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CA9 recombinant protein :: Carbonic anhydrase 9 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS959569 (PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed)
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Carbonic anhydrase 9 (CA9), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Carbonic anhydrase 9

 Product Synonym Names    Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MNP; 54/58N; Renal cell carcinoma-associated antigen G250; R; CC-associated antigen G250; pMW1
 Product Gene Name   

CA9 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS959569 COA    COA PDF
 Sequence Positions    64-399. Partial.
 Sequence    DLPSEEDSPR EEDPPGEEDL PGEEDLPGEE DLPEVKPKSE EEGSLKLEDL PTVEAPGDPQ EPQNNAHRDK EGDDQSHWRY GGDPPWPRVS PACAGRFQSP VDIRPQLAAF CPALRPLELL GFQLPPLPEL RLRNNGHSVQ LTLPPGLEMA LGPGREYRAL QLHLHWGAAG RPGSEHTVEG HRFPAEIHVV HLSTAFARVD EALGRPGGLA VLAAFLEEGP EENSAYEQLL SRLEEIAEEG SETQVPGLDI SALLPSDFSR YFQYEGSLTT PPCAQGVIWT VFNQTVMLSA KQLHTLSDTL WGPGDSRLQL NFRATQPLNG RVIEASFPAG VDSSPR
 OMIM    603179
 3D Structure    ModBase 3D Structure for Q16790
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CA9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CA9 recombinant protein

   Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
 Product Categories/Family for CA9 recombinant protein    Metabolism
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 SDS-PAGE of CA9 recombinant protein    CA9 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CA9. It may not necessarily be applicable to this product.
 NCBI GI #    169636420
 NCBI GeneID    768
 NCBI Accession #    NP_001207.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001216.2 [Other Products]
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 UniProt Primary Accession #    Q16790 [Other Products]
 UniProt Secondary Accession #    Q5T4R1 [Other Products]
 UniProt Related Accession #    Q16790 [Other Products]
 Molecular Weight    64.2kD
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 NCBI Official Full Name    carbonic anhydrase 9
 NCBI Official Synonym Full Names    carbonic anhydrase IX
 NCBI Official Symbol    CA9 [Similar Products]
 NCBI Official Synonym Symbols   
MN; CAIX
[Similar Products]
 NCBI Protein Information    carbonic anhydrase 9
 UniProt Protein Name    Carbonic anhydrase 9
 UniProt Synonym Protein Names   
Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1
 Protein Family    Carbonic anhydrase
 UniProt Gene Name    CA9 [Similar Products]
 UniProt Synonym Gene Names    G250; MN; CA-IX; CAIX; RCC-associated antigen G250 [Similar Products]
 UniProt Entry Name    CAH9_HUMAN
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 NCBI Summary for CA9    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]
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 UniProt Comments for CA9    CA9: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Forms oligomers linked by disulfide bonds. By hypoxia. Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family.

Protein type: Lyase; Nucleolus; Energy Metabolism - nitrogen; EC 4.2.1.1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: basolateral plasma membrane; integral to membrane; microvillus membrane; nucleolus; plasma membrane

Molecular Function: carbonate dehydratase activity; zinc ion binding

Biological Process: bicarbonate transport; morphogenesis of an epithelium; one-carbon compound metabolic process; response to drug; response to testosterone stimulus; secretion
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Product References and Citations for CA9 recombinant protein

   Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment.Pastorek J., Pastorekova S., Callebaut I., Mornon J.-P., Zelnik V., Opavsky R., Zat'Ovicova M., Liao S., Portetelle D., Stanbridge E.J., Zavada J., Burny A., Kettmann R.Oncogene 9:2877-2888(1994) Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250.Grabmaier K., Vissers J.L.M., De Weijert M.C.A., Oosterwijk-Wakka J.C., Van Bokhoven A., Brakenhoff R.H., Noessner E., Mulders P.A., Merkx G., Figdor C.G., Adema G.J., Oosterwijk E.3.0.CO;2-Q>Int. J. Cancer 85:865-870(2000) DNA sequence and analysis of human chromosome 9.Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.Nature 429:369-374(2004)
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 Research Articles on CA9    1. CAIX expression is increased in hypoxia to compensate for the decrease in its activity produced by a low extracellular pH. A major function of CAIX is to lower the extracellular pH.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CA9 recombinant proteinPathways associated with CA9 recombinant protein
 Reference Product  PubMed Publications
 HIF1A recombinant protein  >172 publications with CA9 and HIF1A
 EGFR recombinant protein  >29 publications with CA9 and EGFR
 CTNNB1 recombinant protein  >5 publications with CA9 and CTNNB1
 TP53 recombinant protein  >3 publications with CA9 and TP53
 EP300 recombinant protein  >3 publications with CA9 and EP300
 ARNT recombinant protein  >3 publications with CA9 and ARNT
 SLC4A4 recombinant protein  >2 publications with CA9 and SLC4A4
 HIF3A recombinant protein  >2 publications with CA9 and HIF3A
 CREBBP recombinant protein  >1 publications with CA9 and CREBBP
 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies  Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
 Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway antibodies  Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway Diagram
 Reversible Hydration Of Carbon Dioxide Pathway antibodies  Reversible Hydration Of Carbon Dioxide Pathway Diagram
Diseases associated with CA9 recombinant proteinOrgans/Tissues associated with CA9 recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >265 publications with CA9 and Adenocarcinoma
 Kidney Diseases Antibodies  >198 publications with CA9 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >146 publications with CA9 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >88 publications with CA9 and Breast Neoplasms
 Anoxia Antibodies  >83 publications with CA9 and Anoxia
 Neoplasms, Experimental Antibodies  >74 publications with CA9 and Neoplasms, Experimental
 Necrosis Antibodies  >56 publications with CA9 and Necrosis
 Neoplasm Invasiveness Antibodies  >54 publications with CA9 and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >53 publications with CA9 and Lung Neoplasms
 Nervous System Diseases Antibodies  >43 publications with CA9 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >205 publications with CA9 and Kidney
 Blood Antibodies  >159 publications with CA9 and Blood
 Lung Antibodies  >64 publications with CA9 and Lung
 Brain Antibodies  >36 publications with CA9 and Brain
 Cervix Antibodies  >30 publications with CA9 and Cervix
 Bone Antibodies  >26 publications with CA9 and Bone
 Stomach Antibodies  >14 publications with CA9 and Stomach
 Pancreas Antibodies  >14 publications with CA9 and Pancreas
 Uterus Antibodies  >10 publications with CA9 and Uterus
 Intestine Antibodies  >10 publications with CA9 and Intestine
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