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CFL1 recombinant protein :: Cofilin 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203129
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cofilin 1 (CFL1), Recombinant Protein

 Also Known As   

Cofilin 1, 1-166aa, Human, His-tag, Recombinant, E Coli

 Product Synonym Names    CFL1; CFL; Cofilin 1; CFL1; CFL; 18 kDa phosphoprotein(p18) 18 kDa phosphoprotein; CFL 1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; P18.
 Product Gene Name   

CFL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    20mM Tris pH 8.0, 10% Glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
 Endotoxin    < 1.0 Eu per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CFL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CFL1 recombinant protein

   Cofilin is a family of actin-binding proteins which disassembles actin filaments. It is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. Recombinant human Cofilin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
 Product Categories/Family for CFL1 recombinant protein    Actin & Myosin Related
 Applications Tested/Suitable for CFL1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of CFL1 recombinant protein    CFL1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CFL1. It may not necessarily be applicable to this product.
 NCBI GI #    5031635
 NCBI GeneID    1072
 NCBI Accession #    NP_005498 [Other Products]
 NCBI GenBank Nucleotide #    NM_005507.2 [Other Products]
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 UniProt Secondary Accession #    Q53Y87; Q9UCA2; B3KUQ1 [Other Products]
 UniProt Related Accession #    P23528 [Other Products]
 Molecular Weight    20kDa (186aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    cofilin-1
 NCBI Official Synonym Full Names    cofilin 1 (non-muscle)
 NCBI Official Symbol    CFL1 [Similar Products]
 NCBI Official Synonym Symbols   
CFL; HEL-S-15
[Similar Products]
 NCBI Protein Information    cofilin-1; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15; p18
 UniProt Protein Name    Cofilin-1
 UniProt Synonym Protein Names   
18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform
 Protein Family    Cofilin
 UniProt Gene Name    CFL1 [Similar Products]
 UniProt Synonym Gene Names    CFL; p18 [Similar Products]
 UniProt Entry Name    COF1_HUMAN
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 NCBI Summary for CFL1    The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
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 UniProt Comments for CFL1    Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.

Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; nuclear matrix; membrane; cytoplasm; intercellular junction; nucleus; vesicle

Molecular Function: protein binding; actin binding

Biological Process: platelet activation; actin filament depolymerization; axon guidance; positive regulation of actin filament depolymerization; response to virus; cytoskeleton organization and biogenesis; negative regulation of cell size; response to amino acid stimulus; protein amino acid phosphorylation; Rho protein signal transduction; neural fold formation; platelet degranulation; cytokinesis after mitosis; establishment of cell polarity; protein import into nucleus; ephrin receptor signaling pathway; innate immune response; regulation of cell morphogenesis; blood coagulation; actin cytoskeleton organization and biogenesis; neural crest cell migration; negative regulation of apoptosis
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Product References and Citations for CFL1 recombinant protein

   Mannherz H.G., et al (2007). J. Mol. Biol. 366 (3)745-755.
Olsen J.V., et al (2006). Cell. 127(3)635-648
Yang N., et al (1998) Nature. 393(6687)809-812
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 Research Articles on CFL1    1. It provides a brief overview of the current knowledge about the central role of cofilin/actin rods formation, where its dysregulation and malfunction might be the trigger to neurodegeneration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CFL1 recombinant proteinPathways associated with CFL1 recombinant protein
 Reference Product  PubMed Publications
 LIMK1 recombinant protein  >17 publications with CFL1 and LIMK1
 SSH1 recombinant protein  >7 publications with CFL1 and SSH1
 PFN1 recombinant protein  >4 publications with CFL1 and PFN1
 ACTG1 recombinant protein  >2 publications with CFL1 and ACTG1
 ACTB recombinant protein  >2 publications with CFL1 and ACTB
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
Diseases associated with CFL1 recombinant proteinOrgans/Tissues associated with CFL1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >10 publications with CFL1 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >9 publications with CFL1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >7 publications with CFL1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >7 publications with CFL1 and Breast Neoplasms
 Inflammation Antibodies  >5 publications with CFL1 and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with CFL1 and Neoplasms, Experimental
 Neoplasm Invasiveness Antibodies  >3 publications with CFL1 and Neoplasm Invasiveness
 Cardiovascular Diseases Antibodies  >2 publications with CFL1 and Cardiovascular Diseases
 Memory Disorders Antibodies  >2 publications with CFL1 and Memory Disorders
 Kidney Diseases Antibodies  >1 publications with CFL1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with CFL1 and Brain
 Muscle Antibodies  >14 publications with CFL1 and Muscle
 Blood Antibodies  >12 publications with CFL1 and Blood
 Nerve Antibodies  >11 publications with CFL1 and Nerve
 Lung Antibodies  >9 publications with CFL1 and Lung
 Kidney Antibodies  >6 publications with CFL1 and Kidney
 Uterus Antibodies  >5 publications with CFL1 and Uterus
 Vascular Antibodies  >4 publications with CFL1 and Vascular
 Eye Antibodies  >3 publications with CFL1 and Eye
 Embryonic Tissue Antibodies  >3 publications with CFL1 and Embryonic Tissue
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