Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Col11a1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PLA2G4B Antibody
 • ABCB8 cDNA Clone
 • H (+)-Cl (-) exchange transporter 7 (Clcn7) Recombinant Protein
 • COP9 signalosome complex subunit 2 (COPS2) Antibody
 • Thyroid Stimulating Hormone (TSH) ELISA Kit
 • Apolipoprotein A1 (Apo A1) ELISA Kit
 • PTPRS Antibody
 • Leukotriene E4 (LT-E4) ELISA Kit
 • MGLL Antibody
 • Bile salt export pump (ABCB11) ELISA Kit
 • 17-keto-steroid (17-KS) ELISA Kit
 • Adenylate kinase (adk) Recombinant Protein
 • Interferon alpha (IFN-alpha) ELISA Kit
 • cPLA2 ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Col11a1 recombinant protein :: Collagen alpha-1 (XI) chain (Col11a1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS959130 Col11a1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,220 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,220 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,490 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,490 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,945 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,945 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen alpha-1 (XI) chain (Col11a1), partial, Recombinant Protein

 Also Known As   

Recombinant Rat Collagen alpha-1 (XI) chain (Col11a1), partial

 Product Synonym Names    Collagen alpha-1(XI) chain
 Product Gene Name   

Col11a1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for P20909
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Rattus norvegicus (Rat)
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Col11a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for Col11a1 recombinant protein

   This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene.
NCBI/Uniprot data below describe general gene information for Col11a1. It may not necessarily be applicable to this product.
 NCBI GI #    402745263
 NCBI GeneID    25654
 NCBI Accession #    NP_037249.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013117.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P20909 [Other Products]
 UniProt Secondary Accession #    Q62750; Q63391; Q63392; Q63393; Q8VBY8; Q920Z7; Q920Z8; Q920Z9; Q921A0; Q921A1; F1LSI4 [Other Products]
 UniProt Related Accession #    P20909 [Other Products]
 Molecular Weight    166,848 Da
Table BarTOPTable Bar
 NCBI Official Full Name    collagen alpha-1(XI) chain
 NCBI Official Synonym Full Names    collagen, type XI, alpha 1
 NCBI Official Symbol    Col11a1 [Similar Products]
 NCBI Protein Information    collagen alpha-1(XI) chain; collagen alpha-1(XI) chain; collagen type XI; collagen type a1(XI)6B-7; collagen type a1(XI)6A-7-8; procollagen type XI alpha 1; procollagen, type XI, alpha 1
 UniProt Protein Name    Collagen alpha-1(XI) chain
 Protein Family    Collagen
 UniProt Gene Name    Col11a1 [Similar Products]
 UniProt Entry Name    COBA1_RAT
Section Bar
 NCBI Summary for Col11a1    subunit of heterotrimeric collagen XI molecule which is expressed in developing cartilage and plays a role in regulation of collagen fibril diameter size; alternatively spliced as six different isoforms; may be a substrate for BMP-1 [RGD, Feb 2006]
Section Bar
 UniProt Comments for Col11a1    COL11A1: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Defects in COL11A1 are the cause of Stickler syndrome type 2 (STL2); also known as Stickler syndrome vitreous type 2. STL2 is an autosomal dominant form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable. Defects in COL11A1 are the cause of Marshall syndrome (MRSHS). It is an autosomal dominant disorder characterized by ocular abnormalities, deafness, craniofacial anomalies, and anhidrotic ectodermal dysplasia. Clinical features include short stature; flat or retruded midface with short, depressed nose, flat nasal bridge and anteverted nares; cleft palate with or without the Pierre Robin sequence; appearance of large eyes with ocular hypertelorism; cataracts, either congenital or juvenile; esotropia; high myopia; sensorineural hearing loss; spondyloepiphyseal abnormalities; calcification of the falx cerebri; ectodermal abnormalities, including defects in sweating and dental structures. Defects in COL11A1 are the cause of fibrochondrogenesis type 1 (FBCG1). A severe short-limbed skeletal dysplasia characterized by broad long-bone metaphyses, pear-shaped vertebral bodies, and characteristic morphology of the growth plate, in which the chondrocytes have a fibroblastic appearance and there are regions of fibrous cartilage extracellular matrix. Clinical features include a flat midface with a small nose and anteverted nares, significant shortening of all limb segments but relatively normal hands and feet, and a small bell-shaped thorax with a protuberant abdomen. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Extracellular matrix

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen type XI; collagen

Molecular Function: metal ion binding; extracellular matrix structural constituent

Biological Process: heart morphogenesis; proteoglycan metabolic process; ossification; inner ear morphogenesis; collagen fibril organization; chondrocyte development; detection of mechanical stimulus involved in sensory perception of sound; embryonic skeletal morphogenesis; sensory perception of sound; visual perception; skeletal morphogenesis; cartilage development; ventricular cardiac muscle morphogenesis; cartilage condensation
Table BarTOPTable Bar
 Research Articles on Col11a1    1. two additional binding sites located within the noncollagenous amino-terminal domain may play a role in the function of collagen type XI
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with Col11a1 recombinant proteinPathways associated with Col11a1 recombinant protein
 Reference Product  PubMed Publications
 Col2a1 recombinant protein  >50 publications with Col11a1 and Col2a1
 Col1a1 recombinant protein  >17 publications with Col11a1 and Col1a1
 Col3a1 recombinant protein  >13 publications with Col11a1 and Col3a1
 Col5a1 recombinant protein  >11 publications with Col11a1 and Col5a1
 Col1a2 recombinant protein  >7 publications with Col11a1 and Col1a2
 Col12a1 recombinant protein  >4 publications with Col11a1 and Col12a1
 Col18a1 recombinant protein  >2 publications with Col11a1 and Col18a1
 Col5a3 recombinant protein  >1 publications with Col11a1 and Col5a3
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Cardiovascular Signaling Pathway antibodies  Cardiovascular Signaling Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with Col11a1 recombinant proteinOrgans/Tissues associated with Col11a1 recombinant protein
 Disease Name  Pubmed Publications
 Osteochondrodysplasias Antibodies  >13 publications with Col11a1 and Osteochondrodysplasias
 Marshall syndrome Antibodies  >13 publications with Col11a1 and Marshall syndrome
 Craniofacial Abnormalities Antibodies  >11 publications with Col11a1 and Craniofacial Abnormalities
 Inflammation Antibodies  >8 publications with Col11a1 and Inflammation
 Glaucoma, Angle-Closure Antibodies  >8 publications with Col11a1 and Glaucoma, Angle-Closure
 Intervertebral Disc Displacement Antibodies  >6 publications with Col11a1 and Intervertebral Disc Displacement
 Disease Models, Animal Antibodies  >4 publications with Col11a1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >4 publications with Col11a1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >4 publications with Col11a1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Col11a1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >30 publications with Col11a1 and Connective Tissue
 Eye Antibodies  >28 publications with Col11a1 and Eye
 Lung Antibodies  >6 publications with Col11a1 and Lung
 Brain Antibodies  >6 publications with Col11a1 and Brain
 Embryonic Tissue Antibodies  >6 publications with Col11a1 and Embryonic Tissue
 Inner Ear Antibodies  >3 publications with Col11a1 and Inner Ear
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions