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CTGF recombinant protein :: Connective Tissue Growth Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143709 CTGF recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,230 +6 FREE 8GB USB
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 Product Name   

Connective Tissue Growth Factor (CTGF), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Connective Tissue Growth Factor, HEK

 Product Synonym Names    CTGF Human, HEK; Connective Tissue Growth Factor Human Recombinant, HEK; CCN2; NOV2; HCS24; IGFBP8; MGC102839; CTGF; CTGF HEK
 Product Gene Name   

CTGF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    121009
 3D Structure    ModBase 3D Structure for P29279
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 Host    HEK293 Cells
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 Purity/Purification    Purity as determined by densitometric image analysis is greater than 90%.
 Form/Format    CTGF filtered (0.2 um) solution at a concentration of 0.22mg/ml in Citrate buffer pH 4.7 containing 20% (w/v) glycerol.
Filtered colorless solution.
 Concentration    0.22mg/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of CTGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CTGF purchase    Like all human growth factors, connective tissue growth factor CTGF - CCN family - is deeply involved in embryonic development, cell adhesion matrix formation and proliferation of cells during wound healing. To further understand the complex relationship of these biological processes, human CTGF and associated cytokines, MyBiosource offers an HEK expressed CTGF recombinant protein. Like all our mammalian expression recombinant proteins, CTGF human full length is amino acid sequence verified and activity determined dose dependent using vascular endothelial cells. Proliferation HUVEC cells assay is commonly used for other recombinant human cytokines growth factors chemokines cd, like insulin growth factor, neurotropic hormones enzymes in cell culture. This product is ideal to generate antibodies for pairing in lab made ELISAs and for many various human connective tissue binding experiments as have done in related products. Order recombinant human CTGF, catalog number MBS143709 for rapid shipping in United States and beyond.
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Related Product Information for CTGF recombinant protein

   Description: The CTGF Human Recombinant produced in HEK293 cells, is 36kDa protein containing a total of 329 amino acid residues (aa 27-349) including a C-terminal 6xHis tag.

Introduction: Connective Tissue Growth Factor belongs to the CCN family of proteins. The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane.CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. They are expressed in derivatives of the three embryonic sheets and are implicated in the development of kidney, nervous system, muscle, bone marrow, cartilage and bone. During adulthood, they are implicated in wound healing, bone fracture repair, and pathologies such as: fibrosis, vascular ailments and tumorigenesis.Full length secreted CCN proteins can show an antiproliferative activity, whereas truncated isoforms are likely to stimulate proliferation and behave as oncogenes.The full length protein consists of four modules: Module I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs).Module II includes a stretch of 70amino acid residues which shares sequence identity with the Von Willebrand Factor Type C repeat (VWC).Module III contains sequences sharing identity with the Thrombospondin type 1 repeat (TSP1) (WSXCSXXCG), which is thought to be implicated in the binding of sulfated glycoconjugates and to be important for cell adhesion.Module IV, also designated CT, is encoded by exon5. It is the leasts conserved one of the four domains at the level of nucleotide sequence, but it appears to be critical for several of the biological functions attributed to the CCN proteins. Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. Sequence similarities to heparin-binding motifs are also found within this domain.Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. Amino-truncated CCN2 isoforms were biologically active whereas no specific biological activity has been attributed to the truncated CCN3. Although the molecular processes underlying the production of these secreted isoforms is presently unknown, it is important to note that proteolysis occur at the same amino acid residues in both CCN2 and CCN3. An elevated expression of CCN2 has also been detected by Northern blotting in human invasive mammary ductal carcinomas, dermatofibromas, pyogenic granuloma, endothelial cells of angiolipomas and angioleiomyomas, and in pancreatic tumors. A study performed with chondrosarcomas representative of various histological grades established that CCN2 expression was closely correlated with increasing levels of malignancy.In agreement with CCN2 playing a role in brain tumor angiogenesis, immunocytochemistry studies indicated that both glioblastoma tumor cells and proliferating endothelial cells stained positive for CCN2. In astrocytomas, CCN2 expression was particularly elevated in high grade tumors, with a marked effect of CCN2 on cell proliferation. Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. Gene profiling analysis allowed to identify a set of about 50 genes whose expression might account for the proliferative activity of CCN2 in these cells.CCN2 was seen in a higher proportion of mononuclear cells of patients with acute lymphoblastic leukemia.
 Product Categories/Family for CTGF recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; CTGF
NCBI/Uniprot data below describe general gene information for CTGF. It may not necessarily be applicable to this product.
 NCBI GI #    4503123
 NCBI GeneID    1490
 NCBI Accession #    NP_001892.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001901.2 [Other Products]
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 UniProt Primary Accession #    P29279 [Other Products]
 UniProt Secondary Accession #    Q6LCY0; Q96A79; Q96QX2; Q9UDL6; E1P578 [Other Products]
 UniProt Related Accession #    P29279 [Other Products]
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 NCBI Official Full Name    connective tissue growth factor
 NCBI Official Synonym Full Names    connective tissue growth factor
 NCBI Official Symbol    CTGF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    connective tissue growth factor; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8
 UniProt Protein Name    Connective tissue growth factor
 UniProt Synonym Protein Names   
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
 Protein Family    Connective tissue growth factor
 UniProt Gene Name    CTGF [Similar Products]
 UniProt Synonym Gene Names    CCN2; HCS24; IGFBP8; IBP-8; IGF-binding protein 8; IGFBP-8 [Similar Products]
 UniProt Entry Name    CTGF_HUMAN
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 NCBI Summary for CTGF    The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CTGF    CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: Golgi apparatus; extracellular space; proteinaceous extracellular matrix; cis-Golgi network; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; extracellular region; cell cortex; cytosol

Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; protein binding; growth factor activity; fibronectin binding

Biological Process: response to peptide hormone stimulus; epidermis development; response to anoxia; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of caspase activity; cellular lipid metabolic process; response to estradiol stimulus; cell-cell signaling; positive regulation of cell proliferation; positive regulation of stress fiber formation; response to glucose stimulus; response to wounding; tissue homeostasis; regulation of cell growth; angiogenesis; cell differentiation; cell adhesion; cartilage condensation; positive regulation of cell activation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; cell migration; ossification; fibroblast growth factor receptor signaling pathway; organ senescence; response to mineralocorticoid stimulus; response to amino acid stimulus; gene expression; regulation of chondrocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of cell differentiation; lung development
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 Research Articles on CTGF    1. the SSc epidermis provides an important source of pro-fibrotic CCN2 and proinflammatory S100A9 in SSc skin, and therefore contributes to the fibrosis and inflammation seen in the disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTGF recombinant proteinPathways associated with CTGF recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >666 publications with CTGF and TGFB1
 SMAD7 recombinant protein  >57 publications with CTGF and SMAD7
 VEGFA recombinant protein  >24 publications with CTGF and VEGFA
 BMP7 recombinant protein  >18 publications with CTGF and BMP7
 BMP4 recombinant protein  >14 publications with CTGF and BMP4
 FN1 recombinant protein  >14 publications with CTGF and FN1
 TGFBR2 recombinant protein  >13 publications with CTGF and TGFBR2
 WWTR1 recombinant protein  >11 publications with CTGF and WWTR1
 TGFBI recombinant protein  >4 publications with CTGF and TGFBI
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Diseases associated with CTGF recombinant proteinOrgans/Tissues associated with CTGF recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1244 publications with CTGF and Fibrosis
 Disease Models, Animal Antibodies  >393 publications with CTGF and Disease Models, Animal
 Kidney Diseases Antibodies  >354 publications with CTGF and Kidney Diseases
 Cardiovascular Diseases Antibodies  >293 publications with CTGF and Cardiovascular Diseases
 Inflammation Antibodies  >286 publications with CTGF and Inflammation
 Lung Diseases Antibodies  >189 publications with CTGF and Lung Diseases
 Heart Diseases Antibodies  >180 publications with CTGF and Heart Diseases
 Liver Diseases Antibodies  >177 publications with CTGF and Liver Diseases
 Hypertension Antibodies  >159 publications with CTGF and Hypertension
 Carcinoma Antibodies  >154 publications with CTGF and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >2600 publications with CTGF and Connective Tissue
 Muscle Antibodies  >614 publications with CTGF and Muscle
 Kidney Antibodies  >598 publications with CTGF and Kidney
 Blood Antibodies  >494 publications with CTGF and Blood
 Vascular Antibodies  >453 publications with CTGF and Vascular
 Lung Antibodies  >294 publications with CTGF and Lung
 Bone Antibodies  >294 publications with CTGF and Bone
 Liver Antibodies  >287 publications with CTGF and Liver
 Heart Antibodies  >277 publications with CTGF and Heart
 Skin Antibodies  >222 publications with CTGF and Skin
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