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COL2a1 recombinant protein :: Collagen Type II Alpha 1 (COL2a1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2012028 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $280 +1 FREE 8GB USB
0.1 mg  /  $440 +1 FREE 8GB USB
0.2 mg  /  $540 +1 FREE 8GB USB
0.5 mg  /  $1,040 +1 FREE 8GB USB
1 mg  /  $1,545 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type II Alpha 1 (COL2a1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Collagen Type II Alpha 1 (COL2a1)

 Product Gene Name   

COL2a1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF- GGKQ GDQGIPGEAG APGLVGPRGE RGFPGERGSP GAQGLQGPRG LPGTPGTDGP KGAAGPDGPP GAQGPPGLQG MPGERGAAGI AGPKGDRGDV GEKGPEGAPG KDGGRGLTGP IGPPGPAGAN GEKGEVGPPG PSGSTGA
 Chromosome Location    Chromosome: 15; NC_000081.6 (97975602..98004724, complement). Location: 15 F1; 15 53.97 cM
 3D Structure    ModBase 3D Structure for P28481
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Mus musculus (Mouse)
 Expression System    Prokaryotic expression
 Residues    Gly677~Ala817 (Accession # P28481) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of COL2a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for COL2a1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for COL2a1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of COL2a1 recombinant protein    COL2a1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for COL2a1. It may not necessarily be applicable to this product.
 NCBI GI #    169658375
 NCBI GeneID    12824
 NCBI Accession #    NP_001106987.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001113515.2 [Other Products]
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 UniProt Primary Accession #    P28481 [Other Products]
 UniProt Secondary Accession #    Q61428; Q62031; Q62032; Q62033; Q641K3; Q6LDB1; Q6LDI8; Q6LDI9; Q80VY3; Q80X38; Q8CEF7 [Other Products]
 UniProt Related Accession #    P28481 [Other Products]
 Molecular Weight    14.3kDa
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 NCBI Official Full Name    collagen alpha-1(II) chain isoform 2
 NCBI Official Synonym Full Names    collagen, type II, alpha 1
 NCBI Official Symbol    Col2a1 [Similar Products]
 NCBI Official Synonym Symbols   
Dmm; Lpk; Col2; Del1; Col2a; Col2a-1; M100856; Rgsc856
[Similar Products]
 NCBI Protein Information    collagen alpha-1(II) chain; collagen alpha-1(II) chain; chondrocalcin; alpha-1 type II collagen; disproportionate micromelia; procollagen, type II, alpha 1
 UniProt Protein Name    Collagen alpha-1(II) chain
 UniProt Synonym Protein Names   
Alpha-1 type II collagen
 UniProt Gene Name    Col2a1 [Similar Products]
 UniProt Entry Name    CO2A1_MOUSE
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 UniProt Comments for COL2a1    COL2A1: the alpha-1 chain of type II collagen, an extra-cellular matrix protein found in cartilage and the vitreous humor of the eye. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Chondrocalcin is the calcium binding C-propeptide of this collagen molecule. Defects in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. There are two transcripts identified for this gene. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; collagen; collagen type II; cytoplasm; extracellular region; basement membrane

Molecular Function: identical protein binding; platelet-derived growth factor binding; extracellular matrix structural constituent; metal ion binding

Biological Process: heart morphogenesis; proteoglycan metabolic process; inner ear morphogenesis; collagen fibril organization; palate development; limb morphogenesis; sensory perception of sound; visual perception; regulation of gene expression; skeletal morphogenesis; cartilage development; tissue homeostasis; chondrocyte differentiation; skeletal development; inner ear development; cartilage condensation; endochondral ossification
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 Research Articles on COL2a1    1. Type II collagen induces peripheral tolerance in BALB/c mice via the generation of CD8+ T regulatory cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with COL2a1 recombinant proteinDiseases associated with COL2a1 recombinant protein
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >206 publications with COL2a1 and Osteoarthritis
 Osteochondrodysplasias Antibodies  >135 publications with COL2a1 and Osteochondrodysplasias
 Retinal Detachment Antibodies  >50 publications with COL2a1 and Retinal Detachment
 Myopia Antibodies  >43 publications with COL2a1 and Myopia
 Cleft Palate Antibodies  >40 publications with COL2a1 and Cleft Palate
 Craniofacial Abnormalities Antibodies  >37 publications with COL2a1 and Craniofacial Abnormalities
 Neoplasms Antibodies  >28 publications with COL2a1 and Neoplasms
 Necrosis Antibodies  >27 publications with COL2a1 and Necrosis
 Kniest dysplasia Antibodies  >25 publications with COL2a1 and Kniest dysplasia
 Hearing Loss, Sensorineural Antibodies  >20 publications with COL2a1 and Hearing Loss, Sensorineural
Organs/Tissues associated with COL2a1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >391 publications with COL2a1 and Bone
 Joint Antibodies  >260 publications with COL2a1 and Joint
 Embryonic Tissue Antibodies  >90 publications with COL2a1 and Embryonic Tissue
 Eye Antibodies  >68 publications with COL2a1 and Eye
 Brain Antibodies  >17 publications with COL2a1 and Brain
 Kidney Antibodies  >14 publications with COL2a1 and Kidney
 Skin Antibodies  >13 publications with COL2a1 and Skin
 Heart Antibodies  >10 publications with COL2a1 and Heart
 Inner Ear Antibodies  >8 publications with COL2a1 and Inner Ear
 Uncharacterized Tissue Antibodies  >4 publications with COL2a1 and Uncharacterized Tissue
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