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CSNK2A1 recombinant protein :: Casein kinase II subunit alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950169
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $910 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,040 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,225 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,290 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,320 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,385 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,900 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,950 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,110 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,505 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Casein kinase II subunit alpha (CSNK2A1), Recombinant Protein

 Also Known As   

Recombinant Human Casein kinase II subunit alpha

 Product Gene Name   

CSNK2A1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-391aa; Full Length
 Sequence    MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN MMSGISSVPT PSPLGPLAGS PVIAAANPLG MPVPAAAGAQ Q
 OMIM    115440
 3D Structure    ModBase 3D Structure for P68400
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CSNK2A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CSNK2A1 recombinant protein

   Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.
 Product Categories/Family for CSNK2A1 recombinant protein    Signal Transduction
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 SDS-PAGE of CSNK2A1 recombinant protein    CSNK2A1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CSNK2A1. It may not necessarily be applicable to this product.
 NCBI GI #    4503095
 NCBI GeneID    1457
 NCBI Accession #    NP_001886.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001895.3 [Other Products]
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 UniProt Primary Accession #    P68400 [Other Products]
 UniProt Secondary Accession #    P19138; P20426; Q14013; Q5U065; B4DYS6; D3DVV8 [Other Products]
 UniProt Related Accession #    P68400; Q8NEV1 [Other Products]
 Molecular Weight    61.11kD
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 NCBI Official Full Name    casein kinase II subunit alpha isoform a
 NCBI Official Synonym Full Names    casein kinase 2, alpha 1 polypeptide
 NCBI Official Symbol    CSNK2A1 [Similar Products]
 NCBI Official Synonym Symbols   
CKII; CK2A1; CSNK2A3
[Similar Products]
 NCBI Protein Information    casein kinase II subunit alpha
 UniProt Protein Name    Casein kinase II subunit alpha
 Protein Family    Casein kinase
 UniProt Gene Name    CSNK2A1 [Similar Products]
 UniProt Synonym Gene Names    CK2A1; CK II alpha [Similar Products]
 UniProt Entry Name    CSK21_HUMAN
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 NCBI Summary for CSNK2A1    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]
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 UniProt Comments for CSNK2A1    CK2A1: an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB).

Protein type: Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; CK2 family

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytosol; nucleus; NuRD complex; PcG protein complex; plasma membrane; Sin3 complex

Molecular Function: ATP binding; Hsp90 protein binding; protein binding; protein N-terminus binding; protein serine/threonine kinase activity

Biological Process: axon guidance; mitotic cell cycle; negative regulation of caspase activity; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of protein catabolic process; positive regulation of Wnt receptor signaling pathway; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; rhythmic process; signal transduction; transcription, DNA-dependent; Wnt receptor signaling pathway
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Product References and Citations for CSNK2A1 recombinant protein

   Molecular cloning of the human casein kinase II alpha subunit.Meisner H., Heller-Harrison R., Buxton J., Czech M.P.Biochemistry 28:4072-4076(1989)
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 Research Articles on CSNK2A1    1. our findings provide new insights on the potential relevance of the CK2-mediated phosphorylation of B23/NPM in cancer cells, revealing at the same time the potentialities of its pharmacological manipulation for cancer therapy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CSNK2A1 recombinant proteinDiseases associated with CSNK2A1 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >1 publications with CSNK2A1 and JUN
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >2 publications with CSNK2A1 and Neoplasms, Experimental
 Brain Diseases Antibodies  >2 publications with CSNK2A1 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with CSNK2A1 and Nervous System Diseases
 Anemia, Hemolytic Antibodies  >1 publications with CSNK2A1 and Anemia, Hemolytic
 Breast Neoplasms Antibodies  >1 publications with CSNK2A1 and Breast Neoplasms
 Infertility, Male Antibodies  >1 publications with CSNK2A1 and Infertility, Male
 Oligospermia Antibodies  >1 publications with CSNK2A1 and Oligospermia
 Fever Antibodies  >1 publications with CSNK2A1 and Fever
 Leukemia-Lymphoma, Adult T-Cell Antibodies  >1 publications with CSNK2A1 and Leukemia-Lymphoma, Adult T-Cell
 Weight Gain Antibodies  >1 publications with CSNK2A1 and Weight Gain
Organs/Tissues associated with CSNK2A1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with CSNK2A1 and Lung
 Bone Antibodies  >2 publications with CSNK2A1 and Bone
 Blood Antibodies  >2 publications with CSNK2A1 and Blood
 Brain Antibodies  >2 publications with CSNK2A1 and Brain
 Bone Marrow Antibodies  >1 publications with CSNK2A1 and Bone Marrow
 Connective Tissue Antibodies  >1 publications with CSNK2A1 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with CSNK2A1 and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with CSNK2A1 and Lymph Node
 Mammary Gland Antibodies  >1 publications with CSNK2A1 and Mammary Gland
 Testis Antibodies  >1 publications with CSNK2A1 and Testis
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