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Cry1 recombinant protein :: Cryptochrome-1 (Cry1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958179 Cry1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,400 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,400 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,625 +2 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,625 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,360 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,360 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,800 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,800 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cryptochrome-1 (Cry1), Recombinant Protein

 Also Known As   

Recombinant Mouse Cryptochrome-1 (Cry1)

 Product Synonym Names    Cryptochrome-1
 Product Gene Name   

Cry1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-606
 Sequence    MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLVSKM EPLEMPADTI TSDVIGKCMT PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN IERMKQIYQQ LSRYRGLGLL ASVPSNSNGN GGLMGYAPGE NVPSCSSSGN GGLMGYAPGE NVPSCSGGNC SQGSGILHYA HGDSQQTHSL KQGRSSAGTG LSSGKRPSQE EDAQSVGPKV QRQSSN
 3D Structure    ModBase 3D Structure for P97784
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cry1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Cry1. It may not necessarily be applicable to this product.
 NCBI GI #    6681031
 NCBI GeneID    12952
 NCBI Accession #    NP_031797.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007771.3 [Other Products]
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 UniProt Primary Accession #    P97784 [Other Products]
 UniProt Related Accession #    P97784 [Other Products]
 Molecular Weight    68,001 Da
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 NCBI Official Full Name    cryptochrome-1
 NCBI Official Synonym Full Names    cryptochrome 1 (photolyase-like)
 NCBI Official Symbol    Cry1 [Similar Products]
 NCBI Official Synonym Symbols   
Phll1; AU020726; AU021000
[Similar Products]
 NCBI Protein Information    cryptochrome-1
 UniProt Protein Name    Cryptochrome-1
 Protein Family    Cryptochrome
 UniProt Gene Name    Cry1 [Similar Products]
 UniProt Entry Name    CRY1_MOUSE
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 NCBI Summary for Cry1    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]
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 UniProt Comments for Cry1    CRY1: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Binds MAPK. Interacts with FBXL21. Interacts with FBXL3. Expression is regulated by light and circadian rhythms. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL-CLOCK inhibition as part of the autoregulatory feedback loop. Belongs to the DNA photolyase class-1 family.

Protein type: DNA-binding; Transcription, coactivator/corepressor; Lyase

Cellular Component: mitochondrion; cytoplasm; nucleus

Molecular Function: DNA photolyase activity; protein binding; ubiquitin binding; histone deacetylase binding; double-stranded DNA binding; nucleotide binding; photoreceptor activity; kinase binding; protein kinase binding; transcription factor binding; phosphatase binding; nuclear hormone receptor binding

Biological Process: circadian rhythm; response to glucagon stimulus; transcription, DNA-dependent; DNA damage induced protein phosphorylation; negative regulation of G-protein coupled receptor protein signaling pathway; response to stimulus; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; DNA repair; glucose homeostasis; regulation of circadian rhythm; protein-chromophore linkage; entrainment of circadian clock by photoperiod; response to insulin stimulus; gluconeogenesis; sequestering of lipid; regulation of transcription, DNA-dependent; negative regulation of circadian rhythm; negative regulation of protein ubiquitination; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent
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 Research Articles on Cry1    1. Study determined the crystal structure of a complex comprising the photolyase homology region of mouse CRY1 (mCRY1) and a C-terminal mouse PER2 (mPER2) fragment and provides evidence that mCRY1/mPER2 complex formation is modulated by an interplay of zinc binding and mCRY1 disulfide bond formation, which may be influenced by the redox state of the cell.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cry1 recombinant proteinPathways associated with Cry1 recombinant protein
 Reference Product  PubMed Publications
 Clock recombinant protein  >452 publications with Cry1 and Clock
 Cry2 recombinant protein  >368 publications with Cry1 and Cry2
 Per2 recombinant protein  >252 publications with Cry1 and Per2
 Per1 recombinant protein  >236 publications with Cry1 and Per1
 Arntl recombinant protein  >125 publications with Cry1 and Arntl
 Per3 recombinant protein  >72 publications with Cry1 and Per3
 Npas2 recombinant protein  >38 publications with Cry1 and Npas2
 Fbxl3 recombinant protein  >13 publications with Cry1 and Fbxl3
 Csnk1e recombinant protein  >7 publications with Cry1 and Csnk1e
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Exercise Pathway antibodies  Circadian Exercise Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Mus Musculus Biological Processes Pathway antibodies  Mus Musculus Biological Processes Pathway Diagram
Diseases associated with Cry1 recombinant proteinOrgans/Tissues associated with Cry1 recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >22 publications with Cry1 and Mental Disorders
 Disease Models, Animal Antibodies  >16 publications with Cry1 and Disease Models, Animal
 Brain Diseases Antibodies  >13 publications with Cry1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >13 publications with Cry1 and Cardiovascular Diseases
 Necrosis Antibodies  >11 publications with Cry1 and Necrosis
 Inflammation Antibodies  >10 publications with Cry1 and Inflammation
 Breast Neoplasms Antibodies  >9 publications with Cry1 and Breast Neoplasms
 Fatty Liver Antibodies  >6 publications with Cry1 and Fatty Liver
 Hypertension Antibodies  >6 publications with Cry1 and Hypertension
 Adenocarcinoma Antibodies  >5 publications with Cry1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >191 publications with Cry1 and Eye
 Brain Antibodies  >123 publications with Cry1 and Brain
 Liver Antibodies  >58 publications with Cry1 and Liver
 Kidney Antibodies  >11 publications with Cry1 and Kidney
 Embryonic Tissue Antibodies  >10 publications with Cry1 and Embryonic Tissue
 Lung Antibodies  >6 publications with Cry1 and Lung
 Bone Antibodies  >5 publications with Cry1 and Bone
 Skin Antibodies  >3 publications with Cry1 and Skin
 Testis Antibodies  >3 publications with Cry1 and Testis
 Ovary Antibodies  >2 publications with Cry1 and Ovary
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