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CR1 recombinant protein :: Complement receptor type 1 (CR1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717740 CR1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $945 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $945 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,165 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,165 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,390 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,390 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,840 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,840 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement receptor type 1 (CR1), partial, Recombinant Protein

 Also Known As   

Recombinant Human Complement receptor type 1 (CR1), partial

 Product Synonym Names    Complement receptor type 1; C3b/C4b receptor; CD_antigen=; CD35
 Product Gene Name   

CR1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    CR1; C3BR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS717740 COA    COA PDF
 Sequence Positions    901-1095
 OMIM    611162
 3D Structure    ModBase 3D Structure for P17927
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CR1 recombinant protein

   CR1; C3BR
NCBI/Uniprot data below describe general gene information for CR1. It may not necessarily be applicable to this product.
 NCBI GI #    86793036
 NCBI GeneID    1378
 NCBI Accession #    NP_000564.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000573.3 [Other Products]
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 UniProt Primary Accession #    P17927 [Other Products]
 UniProt Secondary Accession #    Q16744; Q16745; Q5SR43; Q5SR45; Q9UQV2 [Other Products]
 UniProt Related Accession #    P17927 [Other Products]
 Molecular Weight    223,663 Da
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 NCBI Official Full Name    complement receptor type 1 isoform F
 NCBI Official Synonym Full Names    complement component (3b/4b) receptor 1 (Knops blood group)
 NCBI Official Symbol    CR1 [Similar Products]
 NCBI Official Synonym Symbols   
KN; C3BR; C4BR; CD35
[Similar Products]
 NCBI Protein Information    complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen
 UniProt Protein Name    Complement receptor type 1
 UniProt Synonym Protein Names   
C3b/C4b receptor; CD_antigen: CD35
 Protein Family    Complement receptor
 UniProt Gene Name    CR1 [Similar Products]
 UniProt Synonym Gene Names    C3BR [Similar Products]
 UniProt Entry Name    CR1_HUMAN
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 NCBI Summary for CR1    This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CR1    CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding

Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway

Disease: Knops Blood Group System; Malaria, Susceptibility To
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 Research Articles on CR1    1. CR1 rs7525160 G > C polymorphism was associated with an increased risk of developing non-small cell lung cancer in Chinese population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CR1 recombinant proteinPathways associated with CR1 recombinant protein
 Reference Product  PubMed Publications
 CR2 recombinant protein  >502 publications with CR1 and CR2
 CD55 recombinant protein  >101 publications with CR1 and CD55
 C4A recombinant protein  >13 publications with CR1 and C4A
 C1QA recombinant protein  >1 publications with CR1 and C1QA
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with CR1 recombinant proteinOrgans/Tissues associated with CR1 recombinant protein
 Disease Name  Pubmed Publications
 Malaria Antibodies  >49 publications with CR1 and Malaria
 Malaria, Falciparum Antibodies  >41 publications with CR1 and Malaria, Falciparum
 Alzheimer Disease Antibodies  >28 publications with CR1 and Alzheimer Disease
 Movement Disorders Antibodies  >2 publications with CR1 and Movement Disorders
 Nerve Degeneration Antibodies  >1 publications with CR1 and Nerve Degeneration
 Parkinsonian Disorders Antibodies  >1 publications with CR1 and Parkinsonian Disorders
 Anemia, Sideroblastic Antibodies  >1 publications with CR1 and Anemia, Sideroblastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1305 publications with CR1 and Blood
 Vascular Antibodies  >72 publications with CR1 and Vascular
 Lymph Node Antibodies  >43 publications with CR1 and Lymph Node
 Lymph Antibodies  >29 publications with CR1 and Lymph
 Nerve Antibodies  >22 publications with CR1 and Nerve
 Intestine Antibodies  >17 publications with CR1 and Intestine
 Connective Tissue Antibodies  >11 publications with CR1 and Connective Tissue
 Uterus Antibodies  >7 publications with CR1 and Uterus
 Mouth Antibodies  >4 publications with CR1 and Mouth
 Placenta Antibodies  >2 publications with CR1 and Placenta
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