NP_071639.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,632 Da
NCBI Official Full Name
caspase recruitment domain-containing protein 9
NCBI Official Synonym Full Names
caspase recruitment domain family, member 9
NCBI Protein Information
caspase recruitment domain-containing protein 9
UniProt Protein Name
Caspase recruitment domain-containing protein 9
UniProt Synonym Gene Names
NCBI Summary for Card9
interacts with the CARD activation domain of BCL10; activates NF-kappaB signaling [RGD, Feb 2006]
UniProt Comments for Card9
Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10.
Research Articles on Card9
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Products associated with Card9 recombinant protein
Pathways associated with Card9 recombinant protein
Diseases associated with Card9 recombinant protein
Organs/Tissues associated with Card9 recombinant protein
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