NP_001172001.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,110 Da
NCBI Official Full Name
claudin-12
NCBI Official Synonym Full Names
claudin 12
NCBI Protein Information
claudin-12
UniProt Protein Name
Claudin-12
NCBI Summary for CLDN12
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]
UniProt Comments for CLDN12
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Research Articles on CLDN12
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Pathways associated with CLDN12 recombinant protein
Diseases associated with CLDN12 recombinant protein
Organs/Tissues associated with CLDN12 recombinant protein
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