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F7 recombinant protein :: Coagulation Factor VIIa Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142886 F7 recombinant protein
Unit / Price
0.01 mg  /  $205 +1 FREE 8GB USB
0.05 mg  /  $415 +1 FREE 8GB USB
1 mg  /  $3,075 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Coagulation Factor VIIa (F7), Recombinant Protein

 Also Known As   

Recombinant Human Coagulation Factor VIIa

 Product Synonym Names    F7 Human; Coagulation Factor VIIa Human Recombinant; Coagulation factor VII; EC 3.4.21.21; Serum prothrombin conversion accelerator; SPCA; Proconvertin; Eptacog alfa; F7
 Product Gene Name   

F7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    227500
 3D Structure    ModBase 3D Structure for P08709
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 Host    BHK cells (Baby Hamster Kidney Cells)
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 Purity/Purification    Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein 1 mg/ml was lyophilized after from a sterile solution containing 4.86 mg sodium chloride, 2.45 mg calcium chloride dihydrate, 50 mg mannitol and 116 ug Tween 80.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The potency per mg was tested and found to be 50,000Units/mg.
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 Preparation and Storage    Lyophilized Factor-VIIa although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Factor-VIIa should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of F7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for F7 recombinant protein

   Description: Factor VIIa Human Recombinant produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD.The Factor-VIIa is purified by proprietary chromatographic techniques.

Introduction: Coagulation factor VII is a vitamin K-dependent factor which is essential for hemostasis. It circulates in the blood as a zymogen which is later converted to an active form by factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of factor VII, a heavy chain with a catalytic domain and a light chain with 2 EGF-like domains are generated, and the two chains are held together by a disulfide bond. The presence of factor III and calcium ions further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of factor VII results in 2 transcripts. Defects in coagulation factor VII can cause coagulopathy. Coagulation factor VII initiates the extrinsic pathway of blood coagulation. Minor proteolysis converts factor VII to factor VIIa by factors Xa, XIIa, IXa, or thrombin. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium.
 Product Categories/Family for F7 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Coagulation Factors
NCBI/Uniprot data below describe general gene information for F7. It may not necessarily be applicable to this product.
 NCBI GI #    4503645
 NCBI GeneID    2155
 NCBI Accession #    NP_000122.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000131.4 [Other Products]
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 UniProt Primary Accession #    P08709 [Other Products]
 UniProt Secondary Accession #    Q14339; Q5JVF1; Q5JVF2; Q9UD52; Q9UD53; Q9UD54; B0YJC8 [Other Products]
 UniProt Related Accession #    P08709 [Other Products]
 Molecular Weight    49,320 Da
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 NCBI Official Full Name    coagulation factor VII isoform a preproprotein
 NCBI Official Synonym Full Names    coagulation factor VII (serum prothrombin conversion accelerator)
 NCBI Official Symbol    F7 [Similar Products]
 NCBI Official Synonym Symbols   
SPCA
[Similar Products]
 NCBI Protein Information    coagulation factor VII; FVII coagulation protein; eptacog alfa; proconvertin
 UniProt Protein Name    Coagulation factor VII
 UniProt Synonym Protein Names   
Proconvertin; Serum prothrombin conversion accelerator; SPCA; INN: Eptacog alfaCleaved into the following 2 chains:Factor VII light chain; Factor VII heavy chain
 Protein Family    Coagulation factor
 UniProt Gene Name    F7 [Similar Products]
 UniProt Synonym Gene Names    SPCA [Similar Products]
 UniProt Entry Name    FA7_HUMAN
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 NCBI Summary for F7    This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for F7    F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Apoptosis; Secreted; Protease; EC 3.4.21.21

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane; vesicle

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; glycoprotein binding; receptor binding

Biological Process: circadian rhythm; organ regeneration; positive regulation of positive chemotaxis; positive regulation of blood coagulation; positive regulation of leukocyte chemotaxis; proteolysis; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; response to vitamin K; response to estrogen stimulus; blood coagulation; positive regulation of cell migration

Disease: Myocardial Infarction, Susceptibility To; Factor Vii Deficiency
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 Research Articles on F7    1. Data indicate that the Eph tyrosine kinase receptors EphB2 and EphA2 are involved in factor/coagulation factor VIIa (TF/FVIIa) signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with F7 recombinant proteinPathways associated with F7 recombinant protein
 Reference Product  PubMed Publications
 F10 recombinant protein  >26 publications with F7 and F10
 APOB recombinant protein  >4 publications with F7 and APOB
 VWF recombinant protein  >4 publications with F7 and VWF
 GGCX recombinant protein  >4 publications with F7 and GGCX
 TFPI recombinant protein  >1 publications with F7 and TFPI
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway antibodies  Extrinsic Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
Diseases associated with F7 recombinant proteinOrgans/Tissues associated with F7 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >68 publications with F7 and Cardiovascular Diseases
 Factor VII Deficiency Antibodies  >42 publications with F7 and Factor VII Deficiency
 Hemorrhagic Disorders Antibodies  >40 publications with F7 and Hemorrhagic Disorders
 Heart Diseases Antibodies  >32 publications with F7 and Heart Diseases
 Thrombosis Antibodies  >21 publications with F7 and Thrombosis
 Coronary Disease Antibodies  >17 publications with F7 and Coronary Disease
 Hemorrhage Antibodies  >15 publications with F7 and Hemorrhage
 Stroke Antibodies  >15 publications with F7 and Stroke
 Disease Models, Animal Antibodies  >14 publications with F7 and Disease Models, Animal
 Hypertension Antibodies  >14 publications with F7 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >171 publications with F7 and Brain
 Liver Antibodies  >33 publications with F7 and Liver
 Testis Antibodies  >5 publications with F7 and Testis
 Mammary Gland Antibodies  >1 publications with F7 and Mammary Gland
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