NP_038833.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,054 Da
NCBI Official Full Name
claudin-5
NCBI Official Synonym Full Names
claudin 5
NCBI Protein Information
claudin-5
UniProt Protein Name
Claudin-5
UniProt Synonym Protein Names
Brain endothelial cell clone 1 protein; Lung-specific membrane protein
UniProt Synonym Gene Names
UniProt Entry Name
CLD5_MOUSE
NCBI Summary for Cldn5
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010]
UniProt Comments for Cldn5
Claudin-5: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: apicolateral plasma membrane; cell junction; cortical actin cytoskeleton; integral to membrane; intercellular junction; membrane; paranode region of axon; plasma membrane; tight junction
Molecular Function: protein binding; structural molecule activity
Biological Process: cell-cell adhesion; intercellular junction assembly; myelination; transforming growth factor beta receptor signaling pathway
Research Articles on Cldn5
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Products associated with Cldn5 recombinant protein
Pathways associated with Cldn5 recombinant protein
Diseases associated with Cldn5 recombinant protein
Organs/Tissues associated with Cldn5 recombinant protein
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