NP_034536.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
complement C5 preproprotein
NCBI Official Synonym Full Names
hemolytic complement
NCBI Official Synonym Symbols
NCBI Protein Information
complement C5
UniProt Protein Name
Complement C5
UniProt Synonym Protein Names
Hemolytic complementCleaved into the following 4 chains:Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain
UniProt Synonym Gene Names
UniProt Entry Name
CO5_MOUSE
UniProt Comments for mC5a
C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
Protein type: Secreted, signal peptide; Secreted
Cellular Component: membrane attack complex; extracellular space; extracellular region
Molecular Function: endopeptidase inhibitor activity
Biological Process: positive regulation of angiogenesis; in utero embryonic development; immune system process; cytolysis; complement activation, alternative pathway; innate immune response; inflammatory response; complement activation, classical pathway
Research Articles on mC5a
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Pathways associated with mC5a active protein
Diseases associated with mC5a active protein
Organs/Tissues associated with mC5a active protein
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