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PLN recombinant protein :: Cardiac phospholamban Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950658
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $445 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $585 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $645 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $780 +1 FREE 8GB USB
1 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,020 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,430 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,560 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,925 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cardiac phospholamban (PLN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Cardiac phospholamban

 Product Gene Name   

PLN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-52aa; Full length protein
 Sequence    MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL
 OMIM    172405
 3D Structure    ModBase 3D Structure for P26678
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PLN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PLN recombinant protein

   This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
 Product Categories/Family for PLN recombinant protein    Cardiovascular
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 SDS-Page of PLN recombinant protein    PLN recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PLN. It may not necessarily be applicable to this product.
 NCBI GI #    4505887
 NCBI GeneID    5350
 NCBI Accession #    NP_002658.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002667.3 [Other Products]
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 UniProt Primary Accession #    P26678 [Other Products]
 UniProt Related Accession #    P26678 [Other Products]
 Molecular Weight    33.51kD
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 NCBI Official Full Name    cardiac phospholamban
 NCBI Official Synonym Full Names    phospholamban
 NCBI Official Symbol    PLN [Similar Products]
 NCBI Official Synonym Symbols   
PLB; CMD1P; CMH18
[Similar Products]
 NCBI Protein Information    cardiac phospholamban
 UniProt Protein Name    Cardiac phospholamban
 Protein Family    Cardiac phospholamban
 UniProt Gene Name    PLN [Similar Products]
 UniProt Synonym Gene Names    PLB; PLB [Similar Products]
 UniProt Entry Name    PPLA_HUMAN
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 NCBI Summary for PLN    The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLN    PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

Protein type: Membrane protein, integral; Inhibitor

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: cytosol; endoplasmic reticulum; membrane; mitochondrial membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum membrane; vesicle

Molecular Function: ATPase binding; ATPase inhibitor activity; calcium channel regulator activity; enzyme inhibitor activity; identical protein binding; protein binding

Biological Process: blood circulation; calcium ion transport; cardiac muscle development; cytosolic calcium ion homeostasis; negative regulation of ATPase activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart rate; Notch signaling pathway; protein homooligomerization; regulation of calcium ion transport; regulation of heart contraction; regulation of the force of heart contraction; response to insulin stimulus; response to testosterone stimulus; response to zinc ion

Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18
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 Research Articles on PLN    1. hereditary mutants of phospholamban are associated with heart failure [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLN recombinant proteinPathways associated with PLN recombinant protein
 Reference Product  PubMed Publications
 RYR2 recombinant protein  >31 publications with PLN and RYR2
 SLN recombinant protein  >27 publications with PLN and SLN
 ATP2A2 recombinant protein  >19 publications with PLN and ATP2A2
 ATP2A1 recombinant protein  >3 publications with PLN and ATP2A1
 AKT1 recombinant protein  >1 publications with PLN and AKT1
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
Diseases associated with PLN recombinant proteinOrgans/Tissues associated with PLN recombinant protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >128 publications with PLN and Heart Diseases
 Disease Models, Animal Antibodies  >69 publications with PLN and Disease Models, Animal
 Inflammation Antibodies  >68 publications with PLN and Inflammation
 Hypertrophy Antibodies  >36 publications with PLN and Hypertrophy
 Cardiomegaly Antibodies  >36 publications with PLN and Cardiomegaly
 Kidney Diseases Antibodies  >35 publications with PLN and Kidney Diseases
 Uterine Cervical Neoplasms Antibodies  >29 publications with PLN and Uterine Cervical Neoplasms
 Lung Diseases Antibodies  >27 publications with PLN and Lung Diseases
 Nervous System Diseases Antibodies  >27 publications with PLN and Nervous System Diseases
 Necrosis Antibodies  >23 publications with PLN and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >238 publications with PLN and Muscle
 Heart Antibodies  >233 publications with PLN and Heart
 Vascular Antibodies  >84 publications with PLN and Vascular
 Kidney Antibodies  >47 publications with PLN and Kidney
 Pancreas Antibodies  >39 publications with PLN and Pancreas
 Lung Antibodies  >34 publications with PLN and Lung
 Skin Antibodies  >33 publications with PLN and Skin
 Liver Antibodies  >30 publications with PLN and Liver
 Intestine Antibodies  >29 publications with PLN and Intestine
 Brain Antibodies  >25 publications with PLN and Brain
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