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COL12A1 recombinant protein :: Collagen alpha-1(XII) chain Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1420623
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen alpha-1(XII) chain (COL12A1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Collagen alpha-1(XII) chain

 Product Synonym Names    Homo sapiens (Human)
 Product Gene Name   

COL12A1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1420623 COA    COA PDF
 Sequence Positions    140-316aa; Partial
 Sequence    DLVFLVDGSW SVGRNNFKYI LDFIAALVSA FDIGEEKTRV GVVQYSSDTR TEFNLNQYYQ RDELLAAIKK IPYKGGNTMT GDAIDYLVKN TFTESAGARV GFPKVAIIIT DGKSQDEVEI PARELRNVGV EVFSLGIKAA DAKELKQIAS TPSLNHVFNV ANFDAIVDIQ NEIISQV
 OMIM    120320
 3D Structure    ModBase 3D Structure for Q99715
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of COL12A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for COL12A1 recombinant protein

   Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
 Product Categories/Family for COL12A1 recombinant protein    Signal Transduction
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 SDS-PAGE of COL12A1 recombinant protein    COL12A1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for COL12A1. It may not necessarily be applicable to this product.
 NCBI GI #    93141047
 NCBI GeneID    1303
 NCBI Accession #    NP_004361.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004370.5 [Other Products]
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 UniProt Primary Accession #    Q99715 [Other Products]
 UniProt Secondary Accession #    O43853; Q15955; Q5VYK1; Q5VYK2; Q71UR3; Q99716 [Other Products]
 UniProt Related Accession #    Q99715 [Other Products]
 Molecular Weight    23.61kD
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 NCBI Official Full Name    collagen alpha-1(XII) chain long isoform
 NCBI Official Synonym Full Names    collagen type XII alpha 1
 NCBI Official Symbol    COL12A1 [Similar Products]
 NCBI Official Synonym Symbols   
COL12A1L; BA209D8.1; DJ234P15.1
[Similar Products]
 NCBI Protein Information    collagen alpha-1(XII) chain
 UniProt Protein Name    Collagen alpha-1(XII) chain
 Protein Family    Collagen
 UniProt Gene Name    COL12A1 [Similar Products]
 UniProt Synonym Gene Names    COL12A1L [Similar Products]
 UniProt Entry Name    COCA1_HUMAN
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 NCBI Summary for COL12A1    This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for COL12A1    COL12A1: Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q12-q13

Cellular Component: collagen type XII; endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space

Molecular Function: extracellular matrix structural constituent conferring tensile strength

Biological Process: cell adhesion; collagen catabolic process; collagen fibril organization; extracellular matrix disassembly; extracellular matrix organization and biogenesis; skeletal development

Disease: Bethlem Myopathy 2; Ullrich Congenital Muscular Dystrophy 2
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Product References and Citations for COL12A1 recombinant protein

   "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13." Gerecke D.R., Olson P.F., Koch M., Knoll J.H.M., Taylor R., Hudson D.L., Champliaud M.-F., Olsen B.R., Burgeson R.E. Genomics 41:236-242(1997)
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 Research Articles on COL12A1    1. In conclusion, the novel main finding of this study was a significant interaction between the COL5A1 rs12722 T/C and COL12A1 rs970547 A/G variants and risk of anterior cruciate ligament injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COL12A1 recombinant proteinPathways associated with COL12A1 recombinant protein
 Reference Product  PubMed Publications
 COL1A1 recombinant protein  >12 publications with COL12A1 and COL1A1
 COL5A1 recombinant protein  >11 publications with COL12A1 and COL5A1
 COL3A1 recombinant protein  >10 publications with COL12A1 and COL3A1
 COL5A2 recombinant protein  >5 publications with COL12A1 and COL5A2
 COL1A2 recombinant protein  >4 publications with COL12A1 and COL1A2
 COL8A1 recombinant protein  >2 publications with COL12A1 and COL8A1
 COL5A3 recombinant protein  >1 publications with COL12A1 and COL5A3
 COL4A2 recombinant protein  >1 publications with COL12A1 and COL4A2
 COL15A1 recombinant protein  >1 publications with COL12A1 and COL15A1
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with COL12A1 recombinant proteinOrgans/Tissues associated with COL12A1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with COL12A1 and Nervous System Diseases
 Fibrosis Antibodies  >3 publications with COL12A1 and Fibrosis
 Breast Neoplasms Antibodies  >3 publications with COL12A1 and Breast Neoplasms
 Inflammation Antibodies  >3 publications with COL12A1 and Inflammation
 Heart Diseases Antibodies  >1 publications with COL12A1 and Heart Diseases
 Congenital Abnormalities Antibodies  >1 publications with COL12A1 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >1 publications with COL12A1 and Neoplasms, Experimental
 Hypertension Antibodies  >1 publications with COL12A1 and Hypertension
 Kidney Diseases Antibodies  >1 publications with COL12A1 and Kidney Diseases
 Hypertrophy Antibodies  >1 publications with COL12A1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with COL12A1 and Muscle
 Connective Tissue Antibodies  >11 publications with COL12A1 and Connective Tissue
 Bone Antibodies  >10 publications with COL12A1 and Bone
 Heart Antibodies  >3 publications with COL12A1 and Heart
 Kidney Antibodies  >3 publications with COL12A1 and Kidney
 Vascular Antibodies  >2 publications with COL12A1 and Vascular
 Intestine Antibodies  >2 publications with COL12A1 and Intestine
 Lung Antibodies  >2 publications with COL12A1 and Lung
 Embryonic Tissue Antibodies  >2 publications with COL12A1 and Embryonic Tissue
 Brain Antibodies  >1 publications with COL12A1 and Brain
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