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COLEC11 recombinant protein :: Collectin 11 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS638161 COLEC11 recombinant protein
Unit / Price
0.05 mg  /  $710 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collectin 11 (COLEC11), Recombinant Protein

★Popular Item★
 Also Known As   

Collectin 11, Recombinant, Mouse (Collectin Kidney Protein 1, CL-K1, COLEC11)

 Product Gene Name   

COLEC11 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (3642422..3692234). Location: 2p25.3
 OMIM    265050
 3D Structure    ModBase 3D Structure for Q9BWP8
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 Purity/Purification    >85% as determined by SDS-PAGE under reducing conditions and visualized by silver strain.
 Form/Format    Supplied as a lyophilized powder from PBS. Reconstitute with sterile PBS to a concentration of 0.1mg/ml.
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 Activity    Measured by its ability to bind Alpha-L-Fucose.
 Endotoxin Level    <1EU per 1ug of protein (LAL)
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 Preparation and Storage    Lyophilized powder may be stored at -20C. Stable for 6 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of COLEC11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for COLEC11 recombinant protein

   Collectins constitute a family of C-type lectins that recognize molecular patterns expressed on pathogens. Members of this glycoprotein family contain a N-terminal domain, a collagen-like domain, a neck region, and a C-terminal carbohydrate recognition domain (CRD). Collectins are typically secreted molecules, although CL-P1 is membrane bound and CL-L1 is found in the cytoplasm (1-3). Collectin kidney 1 (CL-K1), also known as collectin subfamily member 11 (COLEC11), is a 37kD collectin that circulates in the serum (4, 5). It associates into disulfide-linked oligomers and preferentially interacts with fucose residues in a calcium-dependent manner (4). Mature mouse CL-K1 shares 94% and 98% amino acid sequence identity with human and rat CL-K1, respectively. Within the CRD, mouse CL-K1 shares 52% aa sequence identity with CL-L1 and 23%-32% aa sequence identity with collectins CL-P1, MBL, SP-A, and SP-D.

DNA sequence encoding mouse CL-K1 (Gln 27-Leu 272; Accession # AAI0438) was fused to a 6x polyhistidine tag at the C-terminus. The protein was expressed in a mouse myeloma cell line, NS0.
 Product Categories/Family for COLEC11 recombinant protein    Molecular Biology; MB-Binding Proteins
 Applications Tested/Suitable for COLEC11 recombinant protein   

Western Blot (WB)
Other applications not tested

 Application Notes for COLEC11 recombinant protein    Dilution: Western Blot: As a result of glycosylation the recombinant mouse CL-K1 migrates as an ~33-38kD protein in SDS-PAGE under reducing conditions.
Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for COLEC11. It may not necessarily be applicable to this product.
 NCBI GI #    13128972
 NCBI GeneID    78989
 NCBI Accession #    NP_076932.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_024027.4 [Other Products]
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 UniProt Primary Accession #    Q9BWP8 [Other Products]
 UniProt Secondary Accession #    Q5CZ85; A1IGE4; A1IGE5; A1IGE6; A7VJJ2; A7VJJ3; A7VJJ4; A7VJJ5; B2R9M5; B4E1G0; J3KQY9 [Other Products]
 UniProt Related Accession #    Q9BWP8 [Other Products]
 Molecular Weight    33-38kD [Similar Products]
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 NCBI Official Full Name    collectin-11 isoform a
 NCBI Official Synonym Full Names    collectin sub-family member 11
 NCBI Official Symbol    COLEC11 [Similar Products]
 NCBI Official Synonym Symbols   
3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb
[Similar Products]
 NCBI Protein Information    collectin-11; collectin kidney protein 1
 UniProt Protein Name    Collectin-11
 UniProt Synonym Protein Names   
Collectin kidney protein 1
 Protein Family    Collectin
 UniProt Gene Name    COLEC11 [Similar Products]
 UniProt Synonym Gene Names    CL-K1 [Similar Products]
 UniProt Entry Name    COL11_HUMAN
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 NCBI Summary for COLEC11    This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for COLEC11    COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: collagen; extracellular region

Molecular Function: mannose binding

Biological Process: receptor-mediated endocytosis; multicellular organismal development; developmental process

Disease: 3mc Syndrome 2
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 Research Articles on COLEC11    1. Data show that the concentration of collectin kidney 1 (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL) was 1.72 +/- 1.51 microg/ml.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with COLEC11 recombinant proteinDiseases associated with COLEC11 recombinant protein
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with COLEC11 and Inflammation
 Learning Disorders Antibodies  >1 publications with COLEC11 and Learning Disorders
 Liver Diseases Antibodies  >1 publications with COLEC11 and Liver Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with COLEC11 and Craniofacial Abnormalities
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