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CA9 recombinant protein :: Carbonic Anhydrase IX (CA9) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011410 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) CA9 recombinant protein
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Carbonic Anhydrase IX (CA9), Recombinant Protein

 Also Known As   

Recombinant Carbonic Anhydrase IX (CA9)

 Product Gene Name   

CA9 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Carbonic Anhydrase IX (CA9) (MBS2006971)
Antigen: Carbonic Anhydrase IX (CA9) (MBS2011410)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEFELRR Q-PL GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGSLKL EDLPTVEAPG DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQL AAFCPALRPL ELLGFQLPPL PELRLRNNGH SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT VEGHRFPAEI HVVHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM LSAKQLHTLS DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSCL AAGD
 Chromosome Location    Chromosome: 19; NC_000019.9 (4174106..4182596, complement). Location: 19p13.3
 OMIM    606211
 3D Structure    ModBase 3D Structure for Q8N6T7
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Pro59~Asp414 (Accession # Q8N6T7) with two N-terminal Tags, His-tag and T7-tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of CA9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CA9 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for CA9 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for CA9. It may not necessarily be applicable to this product.
 NCBI GI #    300797597
 NCBI GeneID    51548
 NCBI Accession #    NP_001180214.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193285.1 [Other Products]
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 UniProt Primary Accession #    Q8N6T7 [Other Products]
 UniProt Secondary Accession #    O75291; Q6IAF5; Q6PK99; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1; B2RCD0 [Other Products]
 UniProt Related Accession #    Q8N6T7 [Other Products]
 Molecular Weight    43.3kDa
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 NCBI Official Full Name    NAD-dependent protein deacetylase sirtuin-6 isoform 2
 NCBI Official Synonym Full Names    sirtuin 6
 NCBI Official Symbol    SIRT6 [Similar Products]
 NCBI Official Synonym Symbols   
SIR2L6
[Similar Products]
 NCBI Protein Information    NAD-dependent protein deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; regulatory protein SIR2 homolog 6; NAD-dependent deacetylase sirtuin-6
 UniProt Protein Name    NAD-dependent protein deacetylase sirtuin-6
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 6; SIR2-like protein 6
 Protein Family    Carbonic anhydrase
 UniProt Gene Name    SIRT6 [Similar Products]
 UniProt Synonym Gene Names    SIR2L6 [Similar Products]
 UniProt Entry Name    SIR6_HUMAN
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 NCBI Summary for CA9    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
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 UniProt Comments for CA9    SIRT6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.2.31; Deacetylase; Transferase; EC 3.5.1.-

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nuclear telomeric heterochromatin; nucleolus; nucleus

Molecular Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; zinc ion binding; NAD-dependent histone deacetylase activity; chromatin binding; NAD+ ADP-ribosyltransferase activity

Biological Process: protein amino acid ADP-ribosylation; histone deacetylation
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 Research Articles on CA9    1. Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CA9 recombinant proteinDiseases associated with CA9 recombinant protein
 Products by Pathway  Pathway Diagram
 SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway antibodies  SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >24 publications with CA9 and Inflammation
 Neoplasms Antibodies  >17 publications with CA9 and Neoplasms
 Liver Diseases Antibodies  >9 publications with CA9 and Liver Diseases
 Necrosis Antibodies  >8 publications with CA9 and Necrosis
 Hypertrophy Antibodies  >6 publications with CA9 and Hypertrophy
 Cardiomegaly Antibodies  >3 publications with CA9 and Cardiomegaly
 Carcinoma, Hepatocellular Antibodies  >3 publications with CA9 and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >3 publications with CA9 and Atherosclerosis
 Immune System Diseases Antibodies  >3 publications with CA9 and Immune System Diseases
 Breast Neoplasms Antibodies  >2 publications with CA9 and Breast Neoplasms
Organs/Tissues associated with CA9 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >17 publications with CA9 and Liver
 Blood Antibodies  >15 publications with CA9 and Blood
 Brain Antibodies  >13 publications with CA9 and Brain
 Heart Antibodies  >10 publications with CA9 and Heart
 Muscle Antibodies  >8 publications with CA9 and Muscle
 Lung Antibodies  >5 publications with CA9 and Lung
 Skin Antibodies  >4 publications with CA9 and Skin
 Embryonic Tissue Antibodies  >4 publications with CA9 and Embryonic Tissue
 Prostate Antibodies  >3 publications with CA9 and Prostate
 Kidney Antibodies  >3 publications with CA9 and Kidney
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