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mCNTF recombinant protein :: Ciliary Neurotrophic Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144453 mCNTF recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ciliary Neurotrophic Factor (mCNTF), Recombinant Protein

 Also Known As   

Recombinant Mouse Ciliary Neurotrophic Factor

 Product Synonym Names    CNTF Mouse; Ciliary-Neurotrophic Factor Mouse Recombinant; HCNTF; CNTF; Ciliary Neurotrophic Factor
 Product Gene Name   

mCNTF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLTLQVSAFA YQLEELMALL EQKVPEKEAD GMPVTIGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHHMGISAHE SHYGAKQM
 3D Structure    ModBase 3D Structure for P51642
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized CNTF in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of TF-1 cells is less than 35ng/ml, corresponding to a Specific Activity of 3.0x104 IU/mg.
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 Preparation and Storage    Lyophilized Ciliary Neurotrophic Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CNTF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of mCNTF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for mCNTF recombinant protein

   Description: Ciliary Neurotrophic Factor Recombinant Mouse produced in E Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.6kDa. The CNTF is purified by proprietary chromatographic techniques.

Introduction: CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
 Product Categories/Family for mCNTF recombinant protein    CYTOKINES AND GROWTH FACTORS; Neurotrophins; Ciliary-Neurotrophic Factor
NCBI/Uniprot data below describe general gene information for mCNTF. It may not necessarily be applicable to this product.
 NCBI GI #    25952141
 NCBI GeneID    12803
 NCBI Accession #    NP_740756.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170786.2 [Other Products]
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 UniProt Primary Accession #    P51642 [Other Products]
 UniProt Related Accession #    P51642 [Other Products]
 Molecular Weight    22,587 Da
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 NCBI Official Full Name    ciliary neurotrophic factor
 NCBI Official Synonym Full Names    ciliary neurotrophic factor
 NCBI Official Symbol    Cntf [Similar Products]
 NCBI Official Synonym Symbols   
AI429687
[Similar Products]
 NCBI Protein Information    ciliary neurotrophic factor
 UniProt Protein Name    Ciliary neurotrophic factor
 Protein Family    Ciliary neurotrophic factor
 UniProt Gene Name    Cntf [Similar Products]
 UniProt Synonym Gene Names    CNTF [Similar Products]
 UniProt Entry Name    CNTF_MOUSE
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 NCBI Summary for mCNTF    The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]
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 UniProt Comments for mCNTF    CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family.

Cellular Component: extracellular space; cell soma; axon; cytoplasm; nucleus; cytosol

Molecular Function: interleukin-6 receptor binding; growth factor activity; cytokine activity; ciliary neurotrophic factor receptor binding

Biological Process: negative regulation of photoreceptor cell differentiation; nervous system development; positive regulation of axon regeneration; protein heterooligomerization; multicellular organismal development; membrane hyperpolarization; positive regulation of hormone secretion; positive regulation of JAK-STAT cascade; JAK-STAT cascade; positive regulation of cell growth; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; regulation of resting membrane potential; regulation of retinal cell programmed cell death; neuron development; negative regulation of neuron apoptosis; astrocyte activation; cell differentiation; muscle morphogenesis; growth
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 Research Articles on mCNTF    1. STAT3 can activate CNTF transcription because it bound to its promoter and FAK antagonist-induced CNTF was reduced by blocking STAT3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mCNTF recombinant proteinPathways associated with mCNTF recombinant protein
 Reference Product  PubMed Publications
 Stat3 recombinant protein  >212 publications with mCNTF and Stat3
 Lifr recombinant protein  >129 publications with mCNTF and Lifr
 Gfap recombinant protein  >118 publications with mCNTF and Gfap
 Cntfr recombinant protein  >113 publications with mCNTF and Cntfr
 Il6st recombinant protein  >112 publications with mCNTF and Il6st
 Egf recombinant protein  >54 publications with mCNTF and Egf
 Socs3 recombinant protein  >31 publications with mCNTF and Socs3
 Apoe recombinant protein  >4 publications with mCNTF and Apoe
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with mCNTF recombinant proteinOrgans/Tissues associated with mCNTF recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >611 publications with mCNTF and Nervous System Diseases
 Brain Diseases Antibodies  >302 publications with mCNTF and Brain Diseases
 Disease Models, Animal Antibodies  >247 publications with mCNTF and Disease Models, Animal
 Nerve Degeneration Antibodies  >196 publications with mCNTF and Nerve Degeneration
 Inflammation Antibodies  >112 publications with mCNTF and Inflammation
 Necrosis Antibodies  >91 publications with mCNTF and Necrosis
 Peripheral Nervous System Diseases Antibodies  >81 publications with mCNTF and Peripheral Nervous System Diseases
 Weight Loss Antibodies  >73 publications with mCNTF and Weight Loss
 Atrophy Antibodies  >69 publications with mCNTF and Atrophy
 Movement Disorders Antibodies  >59 publications with mCNTF and Movement Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1302 publications with mCNTF and Brain
 Other Antibodies  >574 publications with mCNTF and Other
 Eye Antibodies  >401 publications with mCNTF and Eye
 Embryonic Tissue Antibodies  >334 publications with mCNTF and Embryonic Tissue
 Muscle Antibodies  >330 publications with mCNTF and Muscle
 Spinal Cord Antibodies  >283 publications with mCNTF and Spinal Cord
 Blood Antibodies  >206 publications with mCNTF and Blood
 Sympathetic Ganglion Antibodies  >118 publications with mCNTF and Sympathetic Ganglion
 Bone Antibodies  >111 publications with mCNTF and Bone
 Heart Antibodies  >65 publications with mCNTF and Heart
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