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CIRBP recombinant protein :: Cold Inducible RNA Binding Protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143788 CIRBP recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cold Inducible RNA Binding Protein (CIRBP), Recombinant Protein

 Also Known As   

Recombinant Human Cold Inducible RNA Binding Protein

 Product Synonym Names    CIRBP Human; Cold Inducible RNA Binding Protein Human Recombinant; Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP; CIRBP; A18HNRNP; CIRP
 Product Gene Name   

CIRBP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE
 OMIM    602649
 3D Structure    ModBase 3D Structure for Q14011
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    CIRBP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.1M NaCl.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of CIRBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CIRBP recombinant protein

   Description: CIRBP produced in E Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 20.8kDa.CIRBP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Cold inducible RNA-binding protein (CIRBP) has a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP localizes to the nucleus and contains one RRM (RNA recognition motif) domain. Expressed ubiquitously, CIRBP is believed to play a crucial role in the suppression of cellular proliferation in response to UV irradiation or extreme cold.
 Product Categories/Family for CIRBP recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for CIRBP. It may not necessarily be applicable to this product.
 NCBI GI #    4502847
 NCBI GeneID    1153
 NCBI Accession #    NP_001271.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001280.2 [Other Products]
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 UniProt Primary Accession #    Q14011 [Other Products]
 UniProt Secondary Accession #    B3KT17; B4E2X2 [Other Products]
 UniProt Related Accession #    Q14011 [Other Products]
 Molecular Weight    26,130 Da
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 NCBI Official Full Name    cold-inducible RNA-binding protein isoform 1
 NCBI Official Synonym Full Names    cold inducible RNA binding protein
 NCBI Official Symbol    CIRBP [Similar Products]
 NCBI Official Synonym Symbols   
CIRP
[Similar Products]
 NCBI Protein Information    cold-inducible RNA-binding protein; A18 hnRNP; cold inducible RNA-binding protein; glycine-rich RNA binding protein
 UniProt Protein Name    Cold-inducible RNA-binding protein
 UniProt Synonym Protein Names   
A18 hnRNP; Glycine-rich RNA-binding protein CIRP
 Protein Family    Cold-inducible RNA-binding protein
 UniProt Gene Name    CIRBP [Similar Products]
 UniProt Synonym Gene Names    A18HNRNP; CIRP [Similar Products]
 UniProt Entry Name    CIRBP_HUMAN
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 UniProt Comments for CIRBP    Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (). Promotes assembly of stress granules (SGs), when overexpressed.
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 Research Articles on CIRBP    1. Cirp promotes the development of intestinal inflammation and colorectal tumors through regulating apoptosis and production of TNFalpha and IL23 in inflammatory cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with CIRBP recombinant proteinOrgans/Tissues associated with CIRBP recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >8 publications with CIRBP and Necrosis
 Inflammation Antibodies  >8 publications with CIRBP and Inflammation
 Infertility, Male Antibodies  >4 publications with CIRBP and Infertility, Male
 Brain Diseases Antibodies  >3 publications with CIRBP and Brain Diseases
 Hemorrhage Antibodies  >3 publications with CIRBP and Hemorrhage
 Disease Models, Animal Antibodies  >3 publications with CIRBP and Disease Models, Animal
 Liver Neoplasms Antibodies  >2 publications with CIRBP and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with CIRBP and Liver Diseases
 Hyperplasia Antibodies  >1 publications with CIRBP and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with CIRBP and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with CIRBP and Brain
 Testis Antibodies  >8 publications with CIRBP and Testis
 Liver Antibodies  >7 publications with CIRBP and Liver
 Blood Antibodies  >5 publications with CIRBP and Blood
 Ovary Antibodies  >3 publications with CIRBP and Ovary
 Heart Antibodies  >3 publications with CIRBP and Heart
 Vascular Antibodies  >2 publications with CIRBP and Vascular
 Bone Antibodies  >1 publications with CIRBP and Bone
 Kidney Antibodies  >1 publications with CIRBP and Kidney
 Connective Tissue Antibodies  >1 publications with CIRBP and Connective Tissue
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