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COL11A1 recombinant protein :: Collagen alpha-1(XI) chain Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS718449
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $135 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $180 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $255 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $490 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $665 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $715 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $910 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,135 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,170 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,790 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,790 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,615 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen alpha-1(XI) chain (COL11A1), Recombinant Protein

 Also Known As   

Recombinant Human Collagen alpha-1(XI) chain

 Product Gene Name   

COL11A1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS718449 COA    COA PDF
 Sequence Positions    532-699aa
 Sequence    GPMGLTGRPG PVGGPGSSGA KGESGDPGPQ GPRGVQGPPG PTGKPGKRGR PGADGGRGMP GEPGAKGDRG FDGLPGLPGD KGHRGERGPQ GPPGPPGDDG MRGEDGEIGP RGLPGEAGPR GLLGPRGTPG APGQPGMAGV DGPPGPKGNM GPQGEPGPPG QQGNPGPQ
 OMIM    120280
 3D Structure    ModBase 3D Structure for P12107
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of COL11A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for COL11A1 recombinant protein

   May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
 Product Categories/Family for COL11A1 recombinant protein    Signal Transduction
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 SDS-Page of COL11A1 recombinant protein    COL11A1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for COL11A1. It may not necessarily be applicable to this product.
 NCBI GI #    299523257
 NCBI GeneID    1301
 NCBI Accession #    NP_001177638.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190709.1 [Other Products]
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 UniProt Primary Accession #    P12107 [Other Products]
 UniProt Secondary Accession #    Q14034; Q149N0; Q9UIT4; Q9UIT5; Q9UIT6; B1ASK7; D3DT73; E9PCU0 [Other Products]
 UniProt Related Accession #    P12107 [Other Products]
 Molecular Weight    43.2kD
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 NCBI Official Full Name    collagen alpha-1(XI) chain isoform E preproprotein
 NCBI Official Synonym Full Names    collagen type XI alpha 1
 NCBI Official Symbol    COL11A1 [Similar Products]
 NCBI Official Synonym Symbols   
STL2; COLL6; CO11A1
[Similar Products]
 NCBI Protein Information    collagen alpha-1(XI) chain
 UniProt Protein Name    Collagen alpha-1(XI) chain
 Protein Family    Collagen
 UniProt Gene Name    COL11A1 [Similar Products]
 UniProt Synonym Gene Names    COLL6 [Similar Products]
 UniProt Entry Name    COBA1_HUMAN
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 NCBI Summary for COL11A1    This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
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 UniProt Comments for COL11A1    COL11A1: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Defects in COL11A1 are the cause of Stickler syndrome type 2 (STL2); also known as Stickler syndrome vitreous type 2. STL2 is an autosomal dominant form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable. Defects in COL11A1 are the cause of Marshall syndrome (MRSHS). It is an autosomal dominant disorder characterized by ocular abnormalities, deafness, craniofacial anomalies, and anhidrotic ectodermal dysplasia. Clinical features include short stature; flat or retruded midface with short, depressed nose, flat nasal bridge and anteverted nares; cleft palate with or without the Pierre Robin sequence; appearance of large eyes with ocular hypertelorism; cataracts, either congenital or juvenile; esotropia; high myopia; sensorineural hearing loss; spondyloepiphyseal abnormalities; calcification of the falx cerebri; ectodermal abnormalities, including defects in sweating and dental structures. Defects in COL11A1 are the cause of fibrochondrogenesis type 1 (FBCG1). A severe short-limbed skeletal dysplasia characterized by broad long-bone metaphyses, pear-shaped vertebral bodies, and characteristic morphology of the growth plate, in which the chondrocytes have a fibroblastic appearance and there are regions of fibrous cartilage extracellular matrix. Clinical features include a flat midface with a small nose and anteverted nares, significant shortening of all limb segments but relatively normal hands and feet, and a small bell-shaped thorax with a protuberant abdomen. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: collagen type XI; endoplasmic reticulum lumen; extracellular region

Molecular Function: extracellular matrix binding; extracellular matrix structural constituent; metal ion binding; protein binding, bridging

Biological Process: cartilage condensation; chondrocyte development; collagen catabolic process; collagen fibril organization; detection of mechanical stimulus involved in sensory perception of sound; embryonic skeletal morphogenesis; extracellular matrix disassembly; extracellular matrix organization and biogenesis; inner ear morphogenesis; ossification; proteoglycan metabolic process; sensory perception of sound; ventricular cardiac muscle morphogenesis; visual perception

Disease: Fibrochondrogenesis 1; Intervertebral Disc Disease; Marshall Syndrome; Stickler Syndrome, Type Ii
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Product References and Citations for COL11A1 recombinant protein

   Pro-alpha 1(XI) collagen. Structure of the amino-terminal propeptide and expression of the gene in tumor cell lines.Yoshioka H., Ramirez F.J. Biol. Chem. 265:6423-6426(1990) Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes.Annunen S., Koerkkoe J., Czarny M., Warman M.L., Brunner H.G., Kaeaeriaeinen H., Mulliken J.B., Tranebjaerg L., Brooks D.G., Cox G.F., Cruysberg J.R., Curtis M.A., Davenport S.L.H., Friedrich C.A., Kaitila I., Krawczynski M.R., Latos-Bielenska A., Mukai S., Olsen B.R., Shinno N., Somer M., Vikkula M., Zlotogora J., Prockop D.J., Ala-Kokko L.Am. J. Hum. Genet. 65:974-983(1999) The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006)
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 Research Articles on COL11A1    1. High Col11A1 mRNA expression is associated with Adenocarcinoma of the Papilla of Vater and Pancreas Carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COL11A1 recombinant proteinPathways associated with COL11A1 recombinant protein
 Reference Product  PubMed Publications
 COL2A1 recombinant protein  >54 publications with COL11A1 and COL2A1
 COL1A1 recombinant protein  >23 publications with COL11A1 and COL1A1
 COL9A2 recombinant protein  >18 publications with COL11A1 and COL9A2
 COL3A1 recombinant protein  >13 publications with COL11A1 and COL3A1
 COL5A2 recombinant protein  >9 publications with COL11A1 and COL5A2
 COL24A1 recombinant protein  >3 publications with COL11A1 and COL24A1
 LUM recombinant protein  >1 publications with COL11A1 and LUM
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with COL11A1 recombinant proteinOrgans/Tissues associated with COL11A1 recombinant protein
 Disease Name  Pubmed Publications
 Osteochondrodysplasias Antibodies  >17 publications with COL11A1 and Osteochondrodysplasias
 Marshall syndrome Antibodies  >14 publications with COL11A1 and Marshall syndrome
 Glaucoma, Angle-Closure Antibodies  >13 publications with COL11A1 and Glaucoma, Angle-Closure
 Craniofacial Abnormalities Antibodies  >13 publications with COL11A1 and Craniofacial Abnormalities
 Inflammation Antibodies  >10 publications with COL11A1 and Inflammation
 Breast Neoplasms Antibodies  >9 publications with COL11A1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >7 publications with COL11A1 and Lung Neoplasms
 Intervertebral Disc Displacement Antibodies  >6 publications with COL11A1 and Intervertebral Disc Displacement
 Disease Models, Animal Antibodies  >5 publications with COL11A1 and Disease Models, Animal
 Necrosis Antibodies  >3 publications with COL11A1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >36 publications with COL11A1 and Connective Tissue
 Bone Antibodies  >34 publications with COL11A1 and Bone
 Eye Antibodies  >29 publications with COL11A1 and Eye
 Brain Antibodies  >10 publications with COL11A1 and Brain
 Lung Antibodies  >10 publications with COL11A1 and Lung
 Embryonic Tissue Antibodies  >7 publications with COL11A1 and Embryonic Tissue
 Muscle Antibodies  >7 publications with COL11A1 and Muscle
 Mouth Antibodies  >5 publications with COL11A1 and Mouth
 Intestine Antibodies  >5 publications with COL11A1 and Intestine
 Ear Antibodies  >5 publications with COL11A1 and Ear
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