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Col4a2 recombinant protein :: Collagen alpha-2 (IV) chain (Col4a2), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS962216
SDS-Page
Unit / Price
0.05 mg (Yeast)  /  $120 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $120 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen alpha-2 (IV) chain (Col4a2), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial

 Product Synonym Names    Collagen alpha-2(IV) chainCleaved into the following chain:; 1. Canstatin
 Product Gene Name   

Col4a2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1481-1707aa; Partial
 Sequence    VSIGYLLVKH SQTDQEPMCP VGMNKLWSGY SLLYFEGQEK AHNQDLGLAG SCLARFSTMP FLYCNPGDVC YYASRNDKSY WLSTTAPLPM MPVAEEEIKP YISRCSVCEA PAVAIAVHSQ DTSIPHCPAG WRSLWIGYSF LMHTAAGDEG GGQSLVSPGS CLEDFRATPF IECNGGRGTC HYFANKYSFW LTTIPEQNFQ STPSADTLKA GLIRTHISRC QVCMKNL
 3D Structure    ModBase 3D Structure for P08122
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Col4a2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Col4a2 recombinant protein

   Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins
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 SDS-Page of Col4a2 recombinant protein    Col4a2 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Col4a2. It may not necessarily be applicable to this product.
 NCBI GI #    226437587
 NCBI GeneID    12827
 NCBI Accession #    NP_034062.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_009932.3 [Other Products]
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 UniProt Primary Accession #    P08122 [Other Products]
 UniProt Secondary Accession #    Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 [Other Products]
 UniProt Related Accession #    P08122 [Other Products]
 Molecular Weight    167,325 Da
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 NCBI Official Full Name    collagen alpha-2(IV) chain preproprotein
 NCBI Official Synonym Full Names    collagen, type IV, alpha 2
 NCBI Official Symbol    Col4a2 [Similar Products]
 NCBI Official Synonym Symbols   
Col4a-2
[Similar Products]
 NCBI Protein Information    collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; canstatin; procollagen, type IV, alpha 2
 UniProt Protein Name    Collagen alpha-2(IV) chain
 Protein Family    Collagen
 UniProt Gene Name    Col4a2 [Similar Products]
 UniProt Entry Name    CO4A2_MOUSE
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 NCBI Summary for Col4a2    This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the collagen alpha-2(IV) chain and canstatin. The collagen chain is a subunit of heterotrimeric type IV collagen, which comprises a major structural component of basement membranes. Canstatin, which is cleaved from the C-terminus of the collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Aug 2015]
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 UniProt Comments for Col4a2    COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family.

Protein type: Secreted, signal peptide; Extracellular matrix; Secreted

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen; intracellular membrane-bound organelle; collagen type IV; extracellular region; basement membrane

Molecular Function: extracellular matrix structural constituent

Biological Process: negative regulation of angiogenesis; transcription, DNA-dependent; angiogenesis
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 Research Articles on Col4a2    1. WT1 maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 and Col4a2 with SOX9.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Col4a2 recombinant proteinDiseases associated with Col4a2 recombinant protein
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >12 publications with Col4a2 and Brain Diseases
 Kidney Diseases Antibodies  >10 publications with Col4a2 and Kidney Diseases
 Hemorrhage Antibodies  >9 publications with Col4a2 and Hemorrhage
 Fibrosis Antibodies  >7 publications with Col4a2 and Fibrosis
 Heart Diseases Antibodies  >4 publications with Col4a2 and Heart Diseases
 Lung Neoplasms Antibodies  >3 publications with Col4a2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with Col4a2 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >3 publications with Col4a2 and Liver Neoplasms
 Head and Neck Neoplasms Antibodies  >3 publications with Col4a2 and Head and Neck Neoplasms
 Liver Diseases Antibodies  >3 publications with Col4a2 and Liver Diseases
Organs/Tissues associated with Col4a2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >14 publications with Col4a2 and Kidney
 Brain Antibodies  >14 publications with Col4a2 and Brain
 Eye Antibodies  >8 publications with Col4a2 and Eye
 Embryonic Tissue Antibodies  >6 publications with Col4a2 and Embryonic Tissue
 Bone Antibodies  >5 publications with Col4a2 and Bone
 Liver Antibodies  >5 publications with Col4a2 and Liver
 Skin Antibodies  >5 publications with Col4a2 and Skin
 Lung Antibodies  >4 publications with Col4a2 and Lung
 Heart Antibodies  >3 publications with Col4a2 and Heart
 Stomach Antibodies  >3 publications with Col4a2 and Stomach
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