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CBX3 recombinant protein :: Chromobox Homolog 3 (CBX3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2012148 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $185 +1 FREE 8GB USB
0.05 mg  /  $385 +1 FREE 8GB USB
0.1 mg  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Chromobox Homolog 3 (CBX3), Recombinant Protein

 Also Known As   

Recombinant Chromobox Homolog 3 (CBX3)

 Product Gene Name   

CBX3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF- MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK WKGFTDADNT WEPEENLDCP ELIEDFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA ADKPRGFARG LDPERIIGAT DSSGELMFLM KWKDSDEADL VLAKEANMKC PQIVIAFYEE RLTWHSCPED EAQ
 Chromosome Location    Chromosome: 6; NC_000072.6 (51470616..51483704). Location: 6 B-C; 6 24.89 cM
 3D Structure    ModBase 3D Structure for P23198
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Mus musculus (Mouse)
 Expression System    Prokaryotic expression
 Residues    Met1~Gln183 (Accession # P23198) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of CBX3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CBX3 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for CBX3 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of CBX3 recombinant protein    CBX3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CBX3. It may not necessarily be applicable to this product.
 NCBI GI #    21903394
 NCBI GeneID    12417
 NCBI Accession #    P23198.2 [Other Products]
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 UniProt Primary Accession #    P23198 [Other Products]
 UniProt Secondary Accession #    Q921C4 [Other Products]
 UniProt Related Accession #    P23198 [Other Products]
 Molecular Weight    22.4kDa
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 NCBI Official Full Name    Chromobox protein homolog 3
 NCBI Official Synonym Full Names    chromobox 3
 NCBI Official Symbol    Cbx3 [Similar Products]
 NCBI Official Synonym Symbols   
M32; HP1g
[Similar Products]
 NCBI Protein Information    chromobox protein homolog 3; HP1 gamma; modifier 2 protein; chromobox homolog 3; heterochromatin protein 1 gamma; heterochromatin protein 1 homolog gamma
 UniProt Protein Name    Chromobox protein homolog 3
 UniProt Synonym Protein Names   
Heterochromatin protein 1 homolog gamma; HP1 gamma; M32; Modifier 2 protein
 Protein Family    Chromobox protein
 UniProt Gene Name    Cbx3 [Similar Products]
 UniProt Synonym Gene Names    HP1 gamma [Similar Products]
 UniProt Entry Name    CBX3_MOUSE
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 UniProt Comments for CBX3    CBX3: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1.

Protein type: DNA-binding

Cellular Component: nucleoplasm; nuclear envelope; spindle; nuclear heterochromatin; nucleus; chromatin; chromocenter

Molecular Function: protein domain specific binding; identical protein binding; protein binding; enzyme binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; rhythmic process; chromatin modification; negative regulation of transcription, DNA-dependent
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 Research Articles on CBX3    1. Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CBX3 recombinant proteinPathways associated with CBX3 recombinant protein
 Reference Product  PubMed Publications
 Trim28 recombinant protein  >2 publications with CBX3 and Trim28
 Kdm2b recombinant protein  >1 publications with CBX3 and Kdm2b
 Products by Pathway  Pathway Diagram
 Circadian Exercise Pathway antibodies  Circadian Exercise Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Polymerase I Chain Elongation Pathway antibodies  RNA Polymerase I Chain Elongation Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
Organs/Tissues associated with CBX3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with CBX3 and Blood
 Muscle Antibodies  >4 publications with CBX3 and Muscle
 Embryonic Tissue Antibodies  >4 publications with CBX3 and Embryonic Tissue
 Lung Antibodies  >2 publications with CBX3 and Lung
 Testis Antibodies  >2 publications with CBX3 and Testis
 Brain Antibodies  >2 publications with CBX3 and Brain
 Extraembryonic Tissue Antibodies  >1 publications with CBX3 and Extraembryonic Tissue
 Spleen Antibodies  >1 publications with CBX3 and Spleen
 Prostate Antibodies  >1 publications with CBX3 and Prostate
 Skin Antibodies  >1 publications with CBX3 and Skin
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