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F12 recombinant protein :: Coagulation Factor XIIa Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS135876
Testing Data
Unit / Price
0.05 mg  /  $440 +1 FREE 8GB USB
0.1 mg  /  $625 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Coagulation Factor XIIa (F12), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Coagulation Factor XIIa

 Product Gene Name   

F12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_000079.6 (55417966..55426802, complement). Location: 13; 13 B2
 3D Structure    ModBase 3D Structure for Q80YC5
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 Host    Insect cell culture
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    0.4 mg/ml (lot specific)
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 Aliquot    1 x 0.1 mg
 Volume    0.25 ml
 Buffer    4 mM Sodium Acetate; 0.15 M NaCl; pH 5.3
 Extinction Coefficient    1.73
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 Preparation and Storage    Store at -70C.
Shelf Life: 3 years from delivery
Ships with Dry Ice.
 Other Notes    Small volumes of F12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for F12 recombinant protein

   Mouse Factor alpha-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system of blood coagulation. Recombinant insect cell derived mouse Factor alpha-XIIa is manufactured by autoactivation of recombinant mouse Factor XII with Dextran Sulfate and re-purifed to remove the activator. >95 percent activation is observed on SDS-PAGE. The protein purity is determined by SDS-PAGE and activity is determined via complementation in a APTT clotting assay using Factor XII immuno-deficient human plasma. Custom mutants of Factor XII are also available, please contact us for details.
 Product Categories/Family for F12 recombinant protein    Factor XII; Mouse Factor XIIa
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 Testing Data of F12 recombinant protein    F12 recombinant protein Testing Data image
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NCBI/Uniprot data below describe general gene information for F12. It may not necessarily be applicable to this product.
 NCBI GI #    171906584
 NCBI GeneID    58992
 NCBI Accession #    NP_067464.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021489.2 [Other Products]
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 UniProt Primary Accession #    Q80YC5 [Other Products]
 UniProt Secondary Accession #    O35727; Q6PER0 [Other Products]
 UniProt Related Accession #    Q80YC5 [Other Products]
 Molecular Weight    75,000 (Approximate)
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 NCBI Official Full Name    coagulation factor XII
 NCBI Official Synonym Full Names    coagulation factor XII (Hageman factor)
 NCBI Official Symbol    F12 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    coagulation factor XII; hageman factor
 UniProt Protein Name    Coagulation factor XII
 UniProt Synonym Protein Names   
Hageman factor
 Protein Family    Coagulation factor
 UniProt Gene Name    F12 [Similar Products]
 UniProt Synonym Gene Names    HAF [Similar Products]
 UniProt Entry Name    FA12_MOUSE
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 NCBI Summary for F12    This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]
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 UniProt Comments for F12    F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family.

Protein type: Protease; Secreted; Chaperone; EC; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity

Biological Process: response to misfolded protein; positive regulation of blood coagulation; proteolysis; protein autoprocessing; fibrinolysis; hemostasis; plasma kallikrein-kinin cascade; regulation of blood coagulation; positive regulation of fibrinolysis; zymogen activation; protein processing; blood coagulation; Factor XII activation
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 Research Articles on F12    1. Inhibiting factor XIIa with rHA-Infestin-4 may present a safe and effective treatment to decrease the morbidity of silent brain ischemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with F12 recombinant proteinDiseases associated with F12 recombinant protein
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >50 publications with F12 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >46 publications with F12 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >28 publications with F12 and Neoplasms, Experimental
 Necrosis Antibodies  >21 publications with F12 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >20 publications with F12 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >18 publications with F12 and Liver Neoplasms
 Liver Diseases Antibodies  >18 publications with F12 and Liver Diseases
 Fetal Death Antibodies  >16 publications with F12 and Fetal Death
 Fetal Diseases Antibodies  >16 publications with F12 and Fetal Diseases
 Gastrointestinal Diseases Antibodies  >15 publications with F12 and Gastrointestinal Diseases
Organs/Tissues associated with F12 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >76 publications with F12 and Embryonic Tissue
 Liver Antibodies  >62 publications with F12 and Liver
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