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CTSB recombinant protein :: Cathepsin-B Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS146955 CTSB recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin-B (CTSB), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Cathepsin-B, Active

 Product Synonym Names    CTSB Mouse, Active; Cathepsin B; Cathepsin B1; CTSB; Cathepsin-B Mouse Recombinant, Active
 Product Gene Name   

CTSB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    HDKPSFHPLS DDLINYINKQ NTTWQAGRNF YNVDISYLKK LCGTVLGGPK LPGRVAFGED IDLPETFDAR EQWSNCPTIG QIRDQGSCGS CWAFGAVEAI SDRTCIHTNG RVNVEVSAED LLTCCGIQCG DGCNGGYPSG AWSFWTKKGL VSGGVYNSHV GCLPYTIPPC EHHVNGSRPP CTGEGDTPRC NKSCEAGYSP SYKEDKHFGY TSYSVSNSVK EIMAEIYKNG PVEGAFTVFS DFLTYKSGVY KHEAGDMMGG HAIRILGWGV ENGVPYWLAA NSWNLDWGDN GFFKILRGEN HCGIESEIVA GIPRTDQYWG RFLEHHH HHH
 3D Structure    ModBase 3D Structure for P10605
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Sterile filtered clear solution.
CTSB protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
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 Source    Sf9, Baculovirus cells
 Biological Activity    Specific activity is > 2, 000 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of Z-Arg-Arg-AMC to Z-Arg-Arg and AMC per minute at pH 6.0 at 37C.
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 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks.
Store, frozen at -20C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles
 Other Notes    Small volumes of CTSB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CTSB recombinant protein

   CTSB Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 330 amino acids (18-339a.a.) and having a molecular mass of 36.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). CTSB is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
 Product Categories/Family for CTSB recombinant protein    ENZYMES
NCBI/Uniprot data below describe general gene information for CTSB. It may not necessarily be applicable to this product.
 NCBI GI #    6681079
 NCBI GeneID    13030
 NCBI Accession #    NP_031824.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007798.3 [Other Products]
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 UniProt Primary Accession #    P10605 [Other Products]
 UniProt Secondary Accession #    Q3UDW7 [Other Products]
 UniProt Related Accession #    P10605 [Other Products]
 Molecular Weight    37,280 Da
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 NCBI Official Full Name    cathepsin B preproprotein
 NCBI Official Synonym Full Names    cathepsin B
 NCBI Official Symbol    Ctsb [Similar Products]
 NCBI Official Synonym Symbols   
CB
[Similar Products]
 NCBI Protein Information    cathepsin B
 UniProt Protein Name    Cathepsin B
 UniProt Synonym Protein Names   
Cathepsin B1
 Protein Family    Cathepsin
 UniProt Gene Name    Ctsb [Similar Products]
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 NCBI Summary for CTSB    This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
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 UniProt Comments for CTSB    CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.

Protein type: Autophagy; EC 3.4.22.1; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 14 D1|14 33.24 cM

Cellular Component: apical plasma membrane; caveola; cell surface; cytoplasm; external side of plasma membrane; extracellular region; extracellular space; intracellular membrane-bound organelle; lysosome; mitochondrion; nucleolus; perinuclear region of cytoplasm; sarcolemma

Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; kininogen binding; peptidase activity; peptide binding; protein complex binding; protein self-association; proteoglycan binding

Biological Process: collagen catabolic process; decidualization; entry of virus into host cell; proteolysis; proteolysis involved in cellular protein catabolic process
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 Research Articles on CTSB    1. CTSB in pancreatitis undergoes activation in a secretory, vesicular, and acidic compartment where it activates trypsinogen. Its deletion or inhibition regulates acinar cell apoptosis but not necrosis in two models of pancreatitis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTSB recombinant proteinPathways associated with CTSB recombinant protein
 Reference Product  PubMed Publications
 Ctsd recombinant protein  >43 publications with CTSB and Ctsd
 App recombinant protein  >8 publications with CTSB and App
 Mmp9 recombinant protein  >6 publications with CTSB and Mmp9
 Tlr9 recombinant protein  >2 publications with CTSB and Tlr9
 Cd74 recombinant protein  >1 publications with CTSB and Cd74
 Col18a1 recombinant protein  >1 publications with CTSB and Col18a1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with CTSB recombinant proteinOrgans/Tissues associated with CTSB recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >46 publications with CTSB and Inflammation
 Disease Models, Animal Antibodies  >37 publications with CTSB and Disease Models, Animal
 Nervous System Diseases Antibodies  >32 publications with CTSB and Nervous System Diseases
 Necrosis Antibodies  >31 publications with CTSB and Necrosis
 Brain Diseases Antibodies  >22 publications with CTSB and Brain Diseases
 Cardiovascular Diseases Antibodies  >22 publications with CTSB and Cardiovascular Diseases
 Liver Diseases Antibodies  >21 publications with CTSB and Liver Diseases
 Neoplasm Invasiveness Antibodies  >19 publications with CTSB and Neoplasm Invasiveness
 Disease Progression Antibodies  >17 publications with CTSB and Disease Progression
 Lung Neoplasms Antibodies  >16 publications with CTSB and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >65 publications with CTSB and Blood
 Liver Antibodies  >33 publications with CTSB and Liver
 Brain Antibodies  >33 publications with CTSB and Brain
 Lung Antibodies  >27 publications with CTSB and Lung
 Bone Antibodies  >18 publications with CTSB and Bone
 Muscle Antibodies  >17 publications with CTSB and Muscle
 Skin Antibodies  >14 publications with CTSB and Skin
 Pancreas Antibodies  >12 publications with CTSB and Pancreas
 Bone Marrow Antibodies  >12 publications with CTSB and Bone Marrow
 Heart Antibodies  >9 publications with CTSB and Heart
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