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CX40 recombinant protein :: Connexin 40 (CX40) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010997 (3 units are in stock [0.1 mg] for immediate shipment)
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Connexin 40 (CX40), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Connexin 40 (CX40)

 Product Gene Name   

CX40 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_005101.3 (218648368..218669354). Location: 2q34
 3D Structure    ModBase 3D Structure for P28234
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 Host    E Coli
 Species Reactivity    Rat
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 Purity/Purification    >98%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
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 Source    Prokaryotic expression
 Original Concentration    200ug/mL
 Traits    Freeze-dried powder
 Residues    Ala50~Glu303
 Tags    N-terminal His-Tag
 Tissue Specificity    Lung
  Subcellular Location    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction
 Predicted isoelectric point    6.9
 Predicted Molecular Mass    30.1kDa
 Accurate Molecular Mass    20&16kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:
1. Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post-translational modification: Phosphorylation,glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for two years.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of CX40 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CX40 recombinant protein   

SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling

 Application Notes for CX40 recombinant protein    May be suitable for use in other assays to be determined by the end user.
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 Sequence of CX40 recombinant protein    CX40 recombinant protein Sequence image
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 Gene Sequence (extract) of CX40 recombinant protein    CX40 recombinant protein Gene Sequence (extract) image
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 SDS-PAGE of CX40 recombinant protein    CX40 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CX40. It may not necessarily be applicable to this product.
 NCBI GI #    9506725
 NCBI GeneID    50563
 NCBI Accession #    NP_062153.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019280.1 [Other Products]
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 UniProt Primary Accession #    P28234 [Other Products]
 UniProt Related Accession #    P28234 [Other Products]
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 NCBI Official Full Name    gap junction alpha-5 protein
 NCBI Official Synonym Full Names    gap junction protein, alpha 5
 NCBI Official Symbol    Gja5 [Similar Products]
 NCBI Official Synonym Symbols   
Cx40
[Similar Products]
 NCBI Protein Information    gap junction alpha-5 protein; connexin 40; connexin-40; gap junction membrane channel protein alpha 5
 UniProt Protein Name    Gap junction alpha-5 protein
 UniProt Synonym Protein Names   
Connexin-40
 UniProt Gene Name    Gja5 [Similar Products]
 UniProt Synonym Gene Names    Cxn-40; Cx40 [Similar Products]
 UniProt Entry Name    CXA5_RAT
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 NCBI Summary for CX40    forms intercellular connoxin channels in gap junctions; mediates cell-cell communication [RGD, Feb 2006]
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 UniProt Comments for CX40    GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily.

Protein type: Motility/polarity/chemotaxis; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: connexon complex; cell projection; integral to plasma membrane; gap junction

Molecular Function: gap junction hemi-channel activity; gap junction channel activity

Biological Process: blood vessel development; negative regulation of glomerular filtration; gap junction assembly; regulation of vasodilation; heart development; positive regulation of vasodilation; protein oligomerization; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure; regulation of systemic arterial blood pressure by renal system process; artery morphogenesis; embryonic heart tube development; negative regulation of blood pressure; angiogenesis; transmembrane transport; skeletal development; potassium ion transport; embryonic limb morphogenesis
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 Research Articles on CX40    1. Cx40 expression in mesangial cells is related to mesangial cell regeneration
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CX40 recombinant proteinPathways associated with CX40 recombinant protein
 Reference Product  PubMed Publications
 Tbx5 recombinant protein  >2 publications with CX40 and Tbx5
 Gata4 recombinant protein  >2 publications with CX40 and Gata4
 Gja1 recombinant protein  >2 publications with CX40 and Gja1
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
Diseases associated with CX40 recombinant proteinOrgans/Tissues associated with CX40 recombinant protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >16 publications with CX40 and Heart Diseases
 Atrial Fibrillation Antibodies  >12 publications with CX40 and Atrial Fibrillation
 Arrhythmias, Cardiac Antibodies  >12 publications with CX40 and Arrhythmias, Cardiac
 Cerebral Infarction Antibodies  >1 publications with CX40 and Cerebral Infarction
 Neoplasms Antibodies  >1 publications with CX40 and Neoplasms
 Cardiomyopathies Antibodies  >1 publications with CX40 and Cardiomyopathies
 Hypertrophy Antibodies  >1 publications with CX40 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >17 publications with CX40 and Heart
 Lung Antibodies  >3 publications with CX40 and Lung
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