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CKM recombinant protein :: Creatine Kinase Muscle Type-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142067 CKM recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $980 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Creatine Kinase Muscle Type-1 (CKM), Recombinant Protein

 Also Known As   

Recombinant Human Creatine Kinase Muscle Type-1

 Product Synonym Names    CKMT1 Human; Creatine Kinase Muscle Type-1 Human Recombinant; Creatine kinase M-type; EC 2.7.3.2; Creatine kinase M chain; M-CK; CKM; CKMM; CKMMITI; CKM Type-1
 Product Gene Name   

CKM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123310
 3D Structure    ModBase 3D Structure for P06732
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 Host    Pichia Pastoris
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 Purity/Purification    Greater than 95.0% as determined by a) Analysis by RP-HPLC b) Analysis by SDS-PAGE
 Form/Format    CKMT1 contains 0.01M Tris-HCl, 0.075M NaCl, 10mM beta-mercaptoethanol, 50% glycerol, 0.1% sodium azide, pH 7.2.
Sterile Filtered colourless liquid formulation.
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 Biological Activity    The biological activity measured by the enzymatic activity of Creatine phosphokinase procedure No.45-UV, 1IU-1 umole creatine phosphate was 537IU/mg at 37 degrees celsius corresponding to a Specific Activity of 1,863ng/ml.
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 Preparation and Storage    CKMT1 although stable at 15 degree C for 7 days, should be stored below -18 degree C. Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of CKM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CKM recombinant protein

   Description: CKMT1 Human Recombinant without C-terminal Lysine on both chains produced in Pichia Pastoris is a glycosylated 47kDa polypeptide chain having an identical amino acid sequence compared to the native enzyme, purified under non-denaturing conditions and reacts with polyclonal antibodies to MM Isoenzyme in ELISA. The CKMT1 is purified by proprietary chromatographic techniques.

Introduction: Creatine Kinase MM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.
 Product Categories/Family for CKM recombinant protein    PROTEIN KINASES; Enzymes; Creatin Kinases
NCBI/Uniprot data below describe general gene information for CKM. It may not necessarily be applicable to this product.
 NCBI GI #    21536288
 NCBI GeneID    1158
 NCBI Accession #    NP_001815.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001824.4 [Other Products]
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 UniProt Primary Accession #    P06732 [Other Products]
 UniProt Secondary Accession #    Q96QL9 [Other Products]
 UniProt Related Accession #    P06732 [Other Products]
 Molecular Weight    43,101 Da
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 NCBI Official Full Name    creatine kinase M-type
 NCBI Official Synonym Full Names    creatine kinase, muscle
 NCBI Official Symbol    CKM [Similar Products]
 NCBI Official Synonym Symbols   
CKMM; M-CK
[Similar Products]
 NCBI Protein Information    creatine kinase M-type; creatine kinase M chain
 UniProt Protein Name    Creatine kinase M-type
 UniProt Synonym Protein Names   
Creatine kinase M chain; M-CKCreatine kinase M-type, N-terminally processed
 Protein Family    Creatine kinase
 UniProt Gene Name    CKM [Similar Products]
 UniProt Synonym Gene Names    CKMM [Similar Products]
 UniProt Entry Name    KCRM_HUMAN
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 NCBI Summary for CKM    The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CKM    CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; ATP binding

Biological Process: phosphocreatine biosynthetic process; creatine metabolic process; phosphorylation
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 Research Articles on CKM    1. Estimation of CK and its CK isoenzyme fractions can aid in quick and accurate diagnosis of tubal ectopic pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CKM recombinant proteinPathways associated with CKM recombinant protein
 Reference Product  PubMed Publications
 CKB recombinant protein  >15 publications with CKM and CKB
 ATP2A1 recombinant protein  >2 publications with CKM and ATP2A1
 TNNC2 recombinant protein  >2 publications with CKM and TNNC2
 AK1 recombinant protein  >1 publications with CKM and AK1
 MYLPF recombinant protein  >1 publications with CKM and MYLPF
 GAMT recombinant protein  >1 publications with CKM and GAMT
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Creatine Metabolism Pathway antibodies  Creatine Metabolism Pathway Diagram
 Creatine Pathway antibodies  Creatine Pathway Diagram
 Creatine Pathway antibodies  Creatine Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Urea Cycle And Metabolism Of Amino Groups Pathway antibodies  Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
Diseases associated with CKM recombinant proteinOrgans/Tissues associated with CKM recombinant protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >12 publications with CKM and Heart Diseases
 Myocardial Infarction Antibodies  >7 publications with CKM and Myocardial Infarction
 Disease Models, Animal Antibodies  >6 publications with CKM and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with CKM and Kidney Diseases
 Lung Neoplasms Antibodies  >4 publications with CKM and Lung Neoplasms
 Ischemia Antibodies  >4 publications with CKM and Ischemia
 Liver Neoplasms Antibodies  >4 publications with CKM and Liver Neoplasms
 Weight Loss Antibodies  >3 publications with CKM and Weight Loss
 Inflammation Antibodies  >3 publications with CKM and Inflammation
 Liver Diseases Antibodies  >3 publications with CKM and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >56 publications with CKM and Muscle
 Heart Antibodies  >27 publications with CKM and Heart
 Kidney Antibodies  >10 publications with CKM and Kidney
 Brain Antibodies  >9 publications with CKM and Brain
 Liver Antibodies  >7 publications with CKM and Liver
 Lung Antibodies  >6 publications with CKM and Lung
 Embryonic Tissue Antibodies  >4 publications with CKM and Embryonic Tissue
 Vascular Antibodies  >4 publications with CKM and Vascular
 Bone Antibodies  >3 publications with CKM and Bone
 Nerve Antibodies  >2 publications with CKM and Nerve
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