Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow PLN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • EIF4EBP1 Antibody
 • S1PR2 Antibody
 • Listeria Monocytogenes Internalin  (inlE) Recombinant Protein
 • ABCA4 Antibody
 • hepatitis A virus cellular receptor 2 (HAVCR2) ELISA Kit
 • Ribosomal Protein S6 (rpsF) Antibody
 • HBsAg Antibody
 • VPS35-MEM3 Antibody
 • lamin B1 (LMNB1) Antibody
 • Ataxia Telangiectasia Mutated (ATM) ELISA Kit
 • PCP ELISA Kit
 • Lymphocyte Antibody
 • A disintegrin and metalloproteinase with thrombospondin moti... ELISA Kit
 • Cortisol ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PLN recombinant protein :: Cardiac phospholamban (PLN) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950658
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $445 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $585 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $645 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $780 +1 FREE 8GB USB
1 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,020 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,430 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,560 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,925 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cardiac phospholamban (PLN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Cardiac phospholamban (PLN)

 Product Gene Name   

PLN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    1-52@aa, Full length protein
 Sequence    MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL
 OMIM    172405
 3D Structure    ModBase 3D Structure for P26678
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PLN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for PLN recombinant protein

   This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
Section Bar
 SDS-Page of PLN recombinant protein    PLN recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PLN. It may not necessarily be applicable to this product.
 NCBI GI #    4505887
 NCBI GeneID    5350
 NCBI Accession #    NP_002658.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002667.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P26678 [Other Products]
 UniProt Related Accession #    P26678 [Other Products]
 Molecular Weight    6,109 Da
Table BarTOPTable Bar
 NCBI Official Full Name    cardiac phospholamban
 NCBI Official Synonym Full Names    phospholamban
 NCBI Official Symbol    PLN [Similar Products]
 NCBI Official Synonym Symbols   
PLB; CMD1P; CMH18
[Similar Products]
 NCBI Protein Information    cardiac phospholamban
 UniProt Protein Name    Cardiac phospholamban
 Protein Family    Cardiac phospholamban
 UniProt Gene Name    PLN [Similar Products]
 UniProt Synonym Gene Names    PLB; PLB [Similar Products]
Section Bar
 NCBI Summary for PLN    The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Section Bar
 UniProt Comments for PLN    Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Table BarTOPTable Bar
 Research Articles on PLN    1. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with PLN recombinant proteinPathways associated with PLN recombinant protein
 Reference Product  PubMed Publications
 SLN recombinant protein  >21 publications with PLN and SLN
 ATP2A2 recombinant protein  >16 publications with PLN and ATP2A2
 ATP2A1 recombinant protein  >3 publications with PLN and ATP2A1
 DMPK recombinant protein  >2 publications with PLN and DMPK
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
Diseases associated with PLN recombinant proteinOrgans/Tissues associated with PLN recombinant protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >100 publications with PLN and Heart Diseases
 Neoplasms Antibodies  >98 publications with PLN and Neoplasms
 Heart Failure Antibodies  >62 publications with PLN and Heart Failure
 Inflammation Antibodies  >61 publications with PLN and Inflammation
 Drug Toxicity Antibodies  >58 publications with PLN and Drug Toxicity
 Disease Models, Animal Antibodies  >56 publications with PLN and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >54 publications with PLN and Neoplasm Metastasis
 Carcinoma Antibodies  >53 publications with PLN and Carcinoma
 Cardiomyopathies Antibodies  >43 publications with PLN and Cardiomyopathies
 Adenocarcinoma Antibodies  >32 publications with PLN and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >198 publications with PLN and Muscle
 Heart Antibodies  >188 publications with PLN and Heart
 Vascular Antibodies  >77 publications with PLN and Vascular
 Kidney Antibodies  >38 publications with PLN and Kidney
 Pancreas Antibodies  >33 publications with PLN and Pancreas
 Skin Antibodies  >31 publications with PLN and Skin
 Liver Antibodies  >28 publications with PLN and Liver
 Intestine Antibodies  >26 publications with PLN and Intestine
 Lung Antibodies  >26 publications with PLN and Lung
 Brain Antibodies  >23 publications with PLN and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions