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COMT recombinant protein :: Catechol O-methyltransferase (COMT) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960242
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $620 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $765 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $830 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $915 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $920 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,030 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,150 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,165 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,290 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,665 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,755 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,765 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,220 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Catechol O-methyltransferase (COMT), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Catechol O-methyltransferase (COMT)

 Product Synonym Names    Catechol O-methyltransferase; EC=2.1.1.6
 Product Gene Name   

COMT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS960242 COA    COA PDF
 Sequence Positions    52-271aa; Partial
 Sequence    GDTKEQRILN HVLQHAEPGN AQSVLEAIDT YCEQKEWAMN VGDKKGKIVD AVIQEHQPSV LLELGAYCGY SAVRMARLLS PGARLITIEI NPDCAAITQR MVDFAGVKDK VTLVVGASQD IIPQLKKKYD VDTLDMVFLD HWKDRYLPDT LLLEECGLLR KGTVLLADNV ICPGAPDFLA HVRGSSCFEC THYQSFLEYR EVVDGLEKAI YKGPGSEAGP
 OMIM    116790
 3D Structure    ModBase 3D Structure for P21964
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of COMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for COMT recombinant protein

   Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
 Product Categories/Family for COMT recombinant protein    Metabolism
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 SDS-Page of COMT recombinant protein    COMT recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for COMT. It may not necessarily be applicable to this product.
 NCBI GI #    4502969
 NCBI GeneID    1312
 NCBI Accession #    NP_000745.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000754.3 [Other Products]
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 UniProt Primary Accession #    P21964 [Other Products]
 UniProt Secondary Accession #    Q6IB07; Q6ICE6; Q9BWC7; A8MPV9 [Other Products]
 UniProt Related Accession #    P21964 [Other Products]
 Molecular Weight    24,449 Da
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 NCBI Official Full Name    catechol O-methyltransferase isoform MB-COMT
 NCBI Official Synonym Full Names    catechol-O-methyltransferase
 NCBI Official Symbol    COMT [Similar Products]
 NCBI Official Synonym Symbols   
HEL-S-98n
[Similar Products]
 NCBI Protein Information    catechol O-methyltransferase; epididymis secretory sperm binding protein Li 98n
 UniProt Protein Name    Catechol O-methyltransferase
 Protein Family    Catechol O-methyltransferase
 UniProt Gene Name    COMT [Similar Products]
 UniProt Entry Name    COMT_HUMAN
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 NCBI Summary for COMT    Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
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 UniProt Comments for COMT    COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Methyltransferase; Amino Acid Metabolism - tyrosine; EC 2.1.1.6

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: postsynaptic membrane; mitochondrion; membrane; axon; integral to membrane; plasma membrane; dendritic spine; cytosol

Molecular Function: protein binding; magnesium ion binding; O-methyltransferase activity; catechol O-methyltransferase activity

Biological Process: response to drug; methylation; estrogen metabolic process; cellular response to phosphate starvation; neurotransmitter catabolic process; dopamine catabolic process; negative regulation of smooth muscle cell proliferation; short-term memory; response to pain; response to lipopolysaccharide; learning; female pregnancy; reproductive process in a multicellular organism; positive regulation of homocysteine metabolic process; response to organic cyclic substance; negative regulation of dopamine metabolic process; synaptic transmission; xenobiotic metabolic process; regulation of sensory perception of pain; developmental process; neurotransmitter biosynthetic process

Disease: Schizophrenia; Panic Disorder 1
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 Research Articles on COMT    1. the COMT rs4680 polymorphism is not a major determinant of either the risk for Parkinson's disease or clinical, neuropharmacological and neurochemical features [review and meta-analysis]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COMT recombinant proteinPathways associated with COMT recombinant protein
 Reference Product  PubMed Publications
 ACE recombinant protein  >11 publications with COMT and ACE
 Products by Pathway  Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Dopamine Clearance From The Synaptic Cleft Pathway antibodies  Dopamine Clearance From The Synaptic Cleft Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway antibodies  Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway Diagram
 Enzymatic Degradation Of Dopamine By COMT Pathway antibodies  Enzymatic Degradation Of Dopamine By COMT Pathway Diagram
 Estrogen Metabolism Pathway antibodies  Estrogen Metabolism Pathway Diagram
 L-dopa Degradation Pathway antibodies  L-dopa Degradation Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with COMT recombinant proteinOrgans/Tissues associated with COMT recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >892 publications with COMT and Mental Disorders
 Nervous System Diseases Antibodies  >579 publications with COMT and Nervous System Diseases
 Schizophrenia Antibodies  >444 publications with COMT and Schizophrenia
 Movement Disorders Antibodies  >374 publications with COMT and Movement Disorders
 Parkinson Disease Antibodies  >336 publications with COMT and Parkinson Disease
 Breast Neoplasms Antibodies  >146 publications with COMT and Breast Neoplasms
 Cognition Disorders Antibodies  >135 publications with COMT and Cognition Disorders
 Cardiovascular Diseases Antibodies  >133 publications with COMT and Cardiovascular Diseases
 Pain Antibodies  >132 publications with COMT and Pain
 Bipolar Disorder Antibodies  >114 publications with COMT and Bipolar Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >921 publications with COMT and Brain
 Blood Antibodies  >601 publications with COMT and Blood
 Liver Antibodies  >238 publications with COMT and Liver
 Nerve Antibodies  >134 publications with COMT and Nerve
 Muscle Antibodies  >131 publications with COMT and Muscle
 Heart Antibodies  >121 publications with COMT and Heart
 Vascular Antibodies  >116 publications with COMT and Vascular
 Kidney Antibodies  >94 publications with COMT and Kidney
 Lung Antibodies  >45 publications with COMT and Lung
 Adrenal Gland Antibodies  >39 publications with COMT and Adrenal Gland
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