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Cry1 recombinant protein :: Cryptochrome-1 (Cry1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958179 Cry1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,030 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,210 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,390 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,475 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,530 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,535 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,665 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,180 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,195 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,200 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,520 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,880 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cryptochrome-1 (Cry1), Recombinant Protein

 Also Known As   

Recombinant Mouse Cryptochrome-1 (Cry1)

 Product Gene Name   

Cry1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-606aa, Full length protein
 Sequence    MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLVSKM EPLEMPADTI TSDVIGKCMT PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN IERMKQIYQQ LSRYRGLGLL ASVPSNSNGN GGLMGYAPGE NVPSCSSSGN GGLMGYAPGE NVPSCSGGNC SQGSGILHYA HGDSQQTHSL KQGRSSAGTG LSSGKRPSQE EDAQSVGPKV QRQSSN
 3D Structure    ModBase 3D Structure for P97784
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cry1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Cry1. It may not necessarily be applicable to this product.
 NCBI GI #    6681031
 NCBI GeneID    12952
 NCBI Accession #    NP_031797.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007771.3 [Other Products]
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 UniProt Primary Accession #    P97784 [Other Products]
 UniProt Related Accession #    P97784 [Other Products]
 Molecular Weight    68,001 Da
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 NCBI Official Full Name    cryptochrome-1
 NCBI Official Synonym Full Names    cryptochrome 1 (photolyase-like)
 NCBI Official Symbol    Cry1 [Similar Products]
 NCBI Official Synonym Symbols   
Phll1; AU020726; AU021000
[Similar Products]
 NCBI Protein Information    cryptochrome-1
 UniProt Protein Name    Cryptochrome-1
 Protein Family    Cryptochrome
 UniProt Gene Name    Cry1 [Similar Products]
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 NCBI Summary for Cry1    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]
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 UniProt Comments for Cry1    Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found atCLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1, ATF4, MTA1, KLF10 and NAMPT. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.
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 Research Articles on Cry1    1. Knockout-rescue embryonic stem cell-derived mouse reveals that CRY1 determines circadian period through both its degradation-dependent and -independent pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cry1 recombinant proteinPathways associated with Cry1 recombinant protein
 Reference Product  PubMed Publications
 Clock recombinant protein  >452 publications with Cry1 and Clock
 Cry2 recombinant protein  >368 publications with Cry1 and Cry2
 Per2 recombinant protein  >252 publications with Cry1 and Per2
 Per1 recombinant protein  >236 publications with Cry1 and Per1
 Arntl recombinant protein  >125 publications with Cry1 and Arntl
 Per3 recombinant protein  >72 publications with Cry1 and Per3
 Npas2 recombinant protein  >38 publications with Cry1 and Npas2
 Fbxl3 recombinant protein  >13 publications with Cry1 and Fbxl3
 Csnk1e recombinant protein  >7 publications with Cry1 and Csnk1e
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Exercise Pathway antibodies  Circadian Exercise Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Mus Musculus Biological Processes Pathway antibodies  Mus Musculus Biological Processes Pathway Diagram
Diseases associated with Cry1 recombinant proteinOrgans/Tissues associated with Cry1 recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >22 publications with Cry1 and Mental Disorders
 Disease Models, Animal Antibodies  >16 publications with Cry1 and Disease Models, Animal
 Brain Diseases Antibodies  >13 publications with Cry1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >13 publications with Cry1 and Cardiovascular Diseases
 Necrosis Antibodies  >11 publications with Cry1 and Necrosis
 Inflammation Antibodies  >10 publications with Cry1 and Inflammation
 Breast Neoplasms Antibodies  >9 publications with Cry1 and Breast Neoplasms
 Fatty Liver Antibodies  >6 publications with Cry1 and Fatty Liver
 Hypertension Antibodies  >6 publications with Cry1 and Hypertension
 Adenocarcinoma Antibodies  >5 publications with Cry1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >191 publications with Cry1 and Eye
 Brain Antibodies  >123 publications with Cry1 and Brain
 Liver Antibodies  >58 publications with Cry1 and Liver
 Kidney Antibodies  >11 publications with Cry1 and Kidney
 Embryonic Tissue Antibodies  >10 publications with Cry1 and Embryonic Tissue
 Lung Antibodies  >6 publications with Cry1 and Lung
 Bone Antibodies  >5 publications with Cry1 and Bone
 Skin Antibodies  >3 publications with Cry1 and Skin
 Testis Antibodies  >3 publications with Cry1 and Testis
 Ovary Antibodies  >2 publications with Cry1 and Ovary
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