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CSNK1A1 recombinant protein :: Casein Kinase 1 alpha 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145550
SDS-PAGE
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Casein Kinase 1 alpha 1 (CSNK1A1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Casein Kinase 1 alpha 1

 Product Synonym Names    CSNK1A1 Human; Casein Kinase 1 alpha 1 Human Recombinant; Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1; HLCDGP1; PRO2975
 Product Gene Name   

CSNK1A1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM LKQKAAQQAA SSSGQGQQAQ TPTGKQTDKT KSNMKGF
 OMIM    600505
 3D Structure    ModBase 3D Structure for P48729
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 Host    E Coli
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 Purity/Purification    Greater than 80% as determined by SDS-PAGE.
 Form/Format    The CSNK1A1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered colorless solution.
 Concentration    0.5mg/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of CSNK1A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CSNK1A1 recombinant protein

   Description: CSNK1A1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (1-337) and having a molecular mass of 41kDa. CSNK1A1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Caseine Kinase 1 alpha belongs is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. The CK1 isoforms - alpha, beta, gamma, delta, epsilon and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Possibly CSNK1A1 can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. CSNK1A1 also interacts with the Axin complex.
 Product Categories/Family for CSNK1A1 recombinant protein    PROTEIN KINASES; Enzymes; Casein Kinase
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 SDS-PAGE of CSNK1A1 recombinant protein    CSNK1A1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CSNK1A1. It may not necessarily be applicable to this product.
 NCBI GI #    68303575
 NCBI GeneID    1452
 NCBI Accession #    NP_001020276.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025105.2 [Other Products]
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 UniProt Primary Accession #    P48729 [Other Products]
 UniProt Secondary Accession #    Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3; D3DQG0; D3DQG1 [Other Products]
 UniProt Related Accession #    P48729 [Other Products]
 Molecular Weight    37,567 Da
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 NCBI Official Full Name    casein kinase I isoform alpha isoform 1
 NCBI Official Synonym Full Names    casein kinase 1, alpha 1
 NCBI Official Symbol    CSNK1A1 [Similar Products]
 NCBI Official Synonym Symbols   
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
[Similar Products]
 NCBI Protein Information    casein kinase I isoform alpha; CKI-alpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p
 UniProt Protein Name    Casein kinase I isoform alpha
 UniProt Synonym Protein Names   
CK1
 Protein Family    Casein kinase
 UniProt Gene Name    CSNK1A1 [Similar Products]
 UniProt Synonym Gene Names    CKI-alpha [Similar Products]
 UniProt Entry Name    KC1A_HUMAN
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 UniProt Comments for CSNK1A1    CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; EC 2.7.11.1; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: centrosome; membrane; cytoplasm; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity

Biological Process: regulation of cell shape; mitosis; peptidyl-serine phosphorylation; Wnt receptor signaling pathway; cell surface receptor linked signal transduction; cell division; signal transduction; protein amino acid phosphorylation; phagocytosis
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 Research Articles on CSNK1A1    1. Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CSNK1A1 recombinant proteinPathways associated with CSNK1A1 recombinant protein
 Reference Product  PubMed Publications
 CTNNB1 recombinant protein  >5 publications with CSNK1A1 and CTNNB1
 AXIN2 recombinant protein  >1 publications with CSNK1A1 and AXIN2
 TP53 recombinant protein  >1 publications with CSNK1A1 and TP53
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Degradation Of GLI2 By The Proteasome Pathway antibodies  Degradation Of GLI2 By The Proteasome Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
Diseases associated with CSNK1A1 recombinant proteinOrgans/Tissues associated with CSNK1A1 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with CSNK1A1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with CSNK1A1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with CSNK1A1 and Disease Models, Animal
 Esophageal Neoplasms Antibodies  >1 publications with CSNK1A1 and Esophageal Neoplasms
 Cognition Disorders Antibodies  >1 publications with CSNK1A1 and Cognition Disorders
 Anemia Antibodies  >1 publications with CSNK1A1 and Anemia
 Inflammation Antibodies  >1 publications with CSNK1A1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with CSNK1A1 and Lung
 Brain Antibodies  >2 publications with CSNK1A1 and Brain
 Lymph Node Antibodies  >1 publications with CSNK1A1 and Lymph Node
 Bone Antibodies  >1 publications with CSNK1A1 and Bone
 Intestine Antibodies  >1 publications with CSNK1A1 and Intestine
 Skin Antibodies  >1 publications with CSNK1A1 and Skin
 Blood Antibodies  >1 publications with CSNK1A1 and Blood
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