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CSNK2B recombinant protein :: Casein Kinase 2beta Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203147
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Casein Kinase 2beta (CSNK2B), Recombinant Protein

 Also Known As   

Casein Kinase 2beta (CK2beta, 1-215aa), Human, Recombinant, E Coli

 Product Synonym Names    PKCK2 Beta; PKCK2B; CK2N; CSK2B; MGC138222; MGC138224; G5A; Phosvitin; Casein Kinase 2 beta; Casein Kinase 2B; Casein Kinase 2 beta; Casein kinase 2 beta polypeptide; Casein kinase II subunit beta; CK II beta; CK2B; CSNK 2B; CSNK2B; G5A
 Product Gene Name   

CSNK2B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. 20mM Tris pH8.0, 10% glycerol, 0.2M NaCl, 1mM DTT, 1mM EDTA
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CSNK2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CSNK2B recombinant protein

   Casein Kinase 2 (CK2, also called PKCK2) is a ubiquitous Ser/Thr kinase expressed in all eukaryotes. CK2 is a tetramer composed of two catalytic kinase domains, alpha subunits, and two identical regulatory beta subunits. It has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. The beta subunit itself does not have kinase activity, but confers stability to the CK2 alpha subunit and is involved in activity and substrate specificity. Recombinant human CK2beta was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for CSNK2B recombinant protein    Signal Transduction
 Applications Tested/Suitable for CSNK2B recombinant protein   


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 SDS-PAGE of CSNK2B recombinant protein    CSNK2B recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CSNK2B. It may not necessarily be applicable to this product.
 NCBI GI #    23503295
 NCBI GeneID    1460
 NCBI Accession #    NP_001311 [Other Products]
 NCBI GenBank Nucleotide #    NM_001320.6 [Other Products]
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 UniProt Secondary Accession #    P07312; P13862; Q4VX47; B0UXA9 [Other Products]
 UniProt Related Accession #    P67870 [Other Products]
 Molecular Weight    24.9kDa (215aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    casein kinase II subunit beta isoform 1
 NCBI Official Synonym Full Names    casein kinase 2, beta polypeptide
 NCBI Official Symbol    CSNK2B [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    casein kinase II subunit beta; CK II beta; CSNK2B-LY6G5B-532; CSNK2B-LY6G5B-560; Casein kinase II beta subunit; alternative name: G5a, phosvitin; casein kinase II b subunit splicing isoform 318; casein kinase II b subunit splicing isoform 660; casein kinase II b subunit splicing isoform 806; chimera CSNK2B-LY6G5B splicing isoform 532; chimera CSNK2B-LY6G5B splicing isoform 560; protein G5a
 UniProt Protein Name    Casein kinase II subunit beta
 UniProt Synonym Protein Names   
Phosvitin; Protein G5a
 UniProt Gene Name    CSNK2B [Similar Products]
 UniProt Synonym Gene Names    CK2N; G5A; CK II beta [Similar Products]
 UniProt Entry Name    CSK2B_HUMAN
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 NCBI Summary for CSNK2B    This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
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 UniProt Comments for CSNK2B    CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; plasma membrane; protein kinase CK2 complex; PcG protein complex; nucleus; cytosol

Molecular Function: protein domain specific binding; protein serine/threonine kinase activity; identical protein binding; protein binding; metal ion binding; protein kinase regulator activity; transcription factor binding; receptor binding

Biological Process: negative regulation of cell proliferation; axon guidance; positive regulation of activin receptor signaling pathway; cellular protein complex assembly; Wnt receptor signaling pathway; regulation of DNA binding; adiponectin-mediated signaling pathway; mitotic cell cycle; negative regulation of blood vessel endothelial cell migration; signal transduction; regulation of protein kinase activity; protein amino acid phosphorylation
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Product References and Citations for CSNK2B recombinant protein

   Litchfield DW., et al. (2003). Biochem J. 369(1):1-15
unger GM., et al. (2004). Curr. Cancer Drug Targets 4(1):77-84
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 Research Articles on CSNK2B    1. Asymmetric alpha2beta2 tetramers of casein kinase 2 are organized in trimeric rings that correspond to inactive forms of the enzyme. The new crystal structures presented here reveal the symmetric architecture of the isolated active tetramers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CSNK2B recombinant proteinPathways associated with CSNK2B recombinant protein
 Reference Product  PubMed Publications
 CSNK2A2 recombinant protein  >2 publications with CSNK2B and CSNK2A2
 CSNK2A1 recombinant protein  >1 publications with CSNK2B and CSNK2A1
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prometaphase Chromosomes Pathway antibodies  Condensation Of Prometaphase Chromosomes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
Diseases associated with CSNK2B recombinant proteinOrgans/Tissues associated with CSNK2B recombinant protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with CSNK2B and Brain Diseases
 Disease Models, Animal Antibodies  >1 publications with CSNK2B and Disease Models, Animal
 Hepatitis Antibodies  >1 publications with CSNK2B and Hepatitis
 Infertility, Male Antibodies  >1 publications with CSNK2B and Infertility, Male
 Liver Neoplasms Antibodies  >1 publications with CSNK2B and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with CSNK2B and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CSNK2B and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with CSNK2B and Liver
 Prostate Antibodies  >1 publications with CSNK2B and Prostate
 Blood Antibodies  >1 publications with CSNK2B and Blood
 Lung Antibodies  >1 publications with CSNK2B and Lung
 Testis Antibodies  >1 publications with CSNK2B and Testis
 Brain Antibodies  >1 publications with CSNK2B and Brain
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