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Col4a1 recombinant protein :: Collagen alpha-1 (IV) chain (Col4a1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955657 Col4a1 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen alpha-1 (IV) chain (Col4a1), partial, Recombinant Protein

 Also Known As   

Recombinant Mouse Collagen alpha-1 (IV) chain (Col4a1), partial

 Product Synonym Names    Collagen alpha-1(IV) chainCleaved into the following chain:; 1. Arresten
 Product Gene Name   

Col4a1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P02463
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Col4a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Col4a1 recombinant protein

   Col4a1
NCBI/Uniprot data below describe general gene information for Col4a1. It may not necessarily be applicable to this product.
 NCBI GI #    161484654
 NCBI GeneID    12826
 NCBI Accession #    NP_034061.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009931.2 [Other Products]
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 UniProt Primary Accession #    P02463 [Other Products]
 UniProt Secondary Accession #    Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 [Other Products]
 UniProt Related Accession #    P02463 [Other Products]
 Molecular Weight    160,679 Da
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 NCBI Official Full Name    collagen alpha-1(IV) chain
 NCBI Official Synonym Full Names    collagen, type IV, alpha 1
 NCBI Official Symbol    Col4a1 [Similar Products]
 NCBI Official Synonym Symbols   
Bru; Raw; Svc; Col4a-1; Del(8)44H
[Similar Products]
 NCBI Protein Information    collagen alpha-1(IV) chain; collagen alpha-1(IV) chain; Del(8)Bru44H; alpha1(IV) collagen; retinal anterior wiring; procollagen, type IV, alpha 1
 UniProt Protein Name    Collagen alpha-1(IV) chain
 Protein Family    Collagen
 UniProt Gene Name    Col4a1 [Similar Products]
 UniProt Entry Name    CO4A1_MOUSE
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 UniProt Comments for Col4a1    COL4A1: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage (BSVDH). Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant. Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy aneurysms and muscle cramps (HANAC). The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex basement membrane defects in kidney and skin. The systemic angiopathy appears to affect both small vessels and large arteries. Defects in COL4A1 are a cause of familial porencephaly (POREN1). Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect or arrest in the development of the cerebral ventricles. Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen; collagen type IV; extracellular region; basement membrane

Molecular Function: extracellular matrix structural constituent; platelet-derived growth factor binding

Biological Process: patterning of blood vessels; blood vessel morphogenesis; brain development; angiogenesis; neuromuscular junction development
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 Research Articles on Col4a1    1. WT1 maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 and Col4a2 with SOX9.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Col4a1 recombinant proteinPathways associated with Col4a1 recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with Col4a1 and FLNA
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with Col4a1 recombinant proteinOrgans/Tissues associated with Col4a1 recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >24 publications with Col4a1 and Kidney Diseases
 Fibrosis Antibodies  >17 publications with Col4a1 and Fibrosis
 Disease Models, Animal Antibodies  >14 publications with Col4a1 and Disease Models, Animal
 Familial porencephaly Antibodies  >12 publications with Col4a1 and Familial porencephaly
 Inflammation Antibodies  >8 publications with Col4a1 and Inflammation
 Brain Small Vessel Disease with Hemorrhage Antibodies  >8 publications with Col4a1 and Brain Small Vessel Disease with Hemorrhage
 Hypertension Antibodies  >6 publications with Col4a1 and Hypertension
 Heart Diseases Antibodies  >6 publications with Col4a1 and Heart Diseases
 Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps Antibodies  >6 publications with Col4a1 and Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps
 Diabetic Nephropathies Antibodies  >6 publications with Col4a1 and Diabetic Nephropathies
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >31 publications with Col4a1 and Kidney
 Brain Antibodies  >25 publications with Col4a1 and Brain
 Eye Antibodies  >16 publications with Col4a1 and Eye
 Bone Antibodies  >8 publications with Col4a1 and Bone
 Skin Antibodies  >6 publications with Col4a1 and Skin
 Embryonic Tissue Antibodies  >5 publications with Col4a1 and Embryonic Tissue
 Inner Ear Antibodies  >4 publications with Col4a1 and Inner Ear
 Liver Antibodies  >3 publications with Col4a1 and Liver
 Joint Antibodies  >3 publications with Col4a1 and Joint
 Connective Tissue Antibodies  >3 publications with Col4a1 and Connective Tissue
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