DDDDNSDEED NDDSDDDDDE
 OMIM    114251
 3D Structure    ModBase 3D Structure for O14958
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CASQ2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CASQ2 recombinant protein

   This protein specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
NCBI/Uniprot data below describe general gene information for CASQ2. It may not necessarily be applicable to this product.
 NCBI GI #    119395727
 NCBI GeneID    845
 NCBI Accession #    NP_001223.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001232.3 [Other Products]
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 UniProt Primary Accession #    O14958 [Other Products]
 UniProt Secondary Accession #    Q5T1D2; Q8TBW8; B2R7M6; B4DIB0 [Other Products]
 UniProt Related Accession #    O14958 [Other Products]
 Molecular Weight    38,269 Da
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 NCBI Official Full Name    calsequestrin-2
 NCBI Official Synonym Full Names    calsequestrin 2
 NCBI Official Symbol    CASQ2 [Similar Products]
 NCBI Official Synonym Symbols   
PDIB2
[Similar Products]
 NCBI Protein Information    calsequestrin-2
 UniProt Protein Name    Calsequestrin-2
 UniProt Synonym Protein Names   
Calsequestrin, cardiac muscle isoform
 Protein Family    Calsequestrin
 UniProt Gene Name    CASQ2 [Similar Products]
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 NCBI Summary for CASQ2    The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CASQ2    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
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 Research Articles on CASQ2    1. We show for the first time a heterozygous CASQ2 variant causing autosomal dominant CPVT in a large family with a severe phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CASQ2 recombinant proteinPathways associated with CASQ2 recombinant protein
 Reference Product  PubMed Publications
 RYR2 recombinant protein  >87 publications with CASQ2 and RYR2
 RYR1 recombinant protein  >62 publications with CASQ2 and RYR1
 TRDN recombinant protein  >12 publications with CASQ2 and TRDN
 ASPH recombinant protein  >8 publications with CASQ2 and ASPH
 PLN recombinant protein  >6 publications with CASQ2 and PLN
 ANKRD1 recombinant protein  >1 publications with CASQ2 and ANKRD1
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
Diseases associated with CASQ2 recombinant proteinOrgans/Tissues associated with CASQ2 recombinant protein
 Disease Name  Pubmed Publications
 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies  >18737 publications with CASQ2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY
 Tachycardia, Ventricular Antibodies  >98 publications with CASQ2 and Tachycardia, Ventricular
 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 2 Antibodies  >34 publications with CASQ2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 2
 Polymorphic catecholergic ventricular tachycardia Antibodies  >34 publications with CASQ2 and Polymorphic catecholergic ventricular tachycardia
 Disease Models, Animal Antibodies  >17 publications with CASQ2 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >5 publications with CASQ2 and Heart Defects, Congenital
 Neurobehavioral Manifestations Antibodies  >5 publications with CASQ2 and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >5 publications with CASQ2 and Congenital Abnormalities
 Inflammation Antibodies  >3 publications with CASQ2 and Inflammation
 Atrophy Antibodies  >2 publications with CASQ2 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >112 publications with CASQ2 and Heart
 Muscle Antibodies  >96 publications with CASQ2 and Muscle
 Lung Antibodies  >13 publications with CASQ2 and Lung
 Brain Antibodies  >5 publications with CASQ2 and Brain
 Eye Antibodies  >4 publications with CASQ2 and Eye
 Embryonic Tissue Antibodies  >3 publications with CASQ2 and Embryonic Tissue
 Skin Antibodies  >1 publications with CASQ2 and Skin
 Testis Antibodies  >1 publications with CASQ2 and Testis
 Mouth Antibodies  >1 publications with CASQ2 and Mouth
 Placenta Antibodies  >1 publications with CASQ2 and Placenta
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